无针注射系统的研究进展与临床应用
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摘要
本文通过回顾无针注射系统的发展历史,汇总无针注射系统的类型、原理及优缺点,总结无针注射系统在临床上的应用,提出无针注射系统的发展前景。
By reviewing the developmental history of needle-free injection system, this paper summarizes the types, principles, advantages and disadvantages of needle-free injection system, summarizes the clinical application of needle-free injection system, then proposes the prospect of needle-free injection system.
By reviewing the developmental history of needle-free injection system, this paper summarizes the types, principles, advantages and disadvantages of needle-free injection system, summarizes the clinical application of needle-free injection system, then proposes the prospect of needle-free injection system.
引文
[1]苏若琼.胰岛素无针注射装置及其护理研究进展[J].护理学杂志,2018,33(14):109.
[2]刘余,赵红,王旭萍,等.无针注射和有针注射预混胰岛素在2型糖尿病强化治疗的临床应用[J].黑龙江医学,2018,42(3):213.
[3]吕凌波,陈玉华,池莲祥,等.无针注射器与诺和笔皮下注射胰岛素对糖尿病患者血糖控制的交叉对照研究[J].内科急危重症杂志,2017,23(3):196.
[4]杨光华,王岩.无针胰岛素注射器在糖尿病患者中的应用[J].实用妇科内分泌杂志,2018,5(11):36.
[5]Samir Mitragotri.Current status and future prospects of needle-free liquid jet injectors[J].Nature Reviews Drug Discovery,2006,5(7):543.
[6]Parent du Chatelet I,Lang J,Schlumberger M,et al.Clinical immunogenicity and tolerance studies of liquid vaccines delivered by jet-injector and a new single-use cartridge(Imule):comparison with standard syringe injection[J].Vaccine,1997,15(4):449-458.
[7]Jackson LA,Austin G,Chen RT,et al.Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needlefree jet injectors[J].Vaccine,2001,19(32):4704.
[8]Canter J,Mackey K,Good LS,et al.An outbreak of hepatitis B associated with jet injections in a weight reduction clinic[J].Arch Intern Med,1990,150(9):1923.
[9]Myron M,Levine.Can needle-free administration of vaccines become the norm in global immunization[J].Nat Med,2003,9(1):101.
[10]Kojic N,Goyal P,Lou CH,et al.An innovative needle-free injection system:comparison to 1mL standard subcutaneous injection[J].AAPS Pharm Sci Tech,2017,18(8):2965-2970.
[11]Abdul M,Reby RKE,Donghee L,et al.Computational fluid dynamics of impinging microjet for a needle-free skin scar treatment system[J].Comput Biol Med,2018,101:20.
[12]Zeng D,Kang Y,Xie L,et al.A mathematical model and experimental verification of optimal nozzle diameter in needle-free injection[J].J Pharm Sci,2018,107(4):1086-1094.
[13]陈凯,周华.弹簧式液体喷射注射过程的建模及实验研究[J].中国生物医学工程学报,2010,29(1):150-154.
[14]陈添禹,王明娣,陈洁.电磁驱动式无针注射器设计及力学和运动仿真[J].中国机械工程,2018,29(7):859-863.
[15]周志益,赵纯亮,陈洪,等.激光驱动无针注射系统研制与初步性能测试[J].激光杂志,2011,32(1):69-70.
[16]Battula N,Menezes V,Hosseini H.A miniature shock wave driven micro-jet injector for needle-free vaccine/drug delivery[J].Biotechnol Bioeng,2016,113(11):2507-2512.
[17]王超然.气动式剂量可调无针注射器的建模分析及结构创新设计[J].当代化工研究,2018,26(2):177-178.
[18]冯利军,熊良才.音圈电机驱动的无针注射系统研究[J].机械与电子,2012,(2):36-38.
[19]陈凯,杨锋雷.基于音圈直线驱动的无针注射技术[J].机械工程学报,2011,47(9):152.
[20]Nick N.L.Do.Design of a portable pulsed power system for needle-free jet injection[D].American:Institute of Electrical and Electronics Engineers,2018.
[21]宋玉琴,蔡坤,安佰平.无针注射器对中性胰岛素注射液含量的影响[J].中国药房,2013,24(45):4253-4255.
[22]王斐.无针注射胰岛素在糖尿病患者中的应用[J].中国卫生标准管理,2018,9(4):69.
[23]许颖.无针胰岛素注射对糖尿病患者血糖及临床事件的影响[J].当代护士,2018,25(20):10-11.
[24]郭红梅,张文杰,步红兵,等.无针注射器在胰岛素过敏患者中使用的效果初探[J].解放军护理杂志,2018,35(5):74-76.
[25]罕若林,徐秀华,周华丽.14例使用无针注射器的糖尿病患者的护理体会[J].世界最新医学信息文摘,2015,15(50):157.
[26]邓书华,刘智平,昝利萍.护理人员胰岛素注射相关针刺伤与注射工具相关性[J].社区医学杂志,2018,16(14):1169-1172.
[27]任天宇,张肖,邢丽,等.无针皮内注射免疫甲型H7N9流感裂解疫苗的免疫效果评价[J].免疫学杂志,2015,31(5):390.
[28]张其春,胡永炜,陈方兰,等.有针麻醉与无针麻醉在小儿包皮环切术中的对比研究[J].中国性科学,2015,24(1):11-13.
[29]Zempsky WT,Schmitz ML,Meyer JM.Safety and efficacy of needle-free powder lidocaine delivery system in adult patients undergoing venipuncture or peripheral venous cannulation[J].Clin J Pain,2016,32(3):211.
[30]刘洋,黄若蓁,陈向东,等.低压无针注射器治疗瘢痕疙瘩的模式研究[J].组织工程与重建外科杂志,2015,11(3):136-138.
[31]石磊,陆振中.高压无针注射技术治疗瘢痕疙瘩疗效观察[J].中国麻风皮肤病杂志,2015,31(9):571.
[32]陈业忠,任文明,刘永生,等.低压无针瘢痕内注射复方倍他米松联合脉冲染料激光治疗瘢痕疙瘩[J].中国美容医学,2016,25(6):14.
[33]Gong Y,Labh S,Jin Y,Needle-free injection of 5-aminolevulinic acid in photodynamic therapy for the treatment of non-melanoma skin cancer[J].Dermatol Ther,2016,29(4):255-262.
[34]Yu J,Dubey S,Kalia YN.Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation[J].Expert Opin Drug Deliv,2018,15(6):559-566.
[35]高君,刘毅,肖文.射频治疗联合无针水光注射在面部年轻化治疗中的应用[J].中国美容医学,2018,27(5):30,32.
[36]Kwon TR,Seok J,Jang JH,et al.Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model[J].Eur J Pharm Biopharma,2016,105(8):69.
[37]Ren H,Yeow BS,Sun J,et al.Electromagnetic needleless injector with halbach array towards intravitreal delivery[J].IEEE Access,2018,6:1268.
[38]吴奇,李文章,黄晶.心肌无针注射的可行性及规律[J].中国老年学杂志,2015,35(4):1004-1006.
[39]吴奇,郑琴,周鹏,等.无针注射移植骨髓间充质干细胞治疗缺血性心脏病的实验研究[J].心脏杂志,2017,29(6):648.
[40]Khoa LD,Quang TN,Toan PD,et al.Needle-free jet versus conventional needle injection for local anesthesia in men undergoing surgical sperm retrieval[M].American:American Society of Andrology,2018:1.
[41]罗远菊,刘宏.无针注射技术在免疫接种领域的应用[J].解放军药学学报,2011,27(3):260-262.
[42]Harris M,Larsen G,Valyi M,et al.Transient neuropathy after needle-free injection outside of recommended sites[J].AIDS,2006,20(5):785.
[2]刘余,赵红,王旭萍,等.无针注射和有针注射预混胰岛素在2型糖尿病强化治疗的临床应用[J].黑龙江医学,2018,42(3):213.
[3]吕凌波,陈玉华,池莲祥,等.无针注射器与诺和笔皮下注射胰岛素对糖尿病患者血糖控制的交叉对照研究[J].内科急危重症杂志,2017,23(3):196.
[4]杨光华,王岩.无针胰岛素注射器在糖尿病患者中的应用[J].实用妇科内分泌杂志,2018,5(11):36.
[5]Samir Mitragotri.Current status and future prospects of needle-free liquid jet injectors[J].Nature Reviews Drug Discovery,2006,5(7):543.
[6]Parent du Chatelet I,Lang J,Schlumberger M,et al.Clinical immunogenicity and tolerance studies of liquid vaccines delivered by jet-injector and a new single-use cartridge(Imule):comparison with standard syringe injection[J].Vaccine,1997,15(4):449-458.
[7]Jackson LA,Austin G,Chen RT,et al.Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needlefree jet injectors[J].Vaccine,2001,19(32):4704.
[8]Canter J,Mackey K,Good LS,et al.An outbreak of hepatitis B associated with jet injections in a weight reduction clinic[J].Arch Intern Med,1990,150(9):1923.
[9]Myron M,Levine.Can needle-free administration of vaccines become the norm in global immunization[J].Nat Med,2003,9(1):101.
[10]Kojic N,Goyal P,Lou CH,et al.An innovative needle-free injection system:comparison to 1mL standard subcutaneous injection[J].AAPS Pharm Sci Tech,2017,18(8):2965-2970.
[11]Abdul M,Reby RKE,Donghee L,et al.Computational fluid dynamics of impinging microjet for a needle-free skin scar treatment system[J].Comput Biol Med,2018,101:20.
[12]Zeng D,Kang Y,Xie L,et al.A mathematical model and experimental verification of optimal nozzle diameter in needle-free injection[J].J Pharm Sci,2018,107(4):1086-1094.
[13]陈凯,周华.弹簧式液体喷射注射过程的建模及实验研究[J].中国生物医学工程学报,2010,29(1):150-154.
[14]陈添禹,王明娣,陈洁.电磁驱动式无针注射器设计及力学和运动仿真[J].中国机械工程,2018,29(7):859-863.
[15]周志益,赵纯亮,陈洪,等.激光驱动无针注射系统研制与初步性能测试[J].激光杂志,2011,32(1):69-70.
[16]Battula N,Menezes V,Hosseini H.A miniature shock wave driven micro-jet injector for needle-free vaccine/drug delivery[J].Biotechnol Bioeng,2016,113(11):2507-2512.
[17]王超然.气动式剂量可调无针注射器的建模分析及结构创新设计[J].当代化工研究,2018,26(2):177-178.
[18]冯利军,熊良才.音圈电机驱动的无针注射系统研究[J].机械与电子,2012,(2):36-38.
[19]陈凯,杨锋雷.基于音圈直线驱动的无针注射技术[J].机械工程学报,2011,47(9):152.
[20]Nick N.L.Do.Design of a portable pulsed power system for needle-free jet injection[D].American:Institute of Electrical and Electronics Engineers,2018.
[21]宋玉琴,蔡坤,安佰平.无针注射器对中性胰岛素注射液含量的影响[J].中国药房,2013,24(45):4253-4255.
[22]王斐.无针注射胰岛素在糖尿病患者中的应用[J].中国卫生标准管理,2018,9(4):69.
[23]许颖.无针胰岛素注射对糖尿病患者血糖及临床事件的影响[J].当代护士,2018,25(20):10-11.
[24]郭红梅,张文杰,步红兵,等.无针注射器在胰岛素过敏患者中使用的效果初探[J].解放军护理杂志,2018,35(5):74-76.
[25]罕若林,徐秀华,周华丽.14例使用无针注射器的糖尿病患者的护理体会[J].世界最新医学信息文摘,2015,15(50):157.
[26]邓书华,刘智平,昝利萍.护理人员胰岛素注射相关针刺伤与注射工具相关性[J].社区医学杂志,2018,16(14):1169-1172.
[27]任天宇,张肖,邢丽,等.无针皮内注射免疫甲型H7N9流感裂解疫苗的免疫效果评价[J].免疫学杂志,2015,31(5):390.
[28]张其春,胡永炜,陈方兰,等.有针麻醉与无针麻醉在小儿包皮环切术中的对比研究[J].中国性科学,2015,24(1):11-13.
[29]Zempsky WT,Schmitz ML,Meyer JM.Safety and efficacy of needle-free powder lidocaine delivery system in adult patients undergoing venipuncture or peripheral venous cannulation[J].Clin J Pain,2016,32(3):211.
[30]刘洋,黄若蓁,陈向东,等.低压无针注射器治疗瘢痕疙瘩的模式研究[J].组织工程与重建外科杂志,2015,11(3):136-138.
[31]石磊,陆振中.高压无针注射技术治疗瘢痕疙瘩疗效观察[J].中国麻风皮肤病杂志,2015,31(9):571.
[32]陈业忠,任文明,刘永生,等.低压无针瘢痕内注射复方倍他米松联合脉冲染料激光治疗瘢痕疙瘩[J].中国美容医学,2016,25(6):14.
[33]Gong Y,Labh S,Jin Y,Needle-free injection of 5-aminolevulinic acid in photodynamic therapy for the treatment of non-melanoma skin cancer[J].Dermatol Ther,2016,29(4):255-262.
[34]Yu J,Dubey S,Kalia YN.Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation[J].Expert Opin Drug Deliv,2018,15(6):559-566.
[35]高君,刘毅,肖文.射频治疗联合无针水光注射在面部年轻化治疗中的应用[J].中国美容医学,2018,27(5):30,32.
[36]Kwon TR,Seok J,Jang JH,et al.Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model[J].Eur J Pharm Biopharma,2016,105(8):69.
[37]Ren H,Yeow BS,Sun J,et al.Electromagnetic needleless injector with halbach array towards intravitreal delivery[J].IEEE Access,2018,6:1268.
[38]吴奇,李文章,黄晶.心肌无针注射的可行性及规律[J].中国老年学杂志,2015,35(4):1004-1006.
[39]吴奇,郑琴,周鹏,等.无针注射移植骨髓间充质干细胞治疗缺血性心脏病的实验研究[J].心脏杂志,2017,29(6):648.
[40]Khoa LD,Quang TN,Toan PD,et al.Needle-free jet versus conventional needle injection for local anesthesia in men undergoing surgical sperm retrieval[M].American:American Society of Andrology,2018:1.
[41]罗远菊,刘宏.无针注射技术在免疫接种领域的应用[J].解放军药学学报,2011,27(3):260-262.
[42]Harris M,Larsen G,Valyi M,et al.Transient neuropathy after needle-free injection outside of recommended sites[J].AIDS,2006,20(5):785.