百合知母地黄汤合酸枣仁汤治疗甲亢不寐的临床效果
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摘要
目的观察百合知母地黄汤合酸枣仁汤治疗甲亢不寐的临床效果。方法选取海南省中医院内分泌科门诊及住院部2014年8月~2015年7月收治的56例甲亢不寐患者作为观察对象,按随机数字表法将其分为对照组和治疗组,各28例。对照组患者服用艾司唑仑片,治疗组患者服用百合知母地黄汤合酸枣仁汤,10 d为1个疗程,共2个疗程,观察比较两组治疗效果。结果治疗组总有效率为85.7%,明显高于对照组(57.1%),差异有统计学意义(P<0.05)。治疗组治疗后焦虑自评量表、抑郁自评量表、匹兹堡睡眠质量指数评分显著低于治疗前及对照组治疗后,差异有统计学意义(P<0.05)。结论百合知母地黄汤合酸枣仁汤治疗甲亢不寐效果显著,值得临床推广。
Objective To observe the clinical effect of Baihe Zhimu Dihuang Decoction combined with Suanzaoren Decoction in the treatment of the hyperthyroidism with insomnia. Methods 56 cases of hyperthyroidism with insomnia admitted to Outpatient and Inpatient Department of Endocrinology in Hainan Hospital of Traditional Chinese Medicine from August 2014 to July 2015 were selected as the observation objects, and they were divided into control group and treatment group according to the random number table method, with 28 cases in each group. The control group was treated with the Estazolam Tablets, the treatment group was given Baihe Zhimu Dihuang Decoction combined with Suanzaoren Decoction. 10 days was as one course, total for 2 courses. The effect of the two groups was observed and compared. Results The total effective rate of treatment group was 85.7%, which was higher than that of control group(57.1%), the difference was statistically significant(P < 0.05). The scores of self-rating anxiety scale, self-rating depression scale, Pittsburgh sleep quality index in treatment group after treatment was lower than those before treatment and those of control group after treatment, there were statistically significant differences(P < 0.05). Conclusion The effect of Baihe Zhimu Dihuang Decoction combined with Suanzaoren Decoction in the treatment of hyperthyroidism insomnia is significant, which is worthy of clinical promotion.
Objective To observe the clinical effect of Baihe Zhimu Dihuang Decoction combined with Suanzaoren Decoction in the treatment of the hyperthyroidism with insomnia. Methods 56 cases of hyperthyroidism with insomnia admitted to Outpatient and Inpatient Department of Endocrinology in Hainan Hospital of Traditional Chinese Medicine from August 2014 to July 2015 were selected as the observation objects, and they were divided into control group and treatment group according to the random number table method, with 28 cases in each group. The control group was treated with the Estazolam Tablets, the treatment group was given Baihe Zhimu Dihuang Decoction combined with Suanzaoren Decoction. 10 days was as one course, total for 2 courses. The effect of the two groups was observed and compared. Results The total effective rate of treatment group was 85.7%, which was higher than that of control group(57.1%), the difference was statistically significant(P < 0.05). The scores of self-rating anxiety scale, self-rating depression scale, Pittsburgh sleep quality index in treatment group after treatment was lower than those before treatment and those of control group after treatment, there were statistically significant differences(P < 0.05). Conclusion The effect of Baihe Zhimu Dihuang Decoction combined with Suanzaoren Decoction in the treatment of hyperthyroidism insomnia is significant, which is worthy of clinical promotion.
引文
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[15]王君.酸枣仁汤加减治疗不寐[J].文摘版:医药卫生,2015(8):114.
[16]刘世军,唐志书,崔春利,等.酸枣仁化学成分的研究进展[J].西部中医药,2016,29(9):143-146.
[17]郭亚芳,陆红,顾文忠,等.两合汤治疗肝郁阴虚型不寐病的临床疗效观察[J].世界中医药,2016,11(12):2608-2610,2615.
[18]张凤茹.酸枣仁汤治疗失眠70例疗效观察[J].中国卫生产业,2012,9(19):161.
[19]潘超,郑丰杰.刘景源教授应用经方辨治失眠经验述要[J].环球中医药,2016,9(4):467-469.
[20]张立峰,刘灿仿,徐福鹏,等.基于中医传承辅助系统的含酸枣仁治疗失眠组方规律分析[J].西部中医药,2016,29(9):96-99.
[21]金阳,李飞,李延利.酸枣仁汤对失眠大鼠睡眠时相的影响[J].时珍国医国药,2008,19(6):1355-1356.
[22]王慧,罗坤,武静.酸枣仁汤对失眠大鼠中脑中缝背核神经胶质细胞的影响[J].中国实验方剂学杂志,2012,18(21):235-239.
[23]李玉娟,刘雯,杨静玉,等.酸枣仁汤的镇静催眠作用[J].沈阳医科大学学报,2002,19(2):115-117.
[2]陈灏珠.实用内科学[M].北京:人民卫生出版社,2005:323-341.
[3]中华医学会精神科学会.中国精神疾病分类方案与诊断标准[M].2版.南京:东南大学出版社,1995:307.
[4]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:94.
[5]汪巧玉,林彩云,王列平.穴位按摩联合心理干预对甲亢失眠患者的效果分析[J].中国医学创新,2014,11(30):115-117.
[6]张大炜,王倩,谢皛,等.稳心颗粒对气阴两虚型失眠患者睡眠质量指数的影响[J].国际中医中药杂志,2012,34(12):1110-1111.
[7]冯金星.酸枣仁汤治疗失眠的临床观察[J].中国医药指南,2011,9(28):328-329.
[8]徐劲松,刘继洪,余志映.加味酸枣仁汤治疗阴虚体质失眠症44例临床观察[J].中国中医基础医学杂志,2013,19(12):1491-1493.
[9]张振涛.安神活血汤治疗失眠48例[J].中医研究,2008,21(9):43.
[10]畅晓燕.中药治疗虚证失眠36例体会[J].云南中医中药杂志,2012,11(3):46-47.
[11]向婷婷.从单胺类神经递质与肝血亏虚证失眠相关变化探讨加味酸枣仁汤的调治作用[D].武汉:湖北中医药大学,2012.
[12]易法银,吴爱华.标本兼顾论治甲状腺机能亢进症[J].湖南中医学院学报,2003,23(3):27-28.
[13]王永炎,张天,李迪臣.临床中医内科学(下)[M].北京:北京出版社,1994.
[14]徐建峰.酸枣仁汤加减治疗慢性失眠54例临床观察[J].中国民间疗法,2015,23(9):53-54.
[15]王君.酸枣仁汤加减治疗不寐[J].文摘版:医药卫生,2015(8):114.
[16]刘世军,唐志书,崔春利,等.酸枣仁化学成分的研究进展[J].西部中医药,2016,29(9):143-146.
[17]郭亚芳,陆红,顾文忠,等.两合汤治疗肝郁阴虚型不寐病的临床疗效观察[J].世界中医药,2016,11(12):2608-2610,2615.
[18]张凤茹.酸枣仁汤治疗失眠70例疗效观察[J].中国卫生产业,2012,9(19):161.
[19]潘超,郑丰杰.刘景源教授应用经方辨治失眠经验述要[J].环球中医药,2016,9(4):467-469.
[20]张立峰,刘灿仿,徐福鹏,等.基于中医传承辅助系统的含酸枣仁治疗失眠组方规律分析[J].西部中医药,2016,29(9):96-99.
[21]金阳,李飞,李延利.酸枣仁汤对失眠大鼠睡眠时相的影响[J].时珍国医国药,2008,19(6):1355-1356.
[22]王慧,罗坤,武静.酸枣仁汤对失眠大鼠中脑中缝背核神经胶质细胞的影响[J].中国实验方剂学杂志,2012,18(21):235-239.
[23]李玉娟,刘雯,杨静玉,等.酸枣仁汤的镇静催眠作用[J].沈阳医科大学学报,2002,19(2):115-117.