冠心病患者冠脉血流储备分数与循环微粒的关系
摘要
目的研究冠状动脉粥样硬化性心脏病(冠心病)患者血流储备分数(FFR)与循环微粒(MPs)的关系。方法冠心病患者50例行冠脉造影术提示为中-重度狭窄为实验组;对照组为健康体检的志愿者30例的空腹静脉血;通过两步离心法提取两组MPs并检测其浓度,分析实验组FFR和MPs的关系,最后检测不同狭窄程度的冠心病患者MPs(相同浓度)对离体大鼠血管舒张功能及一氧化氮(NO)的影响。结果实验组体内MPs含量与FFR呈负相关;与对照组比较,实验组MPs抑制离体血管舒张功能和NO产生;实验组MPs抑制血管舒张功能和NO产生的能力与FFR呈负相关。结论冠心病患者体内MPs含量及对血管功能的影响能力与冠脉缺血程度呈正相关,MPs含量的高低可以一定程度上间接反映冠心病患者心肌缺血情况,进一步验证了MPs有作为内皮功能受损标志物的潜能。
引文
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2 Thanyasiri P,Kathir K,Celermajer DS,et al.Endothelial dysfunction and restenosis following percutaneous coronary intervention[J].Int J Cardiol,2007;119(3):362-7.
3 Izzo P,Macchi A,De Gennaro L,et al.Recurrent angina after coronary angioplasty:mechanisms,diagnostic and therapeutic options[J].Eur Heart J Acute Cardiovasc Care,2012;1(2):158-69.
4 Han WQ,Chang FJ,Wang QR,et al.Microparticles from patients with acute coronary syndrome impair vasodilatation by inhibiting the Akt/e NOS-Hsp90 signaling pathway[J].Cardiology,2015;132(4):252-60.
5 Nagy JA,Benjamin L,Zeng H,et al.Vascular permeability,vascular hyperpermeability and angiogenesis[J].Angiogenesis,2008;11(2):109-19.
6 Deanfield JE,Halcox JP,Rabelink TJ.Endothelial function and dysfunction:testing and clinical relevance[J].Circulation,2007;115(10):1285-95.
7 Marti CN,Gheorghiade M,Kalogeropoulos AP,et al.Endothelial dysfunction,arterial stiffness,and heart failure[J].J Am Coll Cardiol,2012;60(16):1455-69.
8 Moens AL,Claeys MJ,Timmermans JP,et al.Myocardial ischemia/reperfusion-injury,a clinical view on a complex pathophysiological process[J].Int J Cardiol,2005;100(2):179-90.
9 Diehl P,Nagy F,Sossong V,et al.Increased levels of circulating microparticles in patients with severe aortic valve stenosis[J].Thromb Haemost,2008;99(4):711-9.
10 Ahn YS,Jy W,Horstman LL,et al.Cell-derived microparticles:a mediator of inflammation in aortic valve stenosis[J]?Thromb Haemost,2008;99(4):657-8.