人感染伪狂犬病病毒(猪疱疹病毒1型)研究进展
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摘要
伪狂犬病病毒感染家猪后可引起死亡或影响其生长繁殖的急性传染病,对养猪业影响巨大。2018年以来,有研究者在基因水平上明确了人感染伪狂犬病病毒病例的存在,证明了该病毒对人类的致病性。本文将对已报道的人感染伪狂犬病病毒病例进行阐释、说明和归纳,并对其可能的致病机制进行介绍。
Pseudorabies virus(PRV) infection in domestic pigs may cause lethality or acute infectious diseases that affect pig growth and reproduction, and has a great impact on pig industry. Since 2018, PRV infection in human body has been identified at the genetic level. It demonstrats that the virus has a pathogenicity to humans. This paper elucidates, explains and summarizes the reported cases of human PRV infection, and introduces the possible pathogenic mechanisms.
Pseudorabies virus(PRV) infection in domestic pigs may cause lethality or acute infectious diseases that affect pig growth and reproduction, and has a great impact on pig industry. Since 2018, PRV infection in human body has been identified at the genetic level. It demonstrats that the virus has a pathogenicity to humans. This paper elucidates, explains and summarizes the reported cases of human PRV infection, and introduces the possible pathogenic mechanisms.
引文
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[2]Hanson RP. The history of pseudorabies in the United States[J]. J Am Vet Med Assoc, 1954, 124(925):259–261.
[3]Ai JW, Weng SS, Cheng Q, et al. Human endophthalmitis caused by pseudorabies virus infection, China, 2017[J]. Emerg Infect Dis, 2018, 24(6):1087-1090.
[4]AnimalandPlantHealthInspectionServiceTechnical.Pseudorabies(Aujeszky's disease)and its eradication[R].Washington D.C., United States Department of Agriculture, 2008, 9-18.
[5]Skinner GR, Ahmad A, Davies JA. The infrequency of transmission of herpesviruses between humans and animals:postulation of an unrecognised protective host mechanism[J]. Comp Immunol Microbiol Infect Dis, 2001, 24(4):255-269.
[6]Jentzsch KD, Schweizer H. Human susceptibility to herpesvirus suis(Aujeszky-virus)5 multiplication of the virus in cultivated human cells[J]. Z Gesamte Hyg, 1970, 16(11):860-866.
[7]Robbins AK, Dorney DJ, Wathen MW, et al. The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus[J]. J Virol, 1987, 61(9):2691–2701.
[8]Sun Y, Luo Y, Wang CH, et al. Control of swine pseudorabies in China:opportunities and limitations[J]. Vet Microbiol, 2016, 183:119-124.
[9]Geraghty RJ, Krummenacher C, Cohen GH, et al. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor[J]. Science, 1998, 280(5369):1618–1620.
[10]Li A, Lu G, Qi J, et al. Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D[J]. PLoS Pathog, 2017, 13(5):e1006314.
[11]Lu G, Hu Y, Wang Q, et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26[J]. Nature, 2013, 500(7461):227–231.
[12]Uddin Khan S, Atanasova KR, Krueger WS, et al. Epidemiology, geographical distribution, and economic consequences of swine zoonoses:a narrative review[J]. Emerg Microbes Infect, 2013, 2(12):e92.
[13]ZimmermanJJ,BerryWJ,BeranGW, etal.Influenceof temperature and age on the recovery of pseudorabies virus from houseflies(Musca domestica)[J]. Am J Vet Res, 1989, 50(9):1471-1474.
[14]Thawley DG, Wright JC. Pseudorabies virus infection in raccoons:a review[J]. J Wildl Dis, 1982, 18(1):113-116.
[15]EhlersB,DuralG,YasmumN, etal.Novelmammalian herpesviruses and lineages with in the Gammaherpesvirinae:cospeciation and interspecies transfer[J]. J Virol, 2008, 82(7):3509-3516.
[16]Muller T, Batza HJ, Schluter H, et al. Eradication of Aujeszky's disease in Germany[J]. J Vet Med B Infect Dis Vet Public Health, 2003, 50(5):207-213.
[17]Hahn EC, Fadl-Alla B, Lichtensteiger CA. Variation of Aujeszky's disease viruses in wild swine in USA[J]. Vet Microbiol, 2010, 143(1):45-51.
[18]MacDiarmid SC. Aujeszky's disease eradication in New Zealand[J]. Aust Vet J, 2000, 78(7):470-471.
[19]华利忠,刘剑锋,冯志新,等.猪伪狂犬病病毒新流行变异毒株的研究进展[J].江苏农业学报,2017,33(2):476-480.
[20]叶晶,朱秀高,侯博,等. 2010-2014年中国5省份猪伪狂犬病野毒抗体检测分析[J].养猪,2014,(5):113.
[21]Yu ZQ, Tong W, Zheng H, et al. Variations in glycoprotein B contribute to immunogenic difference between PRV variant JS-2012 and Bartha-K61[J]. Vet Microbiol, 2017, 208:97-105.
[22]Tao W, Wu T, Chao Y, et al. Construction of an infectious bacterial artificial chromosome clone of a pseudorabies virus variant:reconstituted virus exhibited wild-type properties, in vitro and in vivo[J]. J Virol Methods, 2018, 259:106-115..
[23]Von Ratz ST. Die empfaglichkeit der tier fur paralysis bulbaris infectiosa[J]. Zeitschrift fur Infectionskran-kheiten, 1914, 15:2.
[24]Schukru-Aksel I, Tuncman Z. Aujeskysche erkrankung in der turkei bei mensch und tier[J]. Z Ges Neurol Psychiat, 1940, 169:598-606.
[25]Hussel L, Neubert R, Liebisch A. Uber aujeskysche krankheit in scweinbestanden[J]. Mh Vet Med, 1963, 18:177-181.
[26]Mravak S, Bienzle U, Feldmeier H, et al. Pseudorabies in man[J]. Lancet, 1987, 28:501-502.
[27]Anusz Z, Szweda W, Popko J, et al. Is Aujeszky's disease a zoonosis?[J]. Przeglad Epidemiol, 1992, 46(3):181-186.
[28]Sawitzky D. Transmission, species specificity, and pathogenicity of Aujeszky's disease virus[J]. Arch Virol Suppl, 1997, 13:201-206.
[29]LuoY,LiN,CongX, etal.Pathogenicityandgenomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China[J]. Vet Microbiol, 2014, 174(1-2):107-115.
[30]Ye C, Guo JC, Gao JC, et al. Genomic analyses reveal that partial sequence of an earlier pseudorabies virus in China is originated from a Bartha-vaccine-like strain[J]. Virology, 2016, 491:56-63.
[31]赵伟丽,乌依罕,关鸿志,等.伪狂犬病毒脑炎临床观察与脑脊液二代测序鉴定[J].中华医学杂志,2018,98(15):1152-1157.
[32]吴运谱.猪伪狂犬病的诊断与防治[J].现代畜牧兽医,2013,(8):31-34.
[33]何敬青,尹逊同,郑新华.猪伪狂犬治疗方法的探讨[J].山东畜牧兽医,2009,30(2):48.
[34]慕榕.猪伪狂犬病的诊断和防治[J].畜牧兽医科技信息,2018,11:89-90.
[35]桑福德.热病:桑德福抗微生物治疗指南(第46版)[M].北京:中国协和医科大学出版社,2016:171-172.
[2]Hanson RP. The history of pseudorabies in the United States[J]. J Am Vet Med Assoc, 1954, 124(925):259–261.
[3]Ai JW, Weng SS, Cheng Q, et al. Human endophthalmitis caused by pseudorabies virus infection, China, 2017[J]. Emerg Infect Dis, 2018, 24(6):1087-1090.
[4]AnimalandPlantHealthInspectionServiceTechnical.Pseudorabies(Aujeszky's disease)and its eradication[R].Washington D.C., United States Department of Agriculture, 2008, 9-18.
[5]Skinner GR, Ahmad A, Davies JA. The infrequency of transmission of herpesviruses between humans and animals:postulation of an unrecognised protective host mechanism[J]. Comp Immunol Microbiol Infect Dis, 2001, 24(4):255-269.
[6]Jentzsch KD, Schweizer H. Human susceptibility to herpesvirus suis(Aujeszky-virus)5 multiplication of the virus in cultivated human cells[J]. Z Gesamte Hyg, 1970, 16(11):860-866.
[7]Robbins AK, Dorney DJ, Wathen MW, et al. The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus[J]. J Virol, 1987, 61(9):2691–2701.
[8]Sun Y, Luo Y, Wang CH, et al. Control of swine pseudorabies in China:opportunities and limitations[J]. Vet Microbiol, 2016, 183:119-124.
[9]Geraghty RJ, Krummenacher C, Cohen GH, et al. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor[J]. Science, 1998, 280(5369):1618–1620.
[10]Li A, Lu G, Qi J, et al. Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D[J]. PLoS Pathog, 2017, 13(5):e1006314.
[11]Lu G, Hu Y, Wang Q, et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26[J]. Nature, 2013, 500(7461):227–231.
[12]Uddin Khan S, Atanasova KR, Krueger WS, et al. Epidemiology, geographical distribution, and economic consequences of swine zoonoses:a narrative review[J]. Emerg Microbes Infect, 2013, 2(12):e92.
[13]ZimmermanJJ,BerryWJ,BeranGW, etal.Influenceof temperature and age on the recovery of pseudorabies virus from houseflies(Musca domestica)[J]. Am J Vet Res, 1989, 50(9):1471-1474.
[14]Thawley DG, Wright JC. Pseudorabies virus infection in raccoons:a review[J]. J Wildl Dis, 1982, 18(1):113-116.
[15]EhlersB,DuralG,YasmumN, etal.Novelmammalian herpesviruses and lineages with in the Gammaherpesvirinae:cospeciation and interspecies transfer[J]. J Virol, 2008, 82(7):3509-3516.
[16]Muller T, Batza HJ, Schluter H, et al. Eradication of Aujeszky's disease in Germany[J]. J Vet Med B Infect Dis Vet Public Health, 2003, 50(5):207-213.
[17]Hahn EC, Fadl-Alla B, Lichtensteiger CA. Variation of Aujeszky's disease viruses in wild swine in USA[J]. Vet Microbiol, 2010, 143(1):45-51.
[18]MacDiarmid SC. Aujeszky's disease eradication in New Zealand[J]. Aust Vet J, 2000, 78(7):470-471.
[19]华利忠,刘剑锋,冯志新,等.猪伪狂犬病病毒新流行变异毒株的研究进展[J].江苏农业学报,2017,33(2):476-480.
[20]叶晶,朱秀高,侯博,等. 2010-2014年中国5省份猪伪狂犬病野毒抗体检测分析[J].养猪,2014,(5):113.
[21]Yu ZQ, Tong W, Zheng H, et al. Variations in glycoprotein B contribute to immunogenic difference between PRV variant JS-2012 and Bartha-K61[J]. Vet Microbiol, 2017, 208:97-105.
[22]Tao W, Wu T, Chao Y, et al. Construction of an infectious bacterial artificial chromosome clone of a pseudorabies virus variant:reconstituted virus exhibited wild-type properties, in vitro and in vivo[J]. J Virol Methods, 2018, 259:106-115..
[23]Von Ratz ST. Die empfaglichkeit der tier fur paralysis bulbaris infectiosa[J]. Zeitschrift fur Infectionskran-kheiten, 1914, 15:2.
[24]Schukru-Aksel I, Tuncman Z. Aujeskysche erkrankung in der turkei bei mensch und tier[J]. Z Ges Neurol Psychiat, 1940, 169:598-606.
[25]Hussel L, Neubert R, Liebisch A. Uber aujeskysche krankheit in scweinbestanden[J]. Mh Vet Med, 1963, 18:177-181.
[26]Mravak S, Bienzle U, Feldmeier H, et al. Pseudorabies in man[J]. Lancet, 1987, 28:501-502.
[27]Anusz Z, Szweda W, Popko J, et al. Is Aujeszky's disease a zoonosis?[J]. Przeglad Epidemiol, 1992, 46(3):181-186.
[28]Sawitzky D. Transmission, species specificity, and pathogenicity of Aujeszky's disease virus[J]. Arch Virol Suppl, 1997, 13:201-206.
[29]LuoY,LiN,CongX, etal.Pathogenicityandgenomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China[J]. Vet Microbiol, 2014, 174(1-2):107-115.
[30]Ye C, Guo JC, Gao JC, et al. Genomic analyses reveal that partial sequence of an earlier pseudorabies virus in China is originated from a Bartha-vaccine-like strain[J]. Virology, 2016, 491:56-63.
[31]赵伟丽,乌依罕,关鸿志,等.伪狂犬病毒脑炎临床观察与脑脊液二代测序鉴定[J].中华医学杂志,2018,98(15):1152-1157.
[32]吴运谱.猪伪狂犬病的诊断与防治[J].现代畜牧兽医,2013,(8):31-34.
[33]何敬青,尹逊同,郑新华.猪伪狂犬治疗方法的探讨[J].山东畜牧兽医,2009,30(2):48.
[34]慕榕.猪伪狂犬病的诊断和防治[J].畜牧兽医科技信息,2018,11:89-90.
[35]桑福德.热病:桑德福抗微生物治疗指南(第46版)[M].北京:中国协和医科大学出版社,2016:171-172.