副猪嗜血杆菌转铁结合蛋白研究进展
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摘要
副猪嗜血杆菌是猪革拉泽氏病的病原体,该病是近年来严重危害养猪业的细菌性传染病之一,呈世界性分布。副猪嗜血杆菌相关致病性毒力因子的研究目前很少,关于转铁结合蛋白更是鲜为人知。在此对副猪嗜血杆菌转铁结合蛋白的结构、形成机制、影响因素及其免疫原性进行综述,对阐明致病菌的慢性感染机理有一定的生物学意义。
Haemophilus parasuis is the etiological agent of Glasser's disease in pigs,which is responsible for considerable economic losses in the pig industry.The disease is distributed worldwide.Few studies of the virulence factors involved in the pathogenicity of H.parasuis have been reported to date,especially transferrin-binding proteins.Summarizing structure,mechanisms for iron acquisition,impact factor and relevant studies in recent years is important for understanding the chronic infection and antibiotic resistance.
Haemophilus parasuis is the etiological agent of Glasser's disease in pigs,which is responsible for considerable economic losses in the pig industry.The disease is distributed worldwide.Few studies of the virulence factors involved in the pathogenicity of H.parasuis have been reported to date,especially transferrin-binding proteins.Summarizing structure,mechanisms for iron acquisition,impact factor and relevant studies in recent years is important for understanding the chronic infection and antibiotic resistance.
引文
[1]Smart N L,Miniats O P.Preliminary assessment of a Haemophi-lus parasuis bacterin for use in specific pathogen free swine[J].VetRes,1989,53,390-393.
[2]冯小明,储岳峰,贺英,等.副猪嗜血杆菌毒力因子研究进展[J].生物技术通报,2010,(12):46-49
[3]Olvera A,Ballester M,Nof rarías M,et al.Differences in phago-cytosis susceptibility in Haemophilus parasuis strains[J].Vet Res,2009,40(3):24.
[4]陈金山,李任峰,马金友,等.副猪嗜血杆菌病的诊断和治疗[J].动物医学进展,2011,32(2):117-119.
[5]张晓燕,明心中,何后军.副猪嗜血杆菌病原学研究进展[J].江西畜牧兽医杂志,2009,(2):8-10.
[6]余小利,苏丹萍,贺东生.副猪嗜血杆菌的分型技术研究进展[J].广东畜牧兽医科技,2010,35(4):13-16
[7]Ruiz A,Oliveira S,Torremorell M,et al.Outer membrane pro-teins and DNA profiles in strains of Haemophilus parasuis recov-ered from systemic and respiratory sites[J].Clin Microbiol,2001,39:757-1762.
[8]Litwin C M,Calderwood S B.Role of iron inregulation of virulencegenes[J].Clin Microbiol Rev,1993,6:137-149.
[9]del Río M L,Gutierrez-Martin C B,Rodriguez-Barbosa J I,et al.Identification and characterization of the TonB region and its role intransferrin-mediated iron acquisition in Haemophilus parasuis[J].FEMS Immunol Med Microbiol,2005,45(1):75-86.
[10]李任峰,田香勤,等.猪胸膜放线杆菌转铁结合蛋白基因(Tb-pB)分析及建模[J].生物信息学,2010,8(1):47-51
[11]Morton D J,Williams P.Utilization of transferrinbound ironby Haemophilus species of human and porcine origins[J].FEMS Microbiol Lett,1989,53:123-127.
[12]Charland N D,Silva C G,Dumont R A,et al.Contact-de-pendent acquisition of transferrin-bound iron by two strains ofHaemophilus parasuis[J].Can J Microbiol,1995,41:70-74.
[13]Bahrami F,Ekins A,Niven D F.Iron acquisition by Acti-nobacillus suis:Identification and characterization of transfer-rin receptor proteins and encoding genes[J].Vet Microbiol,2003,94:79-92.
[14]Occhino D A,Wyckoff E E,Henderson D P,et al.Vibriocholerae iron transport:Haem transport genes are linked toone of two sets of tonB,exbB,exbD genes[J].Mol Microbi-ol,1998,29:1493-1507.
[15]Bosch M,Garrido E,Llagostera M,et al.Pasteurella mul-tocida exbB,exbD and tonB genes are physically linked butindependently transcribed[J].FEMS Microbiol Lett,2002,210:201-208.
[16]Litwin C M,Calderwond S B.Role of iron in regulation ofvirulence genes[J].Clin Microbiol Rev,1993,6(2):137-149.
[17]de la Puente Redondo V A,García del Blanco N,GutiérrezMartín C B,et al.Detection and subtyping of Actinobacilluspleuropneumoniae strains by PCR-RFLP analysis of the tbpAand tbpB genes[J].Res Microbiol,2000,151:669-681.
[18]Zhang B,Feng S,Xu C,et al.Serum resistance inHaemophilus parasuis SC096strain requires outer membraneprotein P2expression[J].FEMS Microbiol Lett,2012,326(2):109-115.
[19]贺云霞,徐慧,叶飞,等.副猪嗜血杆菌EZ-Tn5转座子插入突变体库的构建及减毒株的筛选[J].安徽农业科学,2011,39(13):7820-7823.
[20]马艳萍.副猪嗜血杆菌生物被膜形成相关基因luxS和pilA的克隆和功能鉴定[D].北京:中国农业科学院,2010
[21]张念章.副猪嗜血杆菌hhdA基因缺失株的构建及胞外丝氨酸蛋白酶免疫原性的研究[D].北京:中国农业科学院,2011
[22]Martindela Fuente A J,Gutierrez Martin C B,Perez Martin-ez C,et al.Effect of different vaccine formulations on the de-velopment of Glasser’s disease induced in pigs by experimen-tal Haemophilus parasuis infection[J].Comp Pathol,2009,140:169-176.
[23]Zhou M,Guo Y,Zhao J,et al.Identification and character-ization of novel immunogenic outer membrane proteins ofHaemophilus parasuis serovar 5[J].Vaccine 2009,27:5271-5277.
[24]Zhang B,Tang C,Yang F L,et al.Molecular cloning,se-quencing and expression of the outer membrane protein Agene fromHaemophilus parasuis[J].Vet Microbiol,2009,136(3-4):408-410.
[25]Rokbi B,Mignon M,Maitre-Wilmotte G,et al.Evaluationof recombinant transferrin-binding protein B variants fromNeisseria meningitidis for their ability to induce cross-reac-tive and bactericidal antibodies against a genetically diversecollection of serogroup B strains.Infect[J].Immun,1997,65:55-63.
[26]Metcalf D S,MacInnes J I.Differential expression ofHaemophilus parasuis genes in response to iron restrictionand cerebrospinal fluid[J].Can J Vet Res,2007,71(3):181-188.
[27]Li J L,Jiang P,Wang Y,et al Genotyping of Haemophilusparasuis from diseased pigs in China and prevalence of twocoexisting virus pathogens[J].Prev Vet Med,2009,91:274-279.
[28]Martinez S,Frandoloso R,Rodriguez-Ferri E F,et al.Char-acterization of a recombinant transferrin-binding protein A(TbpA)fragment from Haemophilus parasuis serovar 5[J].FEMS Microbiol Lett,2010,307(2):142-150.
[2]冯小明,储岳峰,贺英,等.副猪嗜血杆菌毒力因子研究进展[J].生物技术通报,2010,(12):46-49
[3]Olvera A,Ballester M,Nof rarías M,et al.Differences in phago-cytosis susceptibility in Haemophilus parasuis strains[J].Vet Res,2009,40(3):24.
[4]陈金山,李任峰,马金友,等.副猪嗜血杆菌病的诊断和治疗[J].动物医学进展,2011,32(2):117-119.
[5]张晓燕,明心中,何后军.副猪嗜血杆菌病原学研究进展[J].江西畜牧兽医杂志,2009,(2):8-10.
[6]余小利,苏丹萍,贺东生.副猪嗜血杆菌的分型技术研究进展[J].广东畜牧兽医科技,2010,35(4):13-16
[7]Ruiz A,Oliveira S,Torremorell M,et al.Outer membrane pro-teins and DNA profiles in strains of Haemophilus parasuis recov-ered from systemic and respiratory sites[J].Clin Microbiol,2001,39:757-1762.
[8]Litwin C M,Calderwood S B.Role of iron inregulation of virulencegenes[J].Clin Microbiol Rev,1993,6:137-149.
[9]del Río M L,Gutierrez-Martin C B,Rodriguez-Barbosa J I,et al.Identification and characterization of the TonB region and its role intransferrin-mediated iron acquisition in Haemophilus parasuis[J].FEMS Immunol Med Microbiol,2005,45(1):75-86.
[10]李任峰,田香勤,等.猪胸膜放线杆菌转铁结合蛋白基因(Tb-pB)分析及建模[J].生物信息学,2010,8(1):47-51
[11]Morton D J,Williams P.Utilization of transferrinbound ironby Haemophilus species of human and porcine origins[J].FEMS Microbiol Lett,1989,53:123-127.
[12]Charland N D,Silva C G,Dumont R A,et al.Contact-de-pendent acquisition of transferrin-bound iron by two strains ofHaemophilus parasuis[J].Can J Microbiol,1995,41:70-74.
[13]Bahrami F,Ekins A,Niven D F.Iron acquisition by Acti-nobacillus suis:Identification and characterization of transfer-rin receptor proteins and encoding genes[J].Vet Microbiol,2003,94:79-92.
[14]Occhino D A,Wyckoff E E,Henderson D P,et al.Vibriocholerae iron transport:Haem transport genes are linked toone of two sets of tonB,exbB,exbD genes[J].Mol Microbi-ol,1998,29:1493-1507.
[15]Bosch M,Garrido E,Llagostera M,et al.Pasteurella mul-tocida exbB,exbD and tonB genes are physically linked butindependently transcribed[J].FEMS Microbiol Lett,2002,210:201-208.
[16]Litwin C M,Calderwond S B.Role of iron in regulation ofvirulence genes[J].Clin Microbiol Rev,1993,6(2):137-149.
[17]de la Puente Redondo V A,García del Blanco N,GutiérrezMartín C B,et al.Detection and subtyping of Actinobacilluspleuropneumoniae strains by PCR-RFLP analysis of the tbpAand tbpB genes[J].Res Microbiol,2000,151:669-681.
[18]Zhang B,Feng S,Xu C,et al.Serum resistance inHaemophilus parasuis SC096strain requires outer membraneprotein P2expression[J].FEMS Microbiol Lett,2012,326(2):109-115.
[19]贺云霞,徐慧,叶飞,等.副猪嗜血杆菌EZ-Tn5转座子插入突变体库的构建及减毒株的筛选[J].安徽农业科学,2011,39(13):7820-7823.
[20]马艳萍.副猪嗜血杆菌生物被膜形成相关基因luxS和pilA的克隆和功能鉴定[D].北京:中国农业科学院,2010
[21]张念章.副猪嗜血杆菌hhdA基因缺失株的构建及胞外丝氨酸蛋白酶免疫原性的研究[D].北京:中国农业科学院,2011
[22]Martindela Fuente A J,Gutierrez Martin C B,Perez Martin-ez C,et al.Effect of different vaccine formulations on the de-velopment of Glasser’s disease induced in pigs by experimen-tal Haemophilus parasuis infection[J].Comp Pathol,2009,140:169-176.
[23]Zhou M,Guo Y,Zhao J,et al.Identification and character-ization of novel immunogenic outer membrane proteins ofHaemophilus parasuis serovar 5[J].Vaccine 2009,27:5271-5277.
[24]Zhang B,Tang C,Yang F L,et al.Molecular cloning,se-quencing and expression of the outer membrane protein Agene fromHaemophilus parasuis[J].Vet Microbiol,2009,136(3-4):408-410.
[25]Rokbi B,Mignon M,Maitre-Wilmotte G,et al.Evaluationof recombinant transferrin-binding protein B variants fromNeisseria meningitidis for their ability to induce cross-reac-tive and bactericidal antibodies against a genetically diversecollection of serogroup B strains.Infect[J].Immun,1997,65:55-63.
[26]Metcalf D S,MacInnes J I.Differential expression ofHaemophilus parasuis genes in response to iron restrictionand cerebrospinal fluid[J].Can J Vet Res,2007,71(3):181-188.
[27]Li J L,Jiang P,Wang Y,et al Genotyping of Haemophilusparasuis from diseased pigs in China and prevalence of twocoexisting virus pathogens[J].Prev Vet Med,2009,91:274-279.
[28]Martinez S,Frandoloso R,Rodriguez-Ferri E F,et al.Char-acterization of a recombinant transferrin-binding protein A(TbpA)fragment from Haemophilus parasuis serovar 5[J].FEMS Microbiol Lett,2010,307(2):142-150.