高血糖症的炎症机制研究进展
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摘要
高血糖症属于内分泌系统的常见病。近年来其发病率越来越高,严重影响了人们的健康,因此探讨其发病机制非常重要。导致高血糖症的因素众多,越来越多的研究表明慢性炎症是高血糖症发生发展的一个重要因素。借助分子生物学、免疫学等技术,人们对慢性炎症在血糖升高的机制中做了初步的探讨。笔者就高血糖症的炎症机制研究进展进行综述。
Hyperglycemia is a common disease of the endocrine system. Its incidence is getting higher and higher and it seriously affects the health of people in recent years. So it is very important to explore the pathogenesis of hyperglycemia. There are many factors leading to hyperglycemia and many studies have shown that chronic inflammation is an important reason in the development of hyperglycemia.People have made a preliminary study on chronic inflammation in the mechanism of elevated blood glucose through molecular biology,immunology and other techniques.The progress on the inflammation of hyperglycemia is summarized in the paper.
Hyperglycemia is a common disease of the endocrine system. Its incidence is getting higher and higher and it seriously affects the health of people in recent years. So it is very important to explore the pathogenesis of hyperglycemia. There are many factors leading to hyperglycemia and many studies have shown that chronic inflammation is an important reason in the development of hyperglycemia.People have made a preliminary study on chronic inflammation in the mechanism of elevated blood glucose through molecular biology,immunology and other techniques.The progress on the inflammation of hyperglycemia is summarized in the paper.
引文
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[15]Caruana J A,Camara D S,Schneeberger G J,et al.The clearance capacity of the canine liver for a portal vein endotoxin infusion[J].Journal of Surgical Research,1984,37(3):197-201.
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[17]曹英华.辛伐他汀对C反应蛋白及胰岛素抵抗的影响[D].吉林:吉林大学,2005.
[18]Faam B,Zarkesh M,Daneshpour M S,et al.The association between inflammatory markers and obesity-related factors in Tehranian adults:Tehran lipid and glucose study[J].Iranian Journal of Basic Medical Science,2014,17(8):577-582.
[19]Rotter V,Nagaev I,Smith U.Interleukin-6(IL-6)induces insulin resistance in 3T3-L1 adipocytes and is,like IL-8 and tumor necrosis factor-alpha,overexpressed in human fat cells from insulin-resistant subjects[J].Journal of Biological Chemistry,2003,278(46):45777-45784.
[20]施毕旻,成兴波.脂联素、IL-6与2型糖尿病胰岛素抵抗及大血管病变的关系[J].苏州大学学报:医学版,2006,26(1):73-75.
[21]Hotamisligil G S,Shargill N S,Spiegelman B M.Adipose expression of tumor necrosis factor-alpha:direct role in obesity-linked insulin resistance.[J].Science,1993,259(5091):87-91.
[22]Feingold K R,Grunfeld C.Role of cytokines in inducing hyperlipidemia[J].Diabetes,1992,41(Suppl 2):97-101.
[23]Uysal K T,Wiesbrock S M,Marino M W,et al.Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.[J].Nature,1997,389(6651):610-614.
[2]叶翎,孙国燕,孙玉瑶,等.慢性低度炎症与糖尿病关系的研究进展[J].医学综述,2014,20(21):3846-3848.
[3]朱禧星.炎症标志物可预测2型糖尿病发生[J].国际内分泌代谢杂志,2003,23(3):164-165.
[4]Shoelson S E,Lee J,Goldfine A B.Inflammation and insulin resistance[J].Journal of Clinical Investigation,2006,116(7):1793-801.
[5]曾建琼,王桂萍,程青虹.脓毒血症患者血糖与预后的关系[J].检验医学,2016,31(2):95-98.
[6]Ren J,Chen Y B,Zhang Y Y,et al.Decreased circulating neopterin is associated with increased arterial elasticity:a beneficial role of periodontal treatment[J].Australian Dental Journal,2015,61(1):76-83.
[7]Solomon D H,Massarotti E,Garg R,et al.Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis[J].JAMA,2011,305(24):2525-2531.
[8]Gore D C,Jahoor F,Hibbert J M,et al.Lactic acidosis during sepsis is related to increased pyruvate production,not deficits in tissue oxygen availability[J].Annals of Surgery,1996,224(1):97-102.
[9]Lang C H,Bagby G J,Blakesley H L,et al.Glucose kinetics and pyruvate dehydrogenase activity in septic rats treated with dichloroacetate[J].Circulatory Shock,1987,23(2):131-141.
[10]Mcguinness O P.Defective glucose homeostasis during infection[J].Annual Review of Nutrition,2005,25(25):9-35.
[11]Fong Y M,Marano M A,Moldawer L L,et al.The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans[J].Journal of Clinical Investigation,1990,85(6):1896-1904.
[12]Severin P N,Uhing M R,Beno D W,et al.Endotoxin-induced hyperlactatemia results from decreased lactate clearance in hemodynamically stable rats[J].Critical Care Medicine,2002,30(11):2509-2514.
[13]Feingold K R,Moser A,Shigenaga J K,et al.Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue[J].Innate Immunity,2012,18(2):231-240.
[14]Okin D,Medzhitov R.The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia[J].Cell,2016,165(2):343-356.
[15]Caruana J A,Camara D S,Schneeberger G J,et al.The clearance capacity of the canine liver for a portal vein endotoxin infusion[J].Journal of Surgical Research,1984,37(3):197-201.
[16]Pickup J C,Crook M A.Is Type II diabetes mellitus a disease of the innate immune system[J].Diabetologia,1998,41(10):1241-1248.
[17]曹英华.辛伐他汀对C反应蛋白及胰岛素抵抗的影响[D].吉林:吉林大学,2005.
[18]Faam B,Zarkesh M,Daneshpour M S,et al.The association between inflammatory markers and obesity-related factors in Tehranian adults:Tehran lipid and glucose study[J].Iranian Journal of Basic Medical Science,2014,17(8):577-582.
[19]Rotter V,Nagaev I,Smith U.Interleukin-6(IL-6)induces insulin resistance in 3T3-L1 adipocytes and is,like IL-8 and tumor necrosis factor-alpha,overexpressed in human fat cells from insulin-resistant subjects[J].Journal of Biological Chemistry,2003,278(46):45777-45784.
[20]施毕旻,成兴波.脂联素、IL-6与2型糖尿病胰岛素抵抗及大血管病变的关系[J].苏州大学学报:医学版,2006,26(1):73-75.
[21]Hotamisligil G S,Shargill N S,Spiegelman B M.Adipose expression of tumor necrosis factor-alpha:direct role in obesity-linked insulin resistance.[J].Science,1993,259(5091):87-91.
[22]Feingold K R,Grunfeld C.Role of cytokines in inducing hyperlipidemia[J].Diabetes,1992,41(Suppl 2):97-101.
[23]Uysal K T,Wiesbrock S M,Marino M W,et al.Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.[J].Nature,1997,389(6651):610-614.