湖州市抗病毒干预对配偶间HIV传播的抑制作用研究
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摘要
目的:分析湖州市抗病毒干预对配偶间HIV传播的抑制作用。方法:回顾性分析308例HIV抗体阳性者及其阴性配偶的临床资料,根据原阳者治疗情况分为抗病毒组(n=158)、未抗病毒组(n=150)。比较两组原阳者年龄、性别、文化程度、感染时间、性行为频率、安全套使用情况,原阳者首次检测及末次随访的白细胞计数(WBC)、红细胞计数(RBC)、红细胞血红蛋白(CH)、红细胞体积(CV)等血液学指标、CD4计数、CD8计数等免疫指标及HIV病毒载量,比较两组患者患者随访时间、随访期间HIV检测次数、随访期间阴性配偶转阳率。结果:两组患者原阳者性别、年龄、文化程度、感染时间、每月性行为次数、安全套使用情况的差异均无统计学意义(均P>0.05)。随访时间及随访期间HIV人均检查次数的差异均无统计学意义(均P>0.05)。两组患者患者随访1年及2年的配偶转阳性率无统计学意义(P>0.05),抗病毒组随访3年的转阳率为0.93%(1/108),低于未抗病毒组的7.69%(8/104),差异具有统计学意义(P<0.05)。抗病毒组与未抗病毒组首次检测时的WBC、RBC、CH、CV、CD4+计数、CD8+计数、HIV载量的差异无统计学意义(P>0.05);抗病毒组末次随访的WBC、RBC、HIV病毒载量低于未抗病毒组,CH、CV、CD4+计数、CD8+计数高于未抗病毒组,差异具有统计学意义(P<0.05)。结论:抗病毒干预可有效抑制病毒复制,改善原阳者贫血症状,促进其免疫力的恢复,有利于降低配偶间HIV传播风险,值得推广。
Objective: To analyze the inhibitory effect of antiviral intervention on the transmission of human immunodeficiency virus( HIV) among spouses in Huzhou. Methods: Retrospective analysis of the clinical data of308 cases of HIV antibody positive and negative spouse was conducted and the subjects were divided into antiviral group( n = 158) and non-antiviral group( n = 150) according to the treatment of the original positive patients.Age,sex,educational level,time of infection of the original positive patients,frequency of sexual behavior,condom use,the hematological indicators of the white blood cell count( WBC),red blood cell count( RBC),erythrocyte hemoglobin( CH),red blood cell volume( CV),the immune indicators of CD4 count,CD8 count,the HIV viral load at first detection and last follow-up,follow-up time,times of HIV tests and the rate of negative spouse turning positive during follow-up were compared between the two groups. Results: There were no significant differences in the age,sex,educational level,time of infection of the original positive patients,frequency of sexual behavior,condom use between the two groups( P > 0. 05). There were no significant differences in the follow-up time,the times of HIV examinations between the two groups( P > 0. 05). There was no significant difference in the rate of negative spouse turning positive between the two groups within 1 year and 2 years follow up( P > 0. 05). The rate of negative spouse turning positive of the antiviral group was 0. 93%( 1/108) within the 3-year follow up,which was lower than7. 69%( 8/104) in the non-antiviral group( P < 0. 05). There were no significant differences in WBC,RBC,CH,CV,CD4 + count,CD8 + count and HIV viral load between the antiviral group and the non-antiviral group at first detection and last follow-up( P > 0. 05). The WBC,RBC and HIV viral load at the last follow-up were lower than those in the non-antiviral group( P < 0. 05),while the CH,CV,CD4 + count,CD8 + count at the last follow-up were higher than those in the non-antiviral group( P < 0. 05). Conclusions: Antiviral intervention can effectively inhibit the virus replication,improve the original positive anemia symptoms,and promote the recovery of immune system,which is conducive to reducing the risk of HIV transmission between spouses and worthy of promoting.
Objective: To analyze the inhibitory effect of antiviral intervention on the transmission of human immunodeficiency virus( HIV) among spouses in Huzhou. Methods: Retrospective analysis of the clinical data of308 cases of HIV antibody positive and negative spouse was conducted and the subjects were divided into antiviral group( n = 158) and non-antiviral group( n = 150) according to the treatment of the original positive patients.Age,sex,educational level,time of infection of the original positive patients,frequency of sexual behavior,condom use,the hematological indicators of the white blood cell count( WBC),red blood cell count( RBC),erythrocyte hemoglobin( CH),red blood cell volume( CV),the immune indicators of CD4 count,CD8 count,the HIV viral load at first detection and last follow-up,follow-up time,times of HIV tests and the rate of negative spouse turning positive during follow-up were compared between the two groups. Results: There were no significant differences in the age,sex,educational level,time of infection of the original positive patients,frequency of sexual behavior,condom use between the two groups( P > 0. 05). There were no significant differences in the follow-up time,the times of HIV examinations between the two groups( P > 0. 05). There was no significant difference in the rate of negative spouse turning positive between the two groups within 1 year and 2 years follow up( P > 0. 05). The rate of negative spouse turning positive of the antiviral group was 0. 93%( 1/108) within the 3-year follow up,which was lower than7. 69%( 8/104) in the non-antiviral group( P < 0. 05). There were no significant differences in WBC,RBC,CH,CV,CD4 + count,CD8 + count and HIV viral load between the antiviral group and the non-antiviral group at first detection and last follow-up( P > 0. 05). The WBC,RBC and HIV viral load at the last follow-up were lower than those in the non-antiviral group( P < 0. 05),while the CH,CV,CD4 + count,CD8 + count at the last follow-up were higher than those in the non-antiviral group( P < 0. 05). Conclusions: Antiviral intervention can effectively inhibit the virus replication,improve the original positive anemia symptoms,and promote the recovery of immune system,which is conducive to reducing the risk of HIV transmission between spouses and worthy of promoting.
引文
[1]段松,杨跃诚,项丽芬,等.云南省德宏州HIV感染者的阴性配偶中新发感染率研究.中华流行病学杂志,2010,31(9):996-1000.
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[3]杨文杰,樊盼英,梁妍,等.2008-2013年河南省艾滋病患者抗病毒治疗对HIV的抑制效果及其影响因素分析.中华预防医学杂志,2015,49(1):13-20.
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[7]李健健,杨绍敏,张米,等.云南省2007-2012年HIV/AIDS高效联合抗病毒治疗效果及药物不良反应分析.中华流行病学杂志,2013,34(10):1045-1046.
[8]孙定勇,刘佳,王奇,等.河南省81例HCV/HIV共感染者接受艾滋病二线抗病毒治疗效果及HIV耐药性分析.中华流行病学杂志,2015,36(6):576-579.
[9]姜袁,张昭,窦亚兰,等.新疆地区男男性行为人群艾滋病自愿咨询检测及安全套使用情况的调查分析.中国性科学,2016,25(2):148-152.
[10]李健,毛宇嵘,汤后林,等.中国艾滋病疫情重点地区HIV单阳家庭抗病毒治疗与及时性及其影响因素分析.中华预防医学杂志,2015,49(7):625-631.
[11]郝连正,朱晓艳,王国永,等.艾滋病抗病毒治疗死亡患者的生存时间及相关因素分析.中华预防医学杂志,2014,48(6):466-470.
[12]Nakigozi G,Makumbi FE,Bwanika JB,et al.Impact of patient-selected care buddies on adherence to HIV care,disease progression,and conduct of daily life among pre-antiretroviral HIV-infected patients in rakai,Uganda:A randomized controlled trial.J Acquir Immune Defic Syndr,2015,70(1):75-82.
[13]Wu F,He X,Guida J,et al.Network stigma towards people living with HIV/AIDS and their caregivers:An egocentric network study.Glob Public Health,2015,10(9):1032-1045.
[14]Rupani MP,Pawar AB,Bansal RK,et al.Cross-sectional study on socio-demographic and clinical correlates of depression among human immunodeficiency virus-positive patients in Surat City,Western India.Asia Pac Psychiatry,2015,7(4):406-418.
[15]李洁,马彦民,孙定勇,等.河南省2006-2010年艾滋病单方阳性配偶阳转状况分析.中华流行病学杂志,2012,33(1):71-74.
[16]齐金蕾,罗红兵,马艳玲,等.云南省家庭内配偶经性传播HIV影响因素调查.中华流行病学杂志,2012,33(2):173-176.
[17]明帅,王岚,王璐,等.驻马店市抗病毒治疗“单阳家庭”夫妻间性传播HIV影响因素分析.中国艾滋病性病,2012,18(5):276-278.
[18]胡晓远,马媛媛,金涛,等.新疆HIV感染者早期抗病毒治疗受性别、配偶/固定性伴感染状况的影响分析.中国妇幼保健,2013,28(21):3452-3454.
[2]杨跃诚,张玉成,曹艳芬,等.云南省德宏州艾滋病病毒感染者/艾滋病患者阴性配偶HIV新发感染研究.中华流行病学杂志,2016,37(4):512-516.
[3]杨文杰,樊盼英,梁妍,等.2008-2013年河南省艾滋病患者抗病毒治疗对HIV的抑制效果及其影响因素分析.中华预防医学杂志,2015,49(1):13-20.
[4]周贵,邓阳,陈怡蓉,等.HIV/AIDS患者在进行抗病毒治疗中的生命质量研究.昆明医科大学学报,2013,34(7):123-126,138.
[5]Dai SY,Liu JJ,Fan YG,et al.Prevalence and factors associated with late HIV diagnosis.J Med Virol,2015,87(6):970-977.
[6]Yang Y,Lewis FM,Wojnar D.Life changes in women infected with HIV by their husbands:An interpretive phenomenological study.J Assoc Nurses AIDS Care,2015,26(5):580-594.
[7]李健健,杨绍敏,张米,等.云南省2007-2012年HIV/AIDS高效联合抗病毒治疗效果及药物不良反应分析.中华流行病学杂志,2013,34(10):1045-1046.
[8]孙定勇,刘佳,王奇,等.河南省81例HCV/HIV共感染者接受艾滋病二线抗病毒治疗效果及HIV耐药性分析.中华流行病学杂志,2015,36(6):576-579.
[9]姜袁,张昭,窦亚兰,等.新疆地区男男性行为人群艾滋病自愿咨询检测及安全套使用情况的调查分析.中国性科学,2016,25(2):148-152.
[10]李健,毛宇嵘,汤后林,等.中国艾滋病疫情重点地区HIV单阳家庭抗病毒治疗与及时性及其影响因素分析.中华预防医学杂志,2015,49(7):625-631.
[11]郝连正,朱晓艳,王国永,等.艾滋病抗病毒治疗死亡患者的生存时间及相关因素分析.中华预防医学杂志,2014,48(6):466-470.
[12]Nakigozi G,Makumbi FE,Bwanika JB,et al.Impact of patient-selected care buddies on adherence to HIV care,disease progression,and conduct of daily life among pre-antiretroviral HIV-infected patients in rakai,Uganda:A randomized controlled trial.J Acquir Immune Defic Syndr,2015,70(1):75-82.
[13]Wu F,He X,Guida J,et al.Network stigma towards people living with HIV/AIDS and their caregivers:An egocentric network study.Glob Public Health,2015,10(9):1032-1045.
[14]Rupani MP,Pawar AB,Bansal RK,et al.Cross-sectional study on socio-demographic and clinical correlates of depression among human immunodeficiency virus-positive patients in Surat City,Western India.Asia Pac Psychiatry,2015,7(4):406-418.
[15]李洁,马彦民,孙定勇,等.河南省2006-2010年艾滋病单方阳性配偶阳转状况分析.中华流行病学杂志,2012,33(1):71-74.
[16]齐金蕾,罗红兵,马艳玲,等.云南省家庭内配偶经性传播HIV影响因素调查.中华流行病学杂志,2012,33(2):173-176.
[17]明帅,王岚,王璐,等.驻马店市抗病毒治疗“单阳家庭”夫妻间性传播HIV影响因素分析.中国艾滋病性病,2012,18(5):276-278.
[18]胡晓远,马媛媛,金涛,等.新疆HIV感染者早期抗病毒治疗受性别、配偶/固定性伴感染状况的影响分析.中国妇幼保健,2013,28(21):3452-3454.