从细胞信号通路论《黄帝内经》食饮有节益寿之道
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摘要
医家之宗《黄帝内经》提出了"食饮有节"的饮食养生原则,并围绕此阐述了一系列饮食观念,为中华食养体系的构建写下开篇之笔。历代著名医家关于"轻身延年"理论和实践方面的创新和建树,大多与《黄帝内经》有着密切的渊源关系。当今社会随着生活水平的提高和生活压力的增大,饮食不节成为影响现代人寿命的重要因素之一。笔者通过归纳整理近几年国内外文献和中医古籍,从中医传统饮食养生观与分子机制之间关联点出发,从饮食限制和规律饮食两方面出发初步探讨现代医学饮食观念与传统食养观念之间的联系。从而为科学推进当代饮食养生内涵诠释与实践指导提供进一步参考。
Inner Canon of Huangdi proposed the principle of diet,and elaborated a series of dietary concepts on this topic. It lay a foudation for the construction of Chinese dietary and nutrition system,described as"health dietary theory". The innovations and achievements of the famous doctors in the past on the theory and practice of"prolong life spans"are mostly closely related to the Inner Canon of Huangdi. Nowadays,with the improvement of living standard and the pressure,the irregular diet has become a important factor affecting the life span. The author summarizes the domestic and foreign literature and ancient Chinese medical books in recent years. Starting from the links between traditional Chinese medicine and traditional dietary health concepts and molecular mechanisms,the author discusses the relationship between the concept of modern medicine diet and the concept of traditional food from the aspects of dietary restrictions and regular diet. Aiming to provide a scientific basis for promoting scientific definition and practical guidance of contemporary diet regimens reference.
Inner Canon of Huangdi proposed the principle of diet,and elaborated a series of dietary concepts on this topic. It lay a foudation for the construction of Chinese dietary and nutrition system,described as"health dietary theory". The innovations and achievements of the famous doctors in the past on the theory and practice of"prolong life spans"are mostly closely related to the Inner Canon of Huangdi. Nowadays,with the improvement of living standard and the pressure,the irregular diet has become a important factor affecting the life span. The author summarizes the domestic and foreign literature and ancient Chinese medical books in recent years. Starting from the links between traditional Chinese medicine and traditional dietary health concepts and molecular mechanisms,the author discusses the relationship between the concept of modern medicine diet and the concept of traditional food from the aspects of dietary restrictions and regular diet. Aiming to provide a scientific basis for promoting scientific definition and practical guidance of contemporary diet regimens reference.
引文
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[24]向琪,杨方方,王顺清,等.再障生血片对慢性再生障碍性贫血骨髓瘦素与瘦素受体的影响[J].现代医院,2017,17(6):859-862.
[25]Albrecht U.Timing to perfection:the biology of central and peripheral circadian clocks[J].Neuron,2012,74(2):246.
[26]顾晔,黎卫平,邢陈,等.生物钟基因系统功能异常与心血管疾病和消化疾病的关联性机制研究[J].生物技术通讯,2017,28(3):366-371.
[27]王曜晖,赵智权,杜运松,等.昼夜节律与脂质代谢关系的研究进展[J].山东医药,2018(10):99-102.
[28]高倩.钟基因clock功能的研究进展[J].生物学研究进展,2016,47(1):77-80.
[2]Teresa Shipley Feldhausen,王麒.有计划削减卡路里摄入对健康大有裨益[J].中国科技教育,2015(8):63.
[3]李嘉琦,刘淼,吕宪玉,等.80岁以上高龄老人饮食习惯及其与循环系统疾病相关性的调查分析[J].中华保健医学杂志,2016,18(4):288-291.
[4]张新普,薛丹,李敏,等.脾、四肢、经筋及阳虚体质与阳气之间关系的探讨[J].四川中医,2017(3):22-24.
[5]张焱.试论《黄帝内经》中的食养之道[J].中国中医基础医学杂志,2012(4):360-361.
[6]吴伯艳,刘新光,陈维春.雷帕霉素诱导细胞自噬在衰老相关疾病中的作用[J].中国药理学通报,2015,31(1):11-14.
[7]祝扬扬,宁斌,吴远双,等.热量限制对延缓衰老的作用[J].医学分子生物学杂志,2011,8(2):185-188.
[8]姚玉霄,孙少阳,费飞,等.模式生物斑马鱼在衰老生物学中的研究初探[J].广东医学院学报,2016,34(5):443-446.
[9]Kenyon C J.The genetics of ageing[J].Nature,2010,464(7288):504-512.
[10]廖日滔,郭静科,李冰洁,等.自由基相关细胞信号传导的研究进展[J].中国细胞生物学学报,2014(11):1573-1583.
[11]Yee,Yang,Wen,et al.The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C.elegans[J].Cell,2014,157(4):897.
[12]毛玉琴,韩三峰,王立顺.秀丽隐杆线虫中与衰老相关的DAF-2/IGF-1信号通路研究进展[J].上海交通大学学报:医学版,2014,34(6):929-933.
[13]Kenyon C.The plasticity of aging:insights from long-lived mutants[J].Cell,2005,120(4):449-460.
[14]杨杰华.热量限制影响NIT-1细胞胰岛素分泌的调控通路研究[D].汕头:汕头大学,2008.
[15]陆建国,俞松.mTOR信号通路与肿瘤研究进展[J].现代医药卫生,2015(2):199-202.
[16]贺洁宇,刘峰.mTOR信号通路与衰老及衰老相关重大疾病[J].生物化学与生物物理进展,2014,41(3):257-265.
[17]丁亦含,李玉峰.mTOR信号通路与自噬、凋亡之间的相互关系[J].现代医学,2015(6):801-804.
[18]修成奎,雷燕,王强,等.细胞自噬及其对衰老的调节作用[J].中国实验方剂学杂志,2015(16):214-218.
[19]CHEN L,XU B,LIU L,et al.Hydrogen peroxide inhibits mTOR signaling by activation of AMPKαleading to apoptosis of neuronal cells[J].Laboratory investigation;A Journal of Technical Methods and Pathology,2010,90(5):762.
[20]付坤,柳景华.成纤维细胞生长因子在糖脂代谢中的研究进展[J].中华老年心脑血管病杂志,2014,16(5):550-553.
[21]佚名.饱食可诱发纤维芽细胞生长因子的物质大量增长[J].食品科学,2007(1):98-100.
[22]荣小丽,杨建增,王岩.瘦素介导的信号通路研究新进展[J].中国实验诊断学,2016(2):329-331.
[23]张苏江,单安山.营养状况与瘦素水平研究进展[J].中国公共卫生,2008,24(2):236-238
[24]向琪,杨方方,王顺清,等.再障生血片对慢性再生障碍性贫血骨髓瘦素与瘦素受体的影响[J].现代医院,2017,17(6):859-862.
[25]Albrecht U.Timing to perfection:the biology of central and peripheral circadian clocks[J].Neuron,2012,74(2):246.
[26]顾晔,黎卫平,邢陈,等.生物钟基因系统功能异常与心血管疾病和消化疾病的关联性机制研究[J].生物技术通讯,2017,28(3):366-371.
[27]王曜晖,赵智权,杜运松,等.昼夜节律与脂质代谢关系的研究进展[J].山东医药,2018(10):99-102.
[28]高倩.钟基因clock功能的研究进展[J].生物学研究进展,2016,47(1):77-80.