替罗非班不同给药途径对急性心肌梗死的治疗效果
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摘要
目的:研究替罗非班不同给药途径对急性心肌梗死患者的治疗效果。方法:104例急性心肌梗死患者以随机数字表法分为对照组和观察组,每组各52例。对照组采取静脉注射替罗非班,观察组实施冠脉内超声注射替罗非班,比较两组急性心肌梗死患者的临床治疗效果、TIMI血流分级情况、CTFC、术后左心室功能、不良事件发生率。结果:观察组急性心肌梗死患者的总有效率高于对照组(P<0.05);治疗后的TIMI血流为3级的比例高于对照组(P<0.05);治疗后的CTFC、LVEDD、LVESD、不良事件发生率均低于对照组,EF高于对照组数据(P<0.05)。结论:冠脉内超声注射治疗急性心肌梗死患者的效果相较于静脉注射替罗非班治疗更加优越,患者TIMI血流分级情况、CTFC、左心室功能改善更为明显,且能够减少不良事件的发生,临床安全性更高。
Objective:To study the of tirofiban on patients with acute myocardial infarction(AMI).Methods:104 patients with AMI were randomly divided into control group(n=52) and observation group(n=52).The control group was given tirofiban intravenously and the observation group received intra-coronary ultrasound injection of tirofiban.The clinical efficacy,TIMI blood flow grading,CTFC,left ventricular function and incidence of adverse events were compared between the two groups.Results:The total clinical effective rate of the patients with AMI in the observation group was higher than that of the control group(P<0.05),and the ratio of TIMI blood flow grade 3 after treatment was higher than that in the control group(P<0.05).After treatment,the incidence of CTFC,LVEDD,LVESD and adverse events was lower than that of the control group,and EF was higher than that of the control group(P<0.05).Conclusion:The effect of intracoronary ultrasound injection on patients with AMI is better than that of intravenous tirofiban.The TIMI blood flow classification and left ventricular function improvement are more obvious,it can also reduce the occurrence of adverse events and has higher clinical safety.
Objective:To study the of tirofiban on patients with acute myocardial infarction(AMI).Methods:104 patients with AMI were randomly divided into control group(n=52) and observation group(n=52).The control group was given tirofiban intravenously and the observation group received intra-coronary ultrasound injection of tirofiban.The clinical efficacy,TIMI blood flow grading,CTFC,left ventricular function and incidence of adverse events were compared between the two groups.Results:The total clinical effective rate of the patients with AMI in the observation group was higher than that of the control group(P<0.05),and the ratio of TIMI blood flow grade 3 after treatment was higher than that in the control group(P<0.05).After treatment,the incidence of CTFC,LVEDD,LVESD and adverse events was lower than that of the control group,and EF was higher than that of the control group(P<0.05).Conclusion:The effect of intracoronary ultrasound injection on patients with AMI is better than that of intravenous tirofiban.The TIMI blood flow classification and left ventricular function improvement are more obvious,it can also reduce the occurrence of adverse events and has higher clinical safety.
引文
[1] 杨健,罗瑛,李淑均.替罗非班不同给药途径对急性心肌梗死患者的临床疗效分析[J].医学临床研究,2015,32(4):718-720.
[2] 刘继文,汤曾耀,王新旺,等.替罗非班给药途径及时机对急性心肌梗死患者术中无复流的影响[J].中国循证心血管医学杂志,2017,9(5):556-558.
[3] 陈廷春.替罗非班不同给药途径治疗急性心肌梗死效果观察[J].中国卫生标准管理,2016,7(7):104-105.
[4] 彭熠,杨莹莹,刘桐华.替罗非班不同给药途径对急性心肌梗死患者的疗效观察[J].中西医结合心血管病电子杂志,2016,4(13):1-2.
[5] 何小萍,苏少辉,叶健烽,等.冠状动脉闭塞段注入替罗非班对急性心肌梗死合并糖尿病患者血流影响的临床分析[J].中国心血管杂志,2016,21(3):64-69.
[6] 李玉敏.盐酸替罗非班对急性心肌梗死直接PCI术无/慢复流患者疗效分析[J].中国实用医刊,2017,44(2):4-6.
[7] 赵丹.替罗非班对急性心肌梗死后白介素-17的表达及其与室性心律失常的相关性分析[J].中西医结合心脑血管病杂志,2016,14(22):2651-2654.
[8] 郑奇斌,陈克俭,徐翔,等.急性冠脉综合征患者PCI中不同给药途径应用替罗非班有效性及安全性的Meta分析[J].中国心血管病研究,2015,13(6):510-515.
[9] 苟成钢,孙同文.急性冠脉综合征病人PCI术中不同给药途径应用替罗非班有效性与安全性的Meta分析[J].中西医结合心脑血管病杂志,2017,15(4):393-398.
[10] 马欣,于付生,苏毅.替罗非班不同应用途径对老年STEMI急诊PCI术后的疗效观察[J].中国循证心血管医学杂志,2017,9(3):283-285.
[11] 潘港,徐细平,冯小坚,等.替罗非班不同给药方式对STEMI患者急诊PCI效果的影响[J].山东医药,2015,55(41):38-40.
[12] 贾国力,邢程,周倩.高负荷剂量替罗非班在急性ST段抬高型心肌梗死急诊介入治疗中的应用探讨[J].中国医师进修杂志,2015,38(2):134-137.
[13] 潘庆丽,霍本良,王立旗,等.替罗非班在急性心肌梗死急诊PCI中的应用效果分析[J].中国循证心血管医学杂志,2017,9(5):609-611.
[14] 苟成钢,孙同文.急性冠脉综合征病人PCI术中不同给药途径应用替罗非班有效性与安全性的Meta分析[J].中西医结合心脑血管病杂志,2017,15(4):393-398.
[15] 黄燕妮,李绪洪,王晓群.不同剂量替罗非班联合PCI治疗早期肾功能不全急性心肌梗死效果分析[J].青岛医药卫生,2016,48(5):359-360.
[2] 刘继文,汤曾耀,王新旺,等.替罗非班给药途径及时机对急性心肌梗死患者术中无复流的影响[J].中国循证心血管医学杂志,2017,9(5):556-558.
[3] 陈廷春.替罗非班不同给药途径治疗急性心肌梗死效果观察[J].中国卫生标准管理,2016,7(7):104-105.
[4] 彭熠,杨莹莹,刘桐华.替罗非班不同给药途径对急性心肌梗死患者的疗效观察[J].中西医结合心血管病电子杂志,2016,4(13):1-2.
[5] 何小萍,苏少辉,叶健烽,等.冠状动脉闭塞段注入替罗非班对急性心肌梗死合并糖尿病患者血流影响的临床分析[J].中国心血管杂志,2016,21(3):64-69.
[6] 李玉敏.盐酸替罗非班对急性心肌梗死直接PCI术无/慢复流患者疗效分析[J].中国实用医刊,2017,44(2):4-6.
[7] 赵丹.替罗非班对急性心肌梗死后白介素-17的表达及其与室性心律失常的相关性分析[J].中西医结合心脑血管病杂志,2016,14(22):2651-2654.
[8] 郑奇斌,陈克俭,徐翔,等.急性冠脉综合征患者PCI中不同给药途径应用替罗非班有效性及安全性的Meta分析[J].中国心血管病研究,2015,13(6):510-515.
[9] 苟成钢,孙同文.急性冠脉综合征病人PCI术中不同给药途径应用替罗非班有效性与安全性的Meta分析[J].中西医结合心脑血管病杂志,2017,15(4):393-398.
[10] 马欣,于付生,苏毅.替罗非班不同应用途径对老年STEMI急诊PCI术后的疗效观察[J].中国循证心血管医学杂志,2017,9(3):283-285.
[11] 潘港,徐细平,冯小坚,等.替罗非班不同给药方式对STEMI患者急诊PCI效果的影响[J].山东医药,2015,55(41):38-40.
[12] 贾国力,邢程,周倩.高负荷剂量替罗非班在急性ST段抬高型心肌梗死急诊介入治疗中的应用探讨[J].中国医师进修杂志,2015,38(2):134-137.
[13] 潘庆丽,霍本良,王立旗,等.替罗非班在急性心肌梗死急诊PCI中的应用效果分析[J].中国循证心血管医学杂志,2017,9(5):609-611.
[14] 苟成钢,孙同文.急性冠脉综合征病人PCI术中不同给药途径应用替罗非班有效性与安全性的Meta分析[J].中西医结合心脑血管病杂志,2017,15(4):393-398.
[15] 黄燕妮,李绪洪,王晓群.不同剂量替罗非班联合PCI治疗早期肾功能不全急性心肌梗死效果分析[J].青岛医药卫生,2016,48(5):359-360.