赣南地区过敏性皮肤病变应原谱分析
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摘要
目的研究赣南地区过敏性皮肤病变应原谱,明确赣南地区过敏性皮肤病常见变应原,为赣南地区过敏性皮肤病的防治提供依据。方法临床纳入赣南地区2015年10月~2017年10月的1126例过敏性皮肤病患者作为研究对象。根据患者不同年龄段分为儿童组(≤14岁)316例,青少年组(>14~34岁)529例,中老年组(>34岁)281例。采用免疫印迹法对所有患者血清进行特异性IgE检测,测定变应原,分析不同年龄段患者的变应原阳性率情况。结果吸入性变应原中以户尘螨/粉尘螨和矮豚草/蒿最为常见,阳性率明显高于其他种类(P<0.05);食入性变应原中以鱼/虾/蟹和腰果/花生/黄豆最为常见,阳性率明显高于其他种类(P<0.05)。儿童组、青少年组及老年组单种阳性率高于2种及以上阳性率(P<0.05)。变应原方式方面,不同年龄组内吸入性和食入性阳性率比较,差异无统计学意义(P>0.05)。中老年组变应原种类方面,单种阳性率和2种及以上阳性率明显低于儿童组和青少年组(P<0.05);变应原方式方面,吸入性、食入性阳性率均低于儿童组和青少年组(P<0.05)。结论导致赣南地区过敏性皮肤病的吸入性变应原以户尘螨/粉尘螨和矮豚草/蒿为主,食入性变应原以鱼/虾/蟹和腰果/花生/黄豆为主,年龄越小越容易发生过敏性皮肤病,因此应扩大赣南地区海鲜、坚果类变应原种类的检测,对年龄较小的儿童进行积极预防,可进一步降低赣南地区过敏性皮肤病的发生率。
Objective To study the allergen spectrum of allergic skin diseases in Southern Jiangxi Province and to identify the common allergens of allergic skin diseases in this area,and to provide evidence for the prevention and treatment of allergic skin diseases in Southern Jiangxi Province.Methods A total of 1126 cases of allergic dermatosis in Southern Jiangxi Province from October 2015 to October 2017 were enrolled in this study.According to different age groups,they were divided into the children group(≤14 years old,n=316),the adolescent group(>14-34 years old,n=529) and the middle-aged and elderly group(>34 years old,n=281).Western blotting was used to detect the specific IgE from serum in all the patients to identify the allergens and analyze the positivity rate of allergen different age groups.Results The home dust mite/dermatophagoides farina and dwarf ragweed/artemisia were common in the inhaled allergens,and the positivity rate was higher than that other species(P<0.05).In food intake group,allergens such as fish,shrimp,crab and cashew nuts,peanut,and soybean were the most common with a higher positivity rate than that other species(P<0.05).The positivity rates of single species in the children group,the adolescent group and the middle-aged and elderly group were all higher than those of two and above species(P<0.05).There was no difference in the positivity rates of inhalation and ingestion of allergens between different age groups(P>0.05).In the middle-aged and elderly group,the positivity rates of single species and two species and more were significantly lower than those in the children and the adolescent groups(P<0.05).The positivity rates of allergen inhalation and ingestion were both lower than those in the children and adolescent groups(P<0.05).Conclusion Inhaled allergens that caused allergic skin diseases in Southern Jiangxi Province mainly are home dust mite/dermatophagoides farina and dwarf ragweed/artemisia,and for in-feed allergens,fish,shrimp,crab and cashew nuts,peanut,and soybean take the priority.The younger the patient is,the more prone the allergic skin disease occurs,therefore,expansion to detect the allergen species such as seafood and nuts in Southern Jiangxi Province and active prevention on younger children can further reduce the incidence of allergic skin diseases in this area.
Objective To study the allergen spectrum of allergic skin diseases in Southern Jiangxi Province and to identify the common allergens of allergic skin diseases in this area,and to provide evidence for the prevention and treatment of allergic skin diseases in Southern Jiangxi Province.Methods A total of 1126 cases of allergic dermatosis in Southern Jiangxi Province from October 2015 to October 2017 were enrolled in this study.According to different age groups,they were divided into the children group(≤14 years old,n=316),the adolescent group(>14-34 years old,n=529) and the middle-aged and elderly group(>34 years old,n=281).Western blotting was used to detect the specific IgE from serum in all the patients to identify the allergens and analyze the positivity rate of allergen different age groups.Results The home dust mite/dermatophagoides farina and dwarf ragweed/artemisia were common in the inhaled allergens,and the positivity rate was higher than that other species(P<0.05).In food intake group,allergens such as fish,shrimp,crab and cashew nuts,peanut,and soybean were the most common with a higher positivity rate than that other species(P<0.05).The positivity rates of single species in the children group,the adolescent group and the middle-aged and elderly group were all higher than those of two and above species(P<0.05).There was no difference in the positivity rates of inhalation and ingestion of allergens between different age groups(P>0.05).In the middle-aged and elderly group,the positivity rates of single species and two species and more were significantly lower than those in the children and the adolescent groups(P<0.05).The positivity rates of allergen inhalation and ingestion were both lower than those in the children and adolescent groups(P<0.05).Conclusion Inhaled allergens that caused allergic skin diseases in Southern Jiangxi Province mainly are home dust mite/dermatophagoides farina and dwarf ragweed/artemisia,and for in-feed allergens,fish,shrimp,crab and cashew nuts,peanut,and soybean take the priority.The younger the patient is,the more prone the allergic skin disease occurs,therefore,expansion to detect the allergen species such as seafood and nuts in Southern Jiangxi Province and active prevention on younger children can further reduce the incidence of allergic skin diseases in this area.
引文
[1]马晓蕾,孙青苗,贾军,等.过敏性皮肤病患者血清食入性和吸入性过敏原特异性Ig E结果分析[J].北京大学学报(医学版),2012,44(5):765-769.
[2]Barnes N,Pavord I,Chuchalin A,et al.A randomized,doubleblind,placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma[J].Clin Exp Allergy,2012,42(1):38-48.
[3]廉翠红,张书岭,刘恩让,等.1017例过敏性皮肤病患者特异性Ig E检测结果分析[J].中华实用诊断与治疗杂志,2012,26(12):1242-1244.
[4]张蕊娜,许颖,段晓涵,等.过敏性皮肤病1774例过敏原检测结果分析[J].中国皮肤性病学杂志,2012,26(4):317-318,329.
[5]何平,蒋远文,费世杰,等.百色市儿童常见过敏性皮肤病变应原检测与分析[J].右江医学,2016,44(5):530-535.
[6]李丽娟,陈明,潘红梅,等.宁波地区542例儿童过敏性皮肤病的血清过敏原研究[J].现代实用医学,2016,28(7):929-930,935.
[7]周晓毅,吴丽惠.611例过敏性疾病患者皮肤变应原点刺试验结果分析[J].中国麻风皮肤病杂志,2014,30(2):82.
[8]周晓毅,吴丽惠,李志民,等.泉州地区1182例过敏性疾病患者过敏原检测结果分析[J].皮肤病与性病,2014,36(6):334-336.
[9]张兰娟,刘娅,程玉娟,等.皮炎湿疹类皮肤病斑贴试验285例分析[J].北京医学,2015,37(3):294-295.
[10]李柯旻,高洁,李晓红,等.过敏性皮肤病282例患者血清总Ig E及特异性Ig E检测分析[J].中国临床研究,2013,26(1):52-53.
[11]龙玲珑,姚煦,杨雪源,等.变应原特异性免疫治疗特应性皮炎的进展[J].国际皮肤性病学杂志,2017,43(2):65-68.
[12]李慧,冯海瑕,俞先水,等.2036例过敏相关疾病体外过敏原特异性Ig E检测与分析[J].国际皮肤性病学杂志,2014,40(4):212-214.
[13]戚喜萍.过敏性皮肤病患者血清食入性和吸入性过敏原特异性Ig E结果分析[J].中国现代医生,2016,54(14):94-96.
[14]曲蓓蕾,行超然.湿疹患儿血清过敏原Ig E检查研究[J].中国医药科学,2016,6(21):192-194.
[15]陈丰.血清总免疫球蛋白E和特异性免疫球蛋白E联合检测在小儿喘息性疾病诊断中的应用价值[J].中国当代医药,2015,22(20):68-70.
[16]朱丁峰,马宏裕,尤小燕,等.1730例皮肤过敏患者常见吸入性变应原及脱敏治疗效果[J].江苏医药,2013,39(24):3069-3070.
[17]于青青,王跃建,唐隽,等.佛山市禅城区小学生变应性疾病的流行病学调查分析[J].中国医药科学,2016,6(13):40-44.
[18]徐炽友,胥华,孙琦巍,等.变态反应性皮肤病患者2076例变应原检测结果分析[J].临床医学,2013,33(1):1-4.
[19]杨晓静,冯冬梅,朱由瑾,等.变态反应性皮肤病患者过敏原特异性Ig E与总Ig E水平分析[J].解放军预防医学杂志,2017,35(5):451-453.
[2]Barnes N,Pavord I,Chuchalin A,et al.A randomized,doubleblind,placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma[J].Clin Exp Allergy,2012,42(1):38-48.
[3]廉翠红,张书岭,刘恩让,等.1017例过敏性皮肤病患者特异性Ig E检测结果分析[J].中华实用诊断与治疗杂志,2012,26(12):1242-1244.
[4]张蕊娜,许颖,段晓涵,等.过敏性皮肤病1774例过敏原检测结果分析[J].中国皮肤性病学杂志,2012,26(4):317-318,329.
[5]何平,蒋远文,费世杰,等.百色市儿童常见过敏性皮肤病变应原检测与分析[J].右江医学,2016,44(5):530-535.
[6]李丽娟,陈明,潘红梅,等.宁波地区542例儿童过敏性皮肤病的血清过敏原研究[J].现代实用医学,2016,28(7):929-930,935.
[7]周晓毅,吴丽惠.611例过敏性疾病患者皮肤变应原点刺试验结果分析[J].中国麻风皮肤病杂志,2014,30(2):82.
[8]周晓毅,吴丽惠,李志民,等.泉州地区1182例过敏性疾病患者过敏原检测结果分析[J].皮肤病与性病,2014,36(6):334-336.
[9]张兰娟,刘娅,程玉娟,等.皮炎湿疹类皮肤病斑贴试验285例分析[J].北京医学,2015,37(3):294-295.
[10]李柯旻,高洁,李晓红,等.过敏性皮肤病282例患者血清总Ig E及特异性Ig E检测分析[J].中国临床研究,2013,26(1):52-53.
[11]龙玲珑,姚煦,杨雪源,等.变应原特异性免疫治疗特应性皮炎的进展[J].国际皮肤性病学杂志,2017,43(2):65-68.
[12]李慧,冯海瑕,俞先水,等.2036例过敏相关疾病体外过敏原特异性Ig E检测与分析[J].国际皮肤性病学杂志,2014,40(4):212-214.
[13]戚喜萍.过敏性皮肤病患者血清食入性和吸入性过敏原特异性Ig E结果分析[J].中国现代医生,2016,54(14):94-96.
[14]曲蓓蕾,行超然.湿疹患儿血清过敏原Ig E检查研究[J].中国医药科学,2016,6(21):192-194.
[15]陈丰.血清总免疫球蛋白E和特异性免疫球蛋白E联合检测在小儿喘息性疾病诊断中的应用价值[J].中国当代医药,2015,22(20):68-70.
[16]朱丁峰,马宏裕,尤小燕,等.1730例皮肤过敏患者常见吸入性变应原及脱敏治疗效果[J].江苏医药,2013,39(24):3069-3070.
[17]于青青,王跃建,唐隽,等.佛山市禅城区小学生变应性疾病的流行病学调查分析[J].中国医药科学,2016,6(13):40-44.
[18]徐炽友,胥华,孙琦巍,等.变态反应性皮肤病患者2076例变应原检测结果分析[J].临床医学,2013,33(1):1-4.
[19]杨晓静,冯冬梅,朱由瑾,等.变态反应性皮肤病患者过敏原特异性Ig E与总Ig E水平分析[J].解放军预防医学杂志,2017,35(5):451-453.