观察补肾活血颗粒治疗90例妇女绝经后骨质疏松症的临床效果
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摘要
目的 :观察补肾活血颗粒治疗妇女绝经后骨质疏松症的临床效果。方法 :选取2015年12月～2017年09月在我院进行治疗的180例妇女绝经后骨质疏松症患者,根据数字表法随机分为对照组和观察组,每组90例患者。对照组患者给予骨营养剂治疗,观察组患者采用补肾活血颗粒治疗。对比两组患者治疗前后血清甲状旁腺素(PTH)、尿钙、血钙、血磷、雌二醇、中轴骨骨密度以及生活质量。结果 :两组治疗前PTH、尿钙、血钙、血磷、雌二醇、中轴骨骨密度以及生活质量评分无明显变化,无统计学意义。治疗后,观察组血清PTH、尿钙、血钙、血磷、雌二醇值、中轴骨骨密度以及生活质量明显优于对照组,差异有统计学意义。结论 :补肾活血颗粒治疗妇女绝经后骨质疏松症的效果显著,血清PTH、血钙、血磷水平明显降低,尿钙水平逐渐恢复正常,雌二醇水平上升,中轴骨骨密度增加,患者生活质量得到明显提高。
Objective To observe the clinical effect of Bushen Huoxue granule in treating 90 cases of women with postmenopausal osteoporosis. Methods One hundred eighty women with postmenopausal osteoporosis who treated in our hospital from December 2015 to September 2016 were selected, and the patients were randomly divided into the control group and the observation group, 90 cases in each group. Patients in the control group were treated with bone nutrient, while the patients in theobservation group were treated with Bushen Huoxue granule. The serum parathyroid hormone(PTH), urinary calcium, serum calcium, phosphorus, estradiol, axial bone mineral density and quality of life of patients before and after treatment were compared between two groups. Results There were no significant differences in PTH, urinary calcium, serum calcium, phosphorus, estradiol, axial bone mineral density and quality of life before treatment between two groups. After treatment, the PTH, urinary calcium, serum calcium, phosphorus, estradiol, axial bone mineral density and quality of life in the observation group were significantly better than those in the control group, and the differences were statistically significant. Conclusion Bushen Huoxue granule has significant effect in treating women with postmenopausal osteoporosis, it can significantly decrease the serum PTH, serum calcium and phosphorus levels, gradually restore the urinary calcium to normal level, increase the estradiol level and axial bone mineral density, and it can improve the quality of life of patients.
Objective To observe the clinical effect of Bushen Huoxue granule in treating 90 cases of women with postmenopausal osteoporosis. Methods One hundred eighty women with postmenopausal osteoporosis who treated in our hospital from December 2015 to September 2016 were selected, and the patients were randomly divided into the control group and the observation group, 90 cases in each group. Patients in the control group were treated with bone nutrient, while the patients in theobservation group were treated with Bushen Huoxue granule. The serum parathyroid hormone(PTH), urinary calcium, serum calcium, phosphorus, estradiol, axial bone mineral density and quality of life of patients before and after treatment were compared between two groups. Results There were no significant differences in PTH, urinary calcium, serum calcium, phosphorus, estradiol, axial bone mineral density and quality of life before treatment between two groups. After treatment, the PTH, urinary calcium, serum calcium, phosphorus, estradiol, axial bone mineral density and quality of life in the observation group were significantly better than those in the control group, and the differences were statistically significant. Conclusion Bushen Huoxue granule has significant effect in treating women with postmenopausal osteoporosis, it can significantly decrease the serum PTH, serum calcium and phosphorus levels, gradually restore the urinary calcium to normal level, increase the estradiol level and axial bone mineral density, and it can improve the quality of life of patients.
引文
[1]袁明阳,王建伟.中医药治疗骨质疏松症的研究进展[J].世界中医药, 2016, 11(6):1119-1121, 1125.
[2]金桥,牛志军.补肾活血汤联合钙尔奇治疗绝经后原发性骨质疏松症疗效观察[J].四川中医, 2015, 33(6):128-130.
[3]Mohd Effendy N, Abdullah S, Yunoh MF, et al. Time and dose-dependent effects of Labisia pumila on the bone strength of postmenopausal osteoporosis rat model[J]. BMC Complement Altern Med, 2015, 15(1):567.
[4]王国胜,王文鸽,崔炳臣.补肾活血方联合迪巧治疗老年骨质疏松临床分析[J].四川中医, 2014, 33(7):98-100.
[5]Yu J, Goldshtein I, Shalev V, et al. Renal impairment among postmenopausal women with osteoporosis from a large health plan in Israel[J].Archives of Osteoporosis, 2015, 10(1):210.
[6]韩艳,刘娜,吴春雷,等.唑来膦酸配合补肾活血方治疗绝经后骨质疏松临床分析[J].中华全科医学, 2015, 13(3):402, 404.
[7]Suzuki Y, Wakabayashi T. Management of osteoporosis associated with rheumatoid arthritis and glucocorticoidinduced osteoporosis[J]. Clin Calcium, 2015, 25(12):1825-1834.
[8]黄松,陈敬有,高皓.补肾活血方对老年骨质疏松症患者骨密度及相关骨代谢生化指标的影响[J].临床骨科杂志, 2017, 20(5):629, 632.
[9]Lewandowski B, Brodowski R, Kose T, et al. The rare case of osteonecrosis of the jaws in a patient treated with bisphosphonates for osteoporosis[J]. Przegl Lek, 2016, 73(1):46-48.
[10]笪巍伟,马勇,赵永见,等.中药改善原发性骨质疏松性腰背痛疗效及安全性的元分析[J].世界中医药, 2017, 12(10):2482-2486.
[11] Siris E S, Adler R, Bilezikian J, et al. The clinical diagnosis of osteoporosis:a position statement from the National Bone Health Alliance Working Group[J]. Osteoporos Int, 2014, 25(5):1439-1443.
[12]杜旭召,邓素玲,杨豪.补肾活血通络汤治疗糖皮质激素致骨质疏松症临床观察[J].中国实验方剂学杂志, 2017, 23(4):193-197.
[13] Krege JH, Lane NE, Harris JM, et a1. PINP as a biological response marker during teriparatide treatment for osteoporosis[J]. Osteoporos Int,2014, 6(1):39.
[14]姜坤,周强,尚德阳,等.补肾活血方对骨质疏松症模型大鼠骨密度及BMP-2蛋白表达影响实验研究[J].辽宁中医药大学学报,2016, 18(5):20-22.
[15]韩冰.补肾活血汤联合钙尔奇治疗绝经后原发性骨质疏松症疗效观察[J].现代中西医结合杂志, 2016, 25(20):2207-2209.
[2]金桥,牛志军.补肾活血汤联合钙尔奇治疗绝经后原发性骨质疏松症疗效观察[J].四川中医, 2015, 33(6):128-130.
[3]Mohd Effendy N, Abdullah S, Yunoh MF, et al. Time and dose-dependent effects of Labisia pumila on the bone strength of postmenopausal osteoporosis rat model[J]. BMC Complement Altern Med, 2015, 15(1):567.
[4]王国胜,王文鸽,崔炳臣.补肾活血方联合迪巧治疗老年骨质疏松临床分析[J].四川中医, 2014, 33(7):98-100.
[5]Yu J, Goldshtein I, Shalev V, et al. Renal impairment among postmenopausal women with osteoporosis from a large health plan in Israel[J].Archives of Osteoporosis, 2015, 10(1):210.
[6]韩艳,刘娜,吴春雷,等.唑来膦酸配合补肾活血方治疗绝经后骨质疏松临床分析[J].中华全科医学, 2015, 13(3):402, 404.
[7]Suzuki Y, Wakabayashi T. Management of osteoporosis associated with rheumatoid arthritis and glucocorticoidinduced osteoporosis[J]. Clin Calcium, 2015, 25(12):1825-1834.
[8]黄松,陈敬有,高皓.补肾活血方对老年骨质疏松症患者骨密度及相关骨代谢生化指标的影响[J].临床骨科杂志, 2017, 20(5):629, 632.
[9]Lewandowski B, Brodowski R, Kose T, et al. The rare case of osteonecrosis of the jaws in a patient treated with bisphosphonates for osteoporosis[J]. Przegl Lek, 2016, 73(1):46-48.
[10]笪巍伟,马勇,赵永见,等.中药改善原发性骨质疏松性腰背痛疗效及安全性的元分析[J].世界中医药, 2017, 12(10):2482-2486.
[11] Siris E S, Adler R, Bilezikian J, et al. The clinical diagnosis of osteoporosis:a position statement from the National Bone Health Alliance Working Group[J]. Osteoporos Int, 2014, 25(5):1439-1443.
[12]杜旭召,邓素玲,杨豪.补肾活血通络汤治疗糖皮质激素致骨质疏松症临床观察[J].中国实验方剂学杂志, 2017, 23(4):193-197.
[13] Krege JH, Lane NE, Harris JM, et a1. PINP as a biological response marker during teriparatide treatment for osteoporosis[J]. Osteoporos Int,2014, 6(1):39.
[14]姜坤,周强,尚德阳,等.补肾活血方对骨质疏松症模型大鼠骨密度及BMP-2蛋白表达影响实验研究[J].辽宁中医药大学学报,2016, 18(5):20-22.
[15]韩冰.补肾活血汤联合钙尔奇治疗绝经后原发性骨质疏松症疗效观察[J].现代中西医结合杂志, 2016, 25(20):2207-2209.