蒲葵子化学成分及药理活性的研究进展
|
摘要
目的综述蒲葵子化学成分及药理活性的研究进展,为进一步研究蒲葵子的抗癌机制提供依据,并为其临床应用提供参考。方法对近20年的相关文献进行系统调研,整理归纳与蒲葵子药理活性相关的文献。结果总结了蒲葵子的化学成分、药理活性、作用机制及毒性。结论蒲葵子中含有鞣质、酚类、黄酮、生物碱、甾体、糖及脂肪酸等多种化学成分。蒲葵子的药理活性主要体现为抗肿瘤活性,作为一味潜在的抗癌药,蒲葵子具有广阔的开发前景。
Objective To summarize the chemical constituents and pharmacological activities of Livistona chinensis,to provide basis for further anti-cancer mechanism researches and reasonable clinical applications of Livistona chinensis.Methods A systematic survey was conducted on the literatures which reported the pharmacological effects of Livistona chinensis and were published over the past 20 years.Results The constituents,pharmacological activities,mechanism and toxicities of Livistona chinensis were summarized.Conclusion Livistona chinensis is found containing various chemical components,including tannins,phenols,flavonoids,alkaloids,steroids,sugars,and fatty acids.So far,Livistona chinensis exhibits significant anti-cancer activity,thus it has the great value as a potential anticancer agent.
Objective To summarize the chemical constituents and pharmacological activities of Livistona chinensis,to provide basis for further anti-cancer mechanism researches and reasonable clinical applications of Livistona chinensis.Methods A systematic survey was conducted on the literatures which reported the pharmacological effects of Livistona chinensis and were published over the past 20 years.Results The constituents,pharmacological activities,mechanism and toxicities of Livistona chinensis were summarized.Conclusion Livistona chinensis is found containing various chemical components,including tannins,phenols,flavonoids,alkaloids,steroids,sugars,and fatty acids.So far,Livistona chinensis exhibits significant anti-cancer activity,thus it has the great value as a potential anticancer agent.
引文
[1] 广西壮族自治区卫生厅.广西中药材标准[M].南宁:广西壮族自治区卫生厅,1999:271-272.
[2] 江苏医学院.中药大辞典:下册[M].上海:上海科学出版社,2006:3430.
[3] 广州部队后勤部卫生部.常用中草药手册[M].北京:人民卫生出版社,1969:772-773.
[4] 陈艳.蒲葵子活性成分及质量控制研究[D].福州:福建医科大学,2011:1-157.
[5] 陈屏.小叶云实、蒲葵和黄三七的化学成分研究[D].北京:中国协和医科大学,2007:1-137.
[6] ZENG X B,WANG Y H,QIU Q,et al.Bioactive phenolics from the fruits of Livistona chinensis[J].Fitoterapia,2012,83(1):104-109.
[7] YUAN T,YANG S P,ZHANG H Y.Phenolic compounds with cell protective activity from the fruits of Livistona chinensis[J].Journal of Asian Natural Products Research,2009,11(3):243-249.
[8] HONG Y,YAN C,PEI Y S,et al.Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R.Br. using HPLC-DAD-ESI/MS coupled with pre-column DPPH assay[J].Food Chemistry,2012,135:2802-2807.
[9] 陈艳,姚宏,李少光,等.HPLC 法测定蒲葵药材中6种组分含量[J].药物分析杂志,2011,31(4):645-650.
[10] ZENG X B,QIU Q,JIANG C G,et al.Antioxidant flavanes from Livistona chinensis[J].Fitoterapia,2011,82(4):609-614.
[11] 柳雷,熊常健,朱岳麟.蒲葵籽活性单体的分离及其抗癌活性研究[J].北京化工大学学报,2015,42(6):78-82.
[12] 王慧,董小萍,李傲,等.蒲葵子脂肪酸组成分析[J].成都中医药大学学报,2008,31(2):43-44.
[13] WEN C H,YANN L L,JAU S Y.Cancer and Treatment with Seeds of Chinese Fan Palm (Livistona chinensis R.Brown.)[J].Nuts and Seeds in Health and Disease Preventiong,2011,39:325-331.
[14] MAR Y A S,CANHUILIU,ZHI M S,et al.Livistona extract inhibits angiogenesis and cancer growth[J].Oncology Reports,2001,8:1355-1357.
[15] 曾春晖,杨柯,郑作文.蒲葵子的含药血清体外抗肿瘤作用的实验研究[J].中药方剂,2007,30(1):58-59.
[16] 黄才,卓燕梅,梁念慈.石上柏和蒲葵子对蛋白激酶C活性的影响[J].中草药,1995,26(8):415-418.
[17] WEN C H,RAE M H,LANG M C,et al.Selective downregulation of EGF receptor and downstream MAPK pathway in human cancer cell lines by active components partially purified from the seeds of Livistona chinensis R.Brown.[J].Cancer Letters,2007,248:137-146.
[18] LIN W,ZHAO J,CAO Z,et al.Livistona chinensis seed suppresses hepatocellular carcinoma growth through promotion of mitochondrial-dependent apoptosis[J].Oncology Reports,2013,29:1859-1866.
[19] LIN W,ZHAO J,CAO Z,et al.Livistona chinensis seeds inhibit hepatocellular carcinoma angiogenesis in vivo via suppression of the Notch pathway[J].Oncology Reports,2014,31:1723-1728.
[20] ZHI Y C,LIANG P Z,JIN Y Z,et al.Antiangiogenic effect of Livistona chinensis seed extract in vitro and in vivo[J].Oncology Letters,2017,14:7565-7570.
[21] CORBIERE C,LIAGRE B,BIANCHIi A,et al.Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids,hecogenin and tigogenin,on human 1547 osteosarcoma cells[J].International Journal of Oncology,2003,22(4):899-906.
[22] CORBIERE C,LIAGRE B,TERRO F,et al.Induction of antiproliferative effect by diosgenin through activation of p53,release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells[J].Cell Research,2004,14(3):188-196.
[23] WANG W C,LIU S F,CHANG W T,et al.The effects of diosgenin in the regulation of renal proximal tubular fibrosis [J].Experimental Cell Research,2014,323(2):255-262.
[24] CHEN P S,SHIH Y W,HUANG H C,et al.Diosgenin,a steroidal saponin,inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression[J].PLos One,2011,6(5):e20164.
[25] HE Z,CHEN H,LI G,et al.Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity [J].Phytomedicine,2014,21(6):871-876.
[26] CHEN Y,TANG Y M,YU S L,et al.Advances in the pharmacological activities and mechanisms of diosgenin [J].Chinese Journal of Natural Medicines,2015,13(8):578-587.
[27] 刘志平,崔建国,黄初升,等.蒲葵籽中有效化学成分的研究[J].中草药,2007,38(2):178-180.
[28] EDUARDO P F L,QIN T W,WEI W,et al.Potential chemotherapeutic effects of diosgenin,zoledronic acid and epigallocatechin-3-gallate on PE/CA-PJ15 oral squamous cancer cell line[J].Archives of Oral Biology,2017,82:141-146.
[29] LEPAGE C,LEGER D Y,BERTRAND J,et al.Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells[J].Cancer Letters,2011,301:193-202.
[30] FENG L,PRASANA P F,PERAMAIYAN R,et al.Diosgenin,a steroidal saponin,inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells[J].Cancer Letters,2010,292:197-207.
[31] CHENG X S,ZHONG F,HE K,et al.EHHM,a novel phenolic natural product from Livistona chinensis,induces autophagy-related apoptosis in hepatocellular carcinoma cells[J].Oncology Letters,2016,12:3739-3748.
[32] 李春艳,曾艳波,彭芳,等.蒲葵籽提取物体外抗HIV-1活性及机制的初步研究[J].中草药,2008,39(12):1833-1838.
[33] GURPREET K,RAMAN P S.Antibacterial and membrane damaging activity of Livistona chinensis fruit extract[J].Food and Chemical Toxicology,2008,46:2429-2434.
[34] 钟振国,罗沛,黄燕.蒲葵子抗癌有效部位提取物的小鼠微核实验[J].时珍国医国药,2009,20(4):775-776.
[35] 黄燕,钟振国,罗沛.两种Ames试验方法在蒲葵子提取物致突变试验中灵敏度的研究[J].时珍国医国药,2009,20(7):1578-1579.
[36] SINGH R P,KAUR G.Hemolytic activity of aqueous extract of Livistona chinensis fruits[J].Food and Chemical Toxicology,2008,46:553-556.
[37] 丁庆,丁录,丁鉴.高效无毒纯天然抗癌剂[P].CN:97100103.0,1998-07-08.
[38] 吴英德,宋向群,胡晓桦,等.复方金蒲片临床研究概述[J].广西医学,2007,29(11):1722-1724.
[39] 涂文升,吴英德,刘颖新.复方金蒲片在肿瘤临床的应用观察[J].中国医院药学杂志,2010,30(11):938-941.
[40] 黄瑞松,叶云峰,苏青,等.复生康胶囊质量标准的研究[J].中草药,2003,34(8):698-701.
[2] 江苏医学院.中药大辞典:下册[M].上海:上海科学出版社,2006:3430.
[3] 广州部队后勤部卫生部.常用中草药手册[M].北京:人民卫生出版社,1969:772-773.
[4] 陈艳.蒲葵子活性成分及质量控制研究[D].福州:福建医科大学,2011:1-157.
[5] 陈屏.小叶云实、蒲葵和黄三七的化学成分研究[D].北京:中国协和医科大学,2007:1-137.
[6] ZENG X B,WANG Y H,QIU Q,et al.Bioactive phenolics from the fruits of Livistona chinensis[J].Fitoterapia,2012,83(1):104-109.
[7] YUAN T,YANG S P,ZHANG H Y.Phenolic compounds with cell protective activity from the fruits of Livistona chinensis[J].Journal of Asian Natural Products Research,2009,11(3):243-249.
[8] HONG Y,YAN C,PEI Y S,et al.Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R.Br. using HPLC-DAD-ESI/MS coupled with pre-column DPPH assay[J].Food Chemistry,2012,135:2802-2807.
[9] 陈艳,姚宏,李少光,等.HPLC 法测定蒲葵药材中6种组分含量[J].药物分析杂志,2011,31(4):645-650.
[10] ZENG X B,QIU Q,JIANG C G,et al.Antioxidant flavanes from Livistona chinensis[J].Fitoterapia,2011,82(4):609-614.
[11] 柳雷,熊常健,朱岳麟.蒲葵籽活性单体的分离及其抗癌活性研究[J].北京化工大学学报,2015,42(6):78-82.
[12] 王慧,董小萍,李傲,等.蒲葵子脂肪酸组成分析[J].成都中医药大学学报,2008,31(2):43-44.
[13] WEN C H,YANN L L,JAU S Y.Cancer and Treatment with Seeds of Chinese Fan Palm (Livistona chinensis R.Brown.)[J].Nuts and Seeds in Health and Disease Preventiong,2011,39:325-331.
[14] MAR Y A S,CANHUILIU,ZHI M S,et al.Livistona extract inhibits angiogenesis and cancer growth[J].Oncology Reports,2001,8:1355-1357.
[15] 曾春晖,杨柯,郑作文.蒲葵子的含药血清体外抗肿瘤作用的实验研究[J].中药方剂,2007,30(1):58-59.
[16] 黄才,卓燕梅,梁念慈.石上柏和蒲葵子对蛋白激酶C活性的影响[J].中草药,1995,26(8):415-418.
[17] WEN C H,RAE M H,LANG M C,et al.Selective downregulation of EGF receptor and downstream MAPK pathway in human cancer cell lines by active components partially purified from the seeds of Livistona chinensis R.Brown.[J].Cancer Letters,2007,248:137-146.
[18] LIN W,ZHAO J,CAO Z,et al.Livistona chinensis seed suppresses hepatocellular carcinoma growth through promotion of mitochondrial-dependent apoptosis[J].Oncology Reports,2013,29:1859-1866.
[19] LIN W,ZHAO J,CAO Z,et al.Livistona chinensis seeds inhibit hepatocellular carcinoma angiogenesis in vivo via suppression of the Notch pathway[J].Oncology Reports,2014,31:1723-1728.
[20] ZHI Y C,LIANG P Z,JIN Y Z,et al.Antiangiogenic effect of Livistona chinensis seed extract in vitro and in vivo[J].Oncology Letters,2017,14:7565-7570.
[21] CORBIERE C,LIAGRE B,BIANCHIi A,et al.Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids,hecogenin and tigogenin,on human 1547 osteosarcoma cells[J].International Journal of Oncology,2003,22(4):899-906.
[22] CORBIERE C,LIAGRE B,TERRO F,et al.Induction of antiproliferative effect by diosgenin through activation of p53,release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells[J].Cell Research,2004,14(3):188-196.
[23] WANG W C,LIU S F,CHANG W T,et al.The effects of diosgenin in the regulation of renal proximal tubular fibrosis [J].Experimental Cell Research,2014,323(2):255-262.
[24] CHEN P S,SHIH Y W,HUANG H C,et al.Diosgenin,a steroidal saponin,inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression[J].PLos One,2011,6(5):e20164.
[25] HE Z,CHEN H,LI G,et al.Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity [J].Phytomedicine,2014,21(6):871-876.
[26] CHEN Y,TANG Y M,YU S L,et al.Advances in the pharmacological activities and mechanisms of diosgenin [J].Chinese Journal of Natural Medicines,2015,13(8):578-587.
[27] 刘志平,崔建国,黄初升,等.蒲葵籽中有效化学成分的研究[J].中草药,2007,38(2):178-180.
[28] EDUARDO P F L,QIN T W,WEI W,et al.Potential chemotherapeutic effects of diosgenin,zoledronic acid and epigallocatechin-3-gallate on PE/CA-PJ15 oral squamous cancer cell line[J].Archives of Oral Biology,2017,82:141-146.
[29] LEPAGE C,LEGER D Y,BERTRAND J,et al.Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells[J].Cancer Letters,2011,301:193-202.
[30] FENG L,PRASANA P F,PERAMAIYAN R,et al.Diosgenin,a steroidal saponin,inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells[J].Cancer Letters,2010,292:197-207.
[31] CHENG X S,ZHONG F,HE K,et al.EHHM,a novel phenolic natural product from Livistona chinensis,induces autophagy-related apoptosis in hepatocellular carcinoma cells[J].Oncology Letters,2016,12:3739-3748.
[32] 李春艳,曾艳波,彭芳,等.蒲葵籽提取物体外抗HIV-1活性及机制的初步研究[J].中草药,2008,39(12):1833-1838.
[33] GURPREET K,RAMAN P S.Antibacterial and membrane damaging activity of Livistona chinensis fruit extract[J].Food and Chemical Toxicology,2008,46:2429-2434.
[34] 钟振国,罗沛,黄燕.蒲葵子抗癌有效部位提取物的小鼠微核实验[J].时珍国医国药,2009,20(4):775-776.
[35] 黄燕,钟振国,罗沛.两种Ames试验方法在蒲葵子提取物致突变试验中灵敏度的研究[J].时珍国医国药,2009,20(7):1578-1579.
[36] SINGH R P,KAUR G.Hemolytic activity of aqueous extract of Livistona chinensis fruits[J].Food and Chemical Toxicology,2008,46:553-556.
[37] 丁庆,丁录,丁鉴.高效无毒纯天然抗癌剂[P].CN:97100103.0,1998-07-08.
[38] 吴英德,宋向群,胡晓桦,等.复方金蒲片临床研究概述[J].广西医学,2007,29(11):1722-1724.
[39] 涂文升,吴英德,刘颖新.复方金蒲片在肿瘤临床的应用观察[J].中国医院药学杂志,2010,30(11):938-941.
[40] 黄瑞松,叶云峰,苏青,等.复生康胶囊质量标准的研究[J].中草药,2003,34(8):698-701.