CHF患者心功能相关指标与血清CA125、BNP、Hcy、FGF23水平的关系研究
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摘要
目的探讨慢性心功能衰竭(CHF)患者血清糖类抗原125(CA125)、B型钠尿肽(BNP)、同型半胱氨酸(Hcy)、成纤维细胞生长因子23(FGF23)水平变化与患者心功能指标的关系。方法选取我院确诊的CHF患者126例(CHF组),选取正常健康人群60例作为对照组,检测研究对象的血清CA125、BNP、Hcy、FGF23水平,采用超声心动图测量两组的左室射血分数(LVEF%)、左室舒张末期内径(LVEDd)、左心室质量指数(LVMI),并探讨血清指标与心功能指标的相关性。结果 CHF组的血清CA125、BNP、Hcy、FGF23水平显著的高于对照组(P <0. 05);Ⅰ级、Ⅱ级CHF组的血清CA125、BNP、Hcy、FGF23水平显著的低于Ⅲ级和ⅣCHF组患者(P<0.05);CHF组患者血清CA125、BNP、Hcy与LVEF%呈负相关关系(P<0.05),血清CA125、BNP、Hcy与LVEDd呈正相关关系(P<0.05),血清BNP、Hcy、FGF23与LVMI呈正相关关系(P<0.05)。结论 CHF组的血清CA125、BNP、Hcy、FGF23水平较正常人群显著的升高并且与超声心动图指标具有一定相关性。
Objective To investigate the changes of serum carbohydrate antigen 125(CA125),BNP(BNP),homocysteine(Hcy) and fibroblast growth factor 23(FGF23) in patients with chronic heart failure(CHF)and their relationships with cardiac function. Methods 126 cases of diagnosed CHF patients were enrolled in this study as the CHF group,while 60 healthy person were selected as the control group. The serum CA125,BNP,Hcy and FGF23 levels were measured among all patients. For both groups, left ventricular ejection fraction( LVEF%), left ventricular end diastolic diameter( LVEDd) and left ventricular mass index(LVMI) were measured by echocardiography. The correlations between serum indexes and cardiac function was evaluated. Results The levels of serum CA125, BNP, Hcy, and FGF23 in the CHF group were significantly higher than those in the control group( P <0. 05); the levels of serum CA125,BNP,Hcy,and FGF23 in the level I and II of the CHF groups were significantly lower than those in the level III and IV of the CHF groups. Among CHF patients,serum CA125,BNP,and Hcy were negatively correlated with LVEF%(P <0. 05), and positively correlated with LVEDd( P < 0. 05). Also, serum BNP and Hcy were positively correlated with LVMI(P < 0. 05) and serum FGF23 was positively correlated with LMVI( P < 0. 05).Conclusion The levels of serum CA125,BNP,Hcy and FGF23 in the CHF group are significantly higher than those in the control group,and are correlated with the echocardiographic parameters.
Objective To investigate the changes of serum carbohydrate antigen 125(CA125),BNP(BNP),homocysteine(Hcy) and fibroblast growth factor 23(FGF23) in patients with chronic heart failure(CHF)and their relationships with cardiac function. Methods 126 cases of diagnosed CHF patients were enrolled in this study as the CHF group,while 60 healthy person were selected as the control group. The serum CA125,BNP,Hcy and FGF23 levels were measured among all patients. For both groups, left ventricular ejection fraction( LVEF%), left ventricular end diastolic diameter( LVEDd) and left ventricular mass index(LVMI) were measured by echocardiography. The correlations between serum indexes and cardiac function was evaluated. Results The levels of serum CA125, BNP, Hcy, and FGF23 in the CHF group were significantly higher than those in the control group( P <0. 05); the levels of serum CA125,BNP,Hcy,and FGF23 in the level I and II of the CHF groups were significantly lower than those in the level III and IV of the CHF groups. Among CHF patients,serum CA125,BNP,and Hcy were negatively correlated with LVEF%(P <0. 05), and positively correlated with LVEDd( P < 0. 05). Also, serum BNP and Hcy were positively correlated with LVMI(P < 0. 05) and serum FGF23 was positively correlated with LMVI( P < 0. 05).Conclusion The levels of serum CA125,BNP,Hcy and FGF23 in the CHF group are significantly higher than those in the control group,and are correlated with the echocardiographic parameters.
引文
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[15] AYASHI K,SUZUKI T,SAKAMAKI Y,et al. Cardiac hypertrophy in chronic kidney disease-role of Aldosterone and FGF23[J]. Renal Replacement Therapy,2018,4(1):10.
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[3]易诗欣,黎励文.射血分数保留的心力衰竭是射血分数降低的心力衰竭的早期表现[J].中华心血管病杂志,2017,45(6):480-481.
[4]陆再英,钟南山.内科学[M].第7版,北京:人民卫生出版社,2008:213-214..
[5]王紫晨,魏占云,何婧瑜,等.老年慢性心力衰竭患者同型半胱费氨酸与N末端B型利钠肽原、左心室结构和功能的相关性[J].临床荟萃,2016,31(6):718-719.
[6]黄晓佳,梅敏,李成德,等.脑钠肽、同型半胱氨酸及肌钙蛋白I在慢性心力衰竭中的表达及临床意义[J].检验医学与临床,2016,13(13):1852-1854.
[7]罗莫孺.N端脑钠肽前体联合血清同型半胱氨酸检测对心力衰竭诊断价值评价[J].广东微量元素科学,2016,23(1):61-63.
[8]王淼,张强,王义围,等.老年患者射血分数保留心力衰竭与N端脑钠肽前体、超敏C反应蛋白、血尿酸及同型半胱氨酸的相关性[J].中国老年学杂志,2017,37(2):366-368.
[9]仇晓敏,胡晓晟,蒲建芬,等.冠心病心力衰竭患者QRS波时限与血浆Hey的相关性分析[J].中华全科医学,2016,14(7):194-195.
[10] VECCHIS R D, ARIANO C, BIASE G D, et al. Kognitive Leistungsf(a|¨)higkeit unter Sacubitril/Valsartan bei Patienten mit chronischer Herzinsuffizienz[J]. Herz,2018,5(3):1-7.
[11]李雪芹,朱文斌,姜凤霞.慢性心衰患者超声心功能指标与血清Hey的相关性[J].实用医学杂志,2017,33(4):579-582.
[12] CHUACC, HUTCHINSON A, TACEY M, et al. A physician targeted intervention improves prescribing in chronic heart failure in general medical units[J]. BMC Health Serv Res,2018,18(1):206.
[13] STOJKOVIC S, KOLLER L, SULZGRUBER P, et al. P298Liverspecific microRNA-122 as a prognostic biomarker in patients with chronic heart failure[J]. Cardiovascular Res, 2018, 114(suppl1):S76.
[14]彭友,莫炯灵,李华桦.老年慢性心衰患者血清同型半胱氨酸水平及其对心脏结构的影响[J].中国医药导报,2016,13(17):54-57.
[15] AYASHI K,SUZUKI T,SAKAMAKI Y,et al. Cardiac hypertrophy in chronic kidney disease-role of Aldosterone and FGF23[J]. Renal Replacement Therapy,2018,4(1):10.