粉防己碱临床应用研究进展
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摘要
粉防己碱又名汉防己甲素,是一类从防己科植物粉防己的根块中提取出的双苄基异喹啉类生物碱,具有镇痛、抗炎、抗抑郁、抑制纤维化等作用。通过查阅国内外相关文献报道,发现粉防己碱在临床上可用于治疗呼吸系统、神经系统、循环系统、运动系统及其他系统相关疾病,但主要用于减轻症状,需要与相关药物联用,才能更好地发挥临床效果。对粉防己碱的临床应用及剂型的研究进展进行综述,旨在为粉防己碱的进一步开发利用提供科学依据和理论指导。
Tetrandrine also known as tetrandrine,is a kind of bisbenzylisoquinoline alkaloid extracted from the roots of a family of anti-fungal plants.It has analgesic,anti-inflammatory,anti-depressant and inhibition.It can be used as a dosage form such as a tablet,an injection or an eye drop by the action of fibrosis or the like.This article reviews the related literatures at home and abroad.The tetrandrine is clinically applicable to the treatment of related diseases of the respiratory,nervous,circulatory,motor,and other systems,but it has been found that tetrandrine is mainly used in some treatments.To alleviate the symptoms,it is necessary to use some related drugs in order to better play the clinically needed effects.The research progress of clinical application and dosage form of tetrandrine is reviewed,aiming at providing scientific basis and theoretical guidance for the further research and application of tetrandrine.
Tetrandrine also known as tetrandrine,is a kind of bisbenzylisoquinoline alkaloid extracted from the roots of a family of anti-fungal plants.It has analgesic,anti-inflammatory,anti-depressant and inhibition.It can be used as a dosage form such as a tablet,an injection or an eye drop by the action of fibrosis or the like.This article reviews the related literatures at home and abroad.The tetrandrine is clinically applicable to the treatment of related diseases of the respiratory,nervous,circulatory,motor,and other systems,but it has been found that tetrandrine is mainly used in some treatments.To alleviate the symptoms,it is necessary to use some related drugs in order to better play the clinically needed effects.The research progress of clinical application and dosage form of tetrandrine is reviewed,aiming at providing scientific basis and theoretical guidance for the further research and application of tetrandrine.
引文
[1]李燕,赵德发.汉防己甲素改善尘肺患者肺通气功能临床观察[J].职业卫生与病伤,2013,28(1):59-60.
[2]肖维刚,周顺林,吴中秋,等.呼吸功能训练配合汉防己甲素治疗矽肺病疗效观察[J].河北医药,2012,34(12):1828-1829.
[3]汪静.汉防己甲素治疗尘肺病的临床疗效观察[J].北方药学,2015,12(3):52-53.
[4]梁晓飞,王铭,肖永红.粉防己碱对小鼠肺成纤维细胞的凋亡及Caspase-3蛋白的影响[J].中国临床药理学杂志,2016,32(6):531-533.
[5]LIN ZW,ZHONG SZ,LIU DW,et al.Effect of tetrandrine on the TGF-β-induced smad signal transduction pathway in human hypertrophic scar fibroblasts in vitro[J].Burns,2012,38(3):404-413.
[6]白云静,申洪波,姜德训,等.汉防己甲素治疗结缔组织病相关间质性肺疾病临床疗效观察[J].中国医刊,2017,52(3):39-42.
[7]祝莉娜.汉防己甲素联合虫草菌粉和胸腺肽治疗特发性肺间质纤维化的临床疗效比较[J].社区医学杂志,2017,15(5):35-37.
[8]张华,张春玲.大剂量N-乙酰半胱氨酸对染尘大鼠模型的抗氧化作用[J].中国预防医学杂志,2011,12(8):682-685.
[9]文建平,易卫平.汉防己甲素联合大剂量N-乙酰半胱氨酸治疗矽肺疗效观察[J].福建医药杂志,2017,39(1):98-100.
[10]肖韡,洪梅.汉防己甲素对晚期非小细胞肺癌的放疗增敏作用[J].重庆医学,2015,44(24):3362-3364.
[11]廖辰,杨玖,朱诺,等.汉防己甲素预防放射性肺损伤的临床效果观察[J].临床肺科杂志,2016,21(12):2252-2254.
[12]袁项英.大容量全肺灌洗术联合粉防己碱片序贯治疗对Ⅱ期尘肺患者生命质量及氧化应激的影响[J].医疗装备,2017,30(20):139-140.
[13]梁栋,罗莉.汉防己碱滴眼液对慢性高眼压兔模型治疗作用的研究[J].安徽医药,2016,20(12):2238-2241.
[14]张静,沈永青,仇炜,等.粉防己碱诱导人视网膜母细胞瘤细胞凋亡及其机制研究[J].中国癌症杂志,2015,25(12):953-958.
[15]CHEN YH,XIAO X,WANG CC,et al.Beneficial effect of tetrandrine on refractory epilepsy via suppressing P-glycoprotein[J].International Journal of Neuroscience,2015,125(9):703-710.
[16]天津中医药大学.粉防己碱在制备预防和/或治疗抑郁症药物中的应用:中国,CN201110171091.1[P].2011-12-14.
[17]QIN GC,GUI B,XIE JM,et al.Tetrandrine Alleviates Nociception in a Rat Model of Migraine via Suppressing S100Band p-ERK Activation in Satellite Glial Cells of the Trigeminal Ganglia[J].Journal of Molecular Neuroscience,2018,64(1):29-38.
[18]袁俊,漆伟男.粉防己碱对急性脑梗死患者血清胆红素的影响[J].中国当代医药,2014,21(24):55-56,59.
[19]张晓明,郭景春,张玉,等.粉防己碱合用还原型谷胱甘肽对帕金森病大鼠模型神经保护效应的实验研究[C].老年医学学术年会论文汇编,2015:2.
[20]张萌.粉防己碱血管舒张及心肌保护药理作用的研究[D].北京:中国协和医科大学,2008.
[21]张晓斌,李青春,熊玉平.粉防己碱对碱烧伤角膜中基质金属蛋白酶-2的影响[J].时珍国医国药,2017,28(5):1102-1104.
[22]夏朝霞,杨筱曦,冯志贞,等.抑制翼状胬肉术后血管增生免疫纳米微球VEGF McAb-PLA(Tet)-NP的制备方法研究[J].中华眼科医学杂志:电子版,2016,6(3):124-129.
[23]ZHANG TJ,GUO RX,LI X,et al.Tetrandrine cardioprotection in ischemia-reperfusion(I/R)injury via JAK3/STAT3/Hexokinase II[J].European Journal of Pharmacology,2017(813):153-160.
[24]李乾,常亮,苏冬梅,等.粉防己碱对心肌成纤维细胞增殖、活化的影响[J].北京大学学报:医学版,2018,50(2):331-334.
[25]余良主,石春蓉.粉防己碱对高血压大鼠左室心肌营养素-1及其受体gp130/LIFR表达的影响[J].中国实验方剂学杂志,2014,20(11):151-155.
[26]白雪媛,尹翌秋,王彤,等.HPLC法同时测定利心丸中粉防己碱和防己诺林碱含量[J].中华中医药杂志,2017,32(7):3235-3238.
[27]王飞.关节周围骨折手术后汉防己甲素片镇痛效果评价[J].中国矫形外科杂志,2015,23(10):953-955.
[28]LV Q,ZHU XY,XIA YF,et al.Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1,Cdc42,and Rho A GTPases and activation of the PI3K/Akt and JNK signaling pathways[J].Chinese Journal of Natural Medicines,2015,13(11):831-841.
[29]黄静宜,黄振俊,张立俭.汉防己甲素片结合滋肾骨康丸治疗类风湿性关节炎合并骨质疏松症34例[J/OL].河南中医,2015,35(12):2992-2994.
[30]盛有根,夏建洪,徐海波.热敏药灸配合汉防己甲素经皮给药治疗腰椎间盘突出症的疗效观察[J].上海针灸杂志,2018,37(3):320-323.
[31]刘宝瑞,魏嘉,钱晓萍.汉防已甲素作为治疗胃癌的化疗药物增敏剂的应用:中国,CN101011399[P].2007-08-08.
[32]李文化,梅运军,万佳丽,等.一种治疗恶性肿瘤的药物组合物:中国:CN102626412A[P].2012-08-08.
[33]张嵩.消炎镇痛口服滴丸及制备工艺:中国:CN1562161[P].2005-01-12.
[34]上海紫邦生物医药有限公司.粉防己碱/甘草酸二钾在制备抗过敏药物中的应用:中国:CN201410141395.7[P].2014-07-09.
[2]肖维刚,周顺林,吴中秋,等.呼吸功能训练配合汉防己甲素治疗矽肺病疗效观察[J].河北医药,2012,34(12):1828-1829.
[3]汪静.汉防己甲素治疗尘肺病的临床疗效观察[J].北方药学,2015,12(3):52-53.
[4]梁晓飞,王铭,肖永红.粉防己碱对小鼠肺成纤维细胞的凋亡及Caspase-3蛋白的影响[J].中国临床药理学杂志,2016,32(6):531-533.
[5]LIN ZW,ZHONG SZ,LIU DW,et al.Effect of tetrandrine on the TGF-β-induced smad signal transduction pathway in human hypertrophic scar fibroblasts in vitro[J].Burns,2012,38(3):404-413.
[6]白云静,申洪波,姜德训,等.汉防己甲素治疗结缔组织病相关间质性肺疾病临床疗效观察[J].中国医刊,2017,52(3):39-42.
[7]祝莉娜.汉防己甲素联合虫草菌粉和胸腺肽治疗特发性肺间质纤维化的临床疗效比较[J].社区医学杂志,2017,15(5):35-37.
[8]张华,张春玲.大剂量N-乙酰半胱氨酸对染尘大鼠模型的抗氧化作用[J].中国预防医学杂志,2011,12(8):682-685.
[9]文建平,易卫平.汉防己甲素联合大剂量N-乙酰半胱氨酸治疗矽肺疗效观察[J].福建医药杂志,2017,39(1):98-100.
[10]肖韡,洪梅.汉防己甲素对晚期非小细胞肺癌的放疗增敏作用[J].重庆医学,2015,44(24):3362-3364.
[11]廖辰,杨玖,朱诺,等.汉防己甲素预防放射性肺损伤的临床效果观察[J].临床肺科杂志,2016,21(12):2252-2254.
[12]袁项英.大容量全肺灌洗术联合粉防己碱片序贯治疗对Ⅱ期尘肺患者生命质量及氧化应激的影响[J].医疗装备,2017,30(20):139-140.
[13]梁栋,罗莉.汉防己碱滴眼液对慢性高眼压兔模型治疗作用的研究[J].安徽医药,2016,20(12):2238-2241.
[14]张静,沈永青,仇炜,等.粉防己碱诱导人视网膜母细胞瘤细胞凋亡及其机制研究[J].中国癌症杂志,2015,25(12):953-958.
[15]CHEN YH,XIAO X,WANG CC,et al.Beneficial effect of tetrandrine on refractory epilepsy via suppressing P-glycoprotein[J].International Journal of Neuroscience,2015,125(9):703-710.
[16]天津中医药大学.粉防己碱在制备预防和/或治疗抑郁症药物中的应用:中国,CN201110171091.1[P].2011-12-14.
[17]QIN GC,GUI B,XIE JM,et al.Tetrandrine Alleviates Nociception in a Rat Model of Migraine via Suppressing S100Band p-ERK Activation in Satellite Glial Cells of the Trigeminal Ganglia[J].Journal of Molecular Neuroscience,2018,64(1):29-38.
[18]袁俊,漆伟男.粉防己碱对急性脑梗死患者血清胆红素的影响[J].中国当代医药,2014,21(24):55-56,59.
[19]张晓明,郭景春,张玉,等.粉防己碱合用还原型谷胱甘肽对帕金森病大鼠模型神经保护效应的实验研究[C].老年医学学术年会论文汇编,2015:2.
[20]张萌.粉防己碱血管舒张及心肌保护药理作用的研究[D].北京:中国协和医科大学,2008.
[21]张晓斌,李青春,熊玉平.粉防己碱对碱烧伤角膜中基质金属蛋白酶-2的影响[J].时珍国医国药,2017,28(5):1102-1104.
[22]夏朝霞,杨筱曦,冯志贞,等.抑制翼状胬肉术后血管增生免疫纳米微球VEGF McAb-PLA(Tet)-NP的制备方法研究[J].中华眼科医学杂志:电子版,2016,6(3):124-129.
[23]ZHANG TJ,GUO RX,LI X,et al.Tetrandrine cardioprotection in ischemia-reperfusion(I/R)injury via JAK3/STAT3/Hexokinase II[J].European Journal of Pharmacology,2017(813):153-160.
[24]李乾,常亮,苏冬梅,等.粉防己碱对心肌成纤维细胞增殖、活化的影响[J].北京大学学报:医学版,2018,50(2):331-334.
[25]余良主,石春蓉.粉防己碱对高血压大鼠左室心肌营养素-1及其受体gp130/LIFR表达的影响[J].中国实验方剂学杂志,2014,20(11):151-155.
[26]白雪媛,尹翌秋,王彤,等.HPLC法同时测定利心丸中粉防己碱和防己诺林碱含量[J].中华中医药杂志,2017,32(7):3235-3238.
[27]王飞.关节周围骨折手术后汉防己甲素片镇痛效果评价[J].中国矫形外科杂志,2015,23(10):953-955.
[28]LV Q,ZHU XY,XIA YF,et al.Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1,Cdc42,and Rho A GTPases and activation of the PI3K/Akt and JNK signaling pathways[J].Chinese Journal of Natural Medicines,2015,13(11):831-841.
[29]黄静宜,黄振俊,张立俭.汉防己甲素片结合滋肾骨康丸治疗类风湿性关节炎合并骨质疏松症34例[J/OL].河南中医,2015,35(12):2992-2994.
[30]盛有根,夏建洪,徐海波.热敏药灸配合汉防己甲素经皮给药治疗腰椎间盘突出症的疗效观察[J].上海针灸杂志,2018,37(3):320-323.
[31]刘宝瑞,魏嘉,钱晓萍.汉防已甲素作为治疗胃癌的化疗药物增敏剂的应用:中国,CN101011399[P].2007-08-08.
[32]李文化,梅运军,万佳丽,等.一种治疗恶性肿瘤的药物组合物:中国:CN102626412A[P].2012-08-08.
[33]张嵩.消炎镇痛口服滴丸及制备工艺:中国:CN1562161[P].2005-01-12.
[34]上海紫邦生物医药有限公司.粉防己碱/甘草酸二钾在制备抗过敏药物中的应用:中国:CN201410141395.7[P].2014-07-09.