丹参多酚酸盐注射液联合酒石酸美托洛尔治疗不稳定型心绞痛的临床效果
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摘要
目的研究丹参多酚酸盐注射液联合酒石酸美托洛尔对不稳定型心绞痛(UAP)患者心电图及血清妊娠相关血浆蛋白A(PAPP-A)、可溶性白细胞分化抗原配体(sCD40L)水平的影响。方法将96例UAP患者按随机数字表法分为研究组(n=48)和对照组(n=48),对照组采用酒石酸美托洛尔治疗,研究组采用丹参多酚酸盐注射液联合酒石酸美托洛尔治疗。比较2组心电图疗效、临床症状(包括发作次数、疼痛程度、持续时间、硝酸甘油用量)评分改善情况及治疗前后血清PAPP-A、sCD40L水平变化情况。结果研究组心电图总有效率显著高于对照组(93.75%比75.00%,χ~2=6.400、P=0.011);研究组治疗后发作次数、疼痛程度、持续时间、硝酸甘油用量等评分均较对照组显著改善(P<0.05);治疗后2组血清PAPP-A、sCD40L水平均显著低于治疗前(P<0.05),且研究组显著低于对照组(P<0.05)。结论丹参多酚酸盐注射液联合酒石酸美托洛尔治疗UAP患者,能显著提高心电图疗效,进一步改善心绞痛症状,降低血清PAPP-A、sCD40L水平,有利于改善预后。
Objective To study the effect of salvianolate injection combined with metoprolol tartrate on electrocardiogram and serum pregnancy-associated plasma protein A(PAPP-A) and soluble leukocyte differentiation antigen ligand(sCD40 L) levels in patients with unstable angina pectoris(UAP).Methods Ninety-six patients with UAP were randomly treated with metoprolol tartrate alone(control group,n=48) or in combination with salvianolate injection(study group,n=48).The electrocardiogram and scores of clinical symptoms(episode number,pain degree,duration,nitroglycerin dosage) were compared between the two groups.In addition,serum PAPP-A and sCD40 L levels were measured before and after treatment.Results The total effective rate of electrocardiogram in study group was higher than that in control group(93.75% vs 75.00%,χ~2=6.400,P=0.011).Furthermore,compared with control group,the scores of episode number,pain degree,duration and nitroglycerin dosage were improved in study group(P<0.05).Moreover,serum PAPP-A and sCD40 L levels after treatment were lower than those before treatment in both groups,and those in study group were lower than those in control group(P<0.05).ConclusionSalvianolate injection combined with metoprolol tartrate can improve electrocardiogram results,relieve angina pectoris symptoms,reduce serum PAPP-A and sCD40 L levels and ameliorate the prognosis in patients with UAP.
Objective To study the effect of salvianolate injection combined with metoprolol tartrate on electrocardiogram and serum pregnancy-associated plasma protein A(PAPP-A) and soluble leukocyte differentiation antigen ligand(sCD40 L) levels in patients with unstable angina pectoris(UAP).Methods Ninety-six patients with UAP were randomly treated with metoprolol tartrate alone(control group,n=48) or in combination with salvianolate injection(study group,n=48).The electrocardiogram and scores of clinical symptoms(episode number,pain degree,duration,nitroglycerin dosage) were compared between the two groups.In addition,serum PAPP-A and sCD40 L levels were measured before and after treatment.Results The total effective rate of electrocardiogram in study group was higher than that in control group(93.75% vs 75.00%,χ~2=6.400,P=0.011).Furthermore,compared with control group,the scores of episode number,pain degree,duration and nitroglycerin dosage were improved in study group(P<0.05).Moreover,serum PAPP-A and sCD40 L levels after treatment were lower than those before treatment in both groups,and those in study group were lower than those in control group(P<0.05).ConclusionSalvianolate injection combined with metoprolol tartrate can improve electrocardiogram results,relieve angina pectoris symptoms,reduce serum PAPP-A and sCD40 L levels and ameliorate the prognosis in patients with UAP.
引文
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[7] 陈世莲,黄胜兵.丹参多酚酸盐对不稳定型心绞痛患者相关细胞因子的影响[J].海南医学院学报,2016,26(8):744-746.
[2] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:68-73.
[3] 王子良,刘伟霞,范骞,等.酒石酸美托洛尔治疗不稳定型心绞痛的临床疗效[J].中国实用医药,2016,11(24):137-138.
[4] 任小龙.丹参注射液联合酒石酸美托洛尔对不稳定型心绞痛患者的影响[J].实用心脑肺血管病杂志,2017,25(10):142-144.
[5] 王妮,毕云.丹参多酚酸盐对不稳定型心绞痛患者相关细胞因子的影响[J].现代中西医结合杂志,2017,26(2):184-186.
[6] 陈霞.前列地尔联合丹参多酚酸盐治疗不稳定型心绞痛的疗效及对内皮功能的影响[J].浙江临床医学,2016,18(7):1229-1230.
[7] 陈世莲,黄胜兵.丹参多酚酸盐对不稳定型心绞痛患者相关细胞因子的影响[J].海南医学院学报,2016,26(8):744-746.