全国中药资源普查女贞子药材质量现状研究
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摘要
目的:了解全国范围内女贞子的质量现状,为完善女贞子的质量控制和安全性评价标准提供依据。方法:依据《中华人民共和国药典》(2015年版)女贞子项下含量测定方法,测定全国第4次中药资源普查所收集的不同产地的48批女贞子样品中特女贞苷含量,应用ICP-MS法测定其21个无机元素的含量,并测定样品的百粒重。结果:4批样品(S2、S23、S29、S47)特女贞苷含量未达到《中华人民共和国药典》(2015年版)项下要求,其百粒重均小于1.80 g,而其他44批样品百粒重均大于等于1.80 g,说明百粒重与样品特女贞苷含量具有相关性,可作为初步评价女贞子质量的方法。4批样品(S3、S36、S15和S30)的有害元素及重金属元素限量超出《药用植物及制剂进出口绿色行业标准》的限量要求,其可能与药材原植物生长基地的土壤、水源等因素有关。结论:全国不同产地的48批女贞子样品整体质量势态较优,本实验数据可为完善女贞子的质量控制及安全性评价提供依据。
Objective:To provide the basis for improving its quality control and safety evaluation standard by understanding the quality status of Ligustri Lucidi fructus in China.Methods:48 batches of LigustriLucidi Fructus samples were collected by the fourth national survey of traditional Chinese medicine resources,whose specnuezhenide conents were determined by the method of the Chinese Pharmacopoeia(2015 Edition).The contents of 21 inorganic elements were determined by ICP-MS,and the 100-grain weights of the samples were determined.Results:Four batches of samples(S2,S23,S29,S47)did not meet the requirements of specnuezhenide of the Chinese Pharmacopoeia(2015 Edition),with 100-grain weights less than 1.80 g.And the other 44 batches of samples were all more than 1.80 g in weight.The results showed that the 100-grain weight was related with the content of specnuezhenide,which could be used as a preliminary method to evaluate the quality of Ligustrum lucidum.The content of harmful elements and heavy metals in four batches of samples(S3,S36,S15 and S30)exceeded the limits of the Green Trade Standard for Import and Export of Medicinal Plants and Preparations,which might be related with the soil and water source of the growth base of the original plant.Conclusion:The overall quality situation of 48 samples from different habitants in China was satisfactory.The experimental data can provide the basis for improving the quality control and safety evaluation of Ligustri Lucidi fructus.
Objective:To provide the basis for improving its quality control and safety evaluation standard by understanding the quality status of Ligustri Lucidi fructus in China.Methods:48 batches of LigustriLucidi Fructus samples were collected by the fourth national survey of traditional Chinese medicine resources,whose specnuezhenide conents were determined by the method of the Chinese Pharmacopoeia(2015 Edition).The contents of 21 inorganic elements were determined by ICP-MS,and the 100-grain weights of the samples were determined.Results:Four batches of samples(S2,S23,S29,S47)did not meet the requirements of specnuezhenide of the Chinese Pharmacopoeia(2015 Edition),with 100-grain weights less than 1.80 g.And the other 44 batches of samples were all more than 1.80 g in weight.The results showed that the 100-grain weight was related with the content of specnuezhenide,which could be used as a preliminary method to evaluate the quality of Ligustrum lucidum.The content of harmful elements and heavy metals in four batches of samples(S3,S36,S15 and S30)exceeded the limits of the Green Trade Standard for Import and Export of Medicinal Plants and Preparations,which might be related with the soil and water source of the growth base of the original plant.Conclusion:The overall quality situation of 48 samples from different habitants in China was satisfactory.The experimental data can provide the basis for improving the quality control and safety evaluation of Ligustri Lucidi fructus.
引文
[1]中华人民共和国药典2015年版.一部[S].2015:45ChP 2015.VolⅠ[S].2010:45
[2]刘亭亭,王萌.女贞子化学成分与药理作用研究进展[J].中国实验方剂学杂志,2014,20(14):228LIU TT,WANG M.Research progress of chemical composition and pharmacological effects of Fructus Figustri Lucidi[J].Chin J Exp Tradit Med Form,2014,20(14):228
[3]孙星衍,孙冯翼.神农本草经[M].太原:山西科学技术出版社,2018SUN XY,SVN FY.Shengnong’s Herbal Classic[M].Taiyuan:Shanxi Science and Technology Publishing House,2018
[4]罗玲英,赵益,吴德智,等.含女贞子中成药的剂型与工艺分析[J].中国药房,2010(23):2199LUO LY,ZHAO Y,WU DZ,et al.Analysis on dosage form and technology of Chinese patent medicine containing Ligustrum lucidum[J].China Pharm,2010,21(23):2199
[5]周祖文.影响中药微量元素的相关因素研究概况[J].微量元素与健康研究,2002,19(1):66ZHOU ZW.Research survey of correlative factor affecting microelement in traditional Chinese medicine[J].Stud Trace Elements Health,2002,19(1):6 6
[6]李倩华,孙淑军,王洋,等.金属元素在中医药研究中的现状[J].世界科学技术-中医药现代化,2015,17(4):901LI QH,SUN SJ,WANG Y,et al.The current research of metal elements in traditional Chinese medicine[J].World Sci Technol Mod Tradit Chin Med,2015,17(4):901
[7]黄祎雯,傅远飞,张保卫.锶对骨代谢影响的研究进展[J].中国口腔种植学杂志,2010,15(3):153HUANG YW,FU YF,ZHANG BW.Progress in research on the effects of stro ntium on the bone metabolism[J].Chin J Oral Implantol,2010,15(3):153
[8]李云桥,汪金峰,葛晶.雷奈酸锶对绝经后妇女骨质疏松症性骨痛及骨密度和骨代谢的影响[J].中国医院药学杂志,2012,32(22):1822LI YQ,WANG JF,GE J.Effect of strontium ranelate on osteoporotic bone pain and bone mineral density and bone metabolism in women with postmenopausal osteoporosis[J].Chin Hosp Pharm J,2012,32(22):1822
[9]严寒静,房志坚,余世孝.不同地区何首乌无机元素含量的比较[J].应用与环境生物学报,2007,13(3):313YAN HJ,FANG ZJ,YU SX.Comparison of inorganic element contents in Fallopia multiflora Root in different areas[J].Chin JAppl Environ Biol,2007,13(3):313
[10]罗炳锵.中药微量元素的作用[J].中药材,1990,13(2):41LUO BQ.The effect of trace elements in traditional Chinese medicine[J].J Chin Med Mater,1990,13(2):41
[11]曾白林,陈启霞,居明乔.微量元素与中药功效的相关性分析[J].时珍国医国药,2001,12(7):658ZENG BL,CHEN QX,JU MQ.The correlation analysis between trace elements and efficacy of traditional Chinese medicine[J].Lishizhen Med Mater Med Res,2001,12(7):658
[12]缪军强,刘国钢,仇小月,等.女贞子中几种矿物元素积累变化[J].安徽科技学院学报,2016,30(4):21MIU JQ,LIU GG,QIU XY,et al.Several kinds of mineral elements in Ligustri Lucidi Fructus accumulation change[J].J Anhui Sci Technol Univ,2016,30(4):21
[2]刘亭亭,王萌.女贞子化学成分与药理作用研究进展[J].中国实验方剂学杂志,2014,20(14):228LIU TT,WANG M.Research progress of chemical composition and pharmacological effects of Fructus Figustri Lucidi[J].Chin J Exp Tradit Med Form,2014,20(14):228
[3]孙星衍,孙冯翼.神农本草经[M].太原:山西科学技术出版社,2018SUN XY,SVN FY.Shengnong’s Herbal Classic[M].Taiyuan:Shanxi Science and Technology Publishing House,2018
[4]罗玲英,赵益,吴德智,等.含女贞子中成药的剂型与工艺分析[J].中国药房,2010(23):2199LUO LY,ZHAO Y,WU DZ,et al.Analysis on dosage form and technology of Chinese patent medicine containing Ligustrum lucidum[J].China Pharm,2010,21(23):2199
[5]周祖文.影响中药微量元素的相关因素研究概况[J].微量元素与健康研究,2002,19(1):66ZHOU ZW.Research survey of correlative factor affecting microelement in traditional Chinese medicine[J].Stud Trace Elements Health,2002,19(1):6 6
[6]李倩华,孙淑军,王洋,等.金属元素在中医药研究中的现状[J].世界科学技术-中医药现代化,2015,17(4):901LI QH,SUN SJ,WANG Y,et al.The current research of metal elements in traditional Chinese medicine[J].World Sci Technol Mod Tradit Chin Med,2015,17(4):901
[7]黄祎雯,傅远飞,张保卫.锶对骨代谢影响的研究进展[J].中国口腔种植学杂志,2010,15(3):153HUANG YW,FU YF,ZHANG BW.Progress in research on the effects of stro ntium on the bone metabolism[J].Chin J Oral Implantol,2010,15(3):153
[8]李云桥,汪金峰,葛晶.雷奈酸锶对绝经后妇女骨质疏松症性骨痛及骨密度和骨代谢的影响[J].中国医院药学杂志,2012,32(22):1822LI YQ,WANG JF,GE J.Effect of strontium ranelate on osteoporotic bone pain and bone mineral density and bone metabolism in women with postmenopausal osteoporosis[J].Chin Hosp Pharm J,2012,32(22):1822
[9]严寒静,房志坚,余世孝.不同地区何首乌无机元素含量的比较[J].应用与环境生物学报,2007,13(3):313YAN HJ,FANG ZJ,YU SX.Comparison of inorganic element contents in Fallopia multiflora Root in different areas[J].Chin JAppl Environ Biol,2007,13(3):313
[10]罗炳锵.中药微量元素的作用[J].中药材,1990,13(2):41LUO BQ.The effect of trace elements in traditional Chinese medicine[J].J Chin Med Mater,1990,13(2):41
[11]曾白林,陈启霞,居明乔.微量元素与中药功效的相关性分析[J].时珍国医国药,2001,12(7):658ZENG BL,CHEN QX,JU MQ.The correlation analysis between trace elements and efficacy of traditional Chinese medicine[J].Lishizhen Med Mater Med Res,2001,12(7):658
[12]缪军强,刘国钢,仇小月,等.女贞子中几种矿物元素积累变化[J].安徽科技学院学报,2016,30(4):21MIU JQ,LIU GG,QIU XY,et al.Several kinds of mineral elements in Ligustri Lucidi Fructus accumulation change[J].J Anhui Sci Technol Univ,2016,30(4):21