现代解毒抗癌中药治疗大肠癌研究进展
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摘要
大肠癌是全球常见恶性肿瘤,中医药在大肠癌的治疗中发挥了积极的作用。现代中医发展了癌毒的病机,解毒已成为治疗大肠癌的重要治法;同时发掘拓展了解毒抗癌中药资源,如山慈菇、藤梨根、猫人参、龙葵、白英、冬凌草、土牛膝、墓头回、蛇莓、鬼针草、山海螺、羊蹄根、杠板归、肿节风、了哥王等。这些中药在大肠癌中有广泛的抗癌作用,可以抑制细胞增殖,阻滞细胞周期,诱导细胞凋亡、失巢凋亡、细胞衰老和自噬,抑制转移能力和血管生成,改善免疫功能。山慈菇和白英等中药对大肠癌细胞还具有细胞毒作用。深入研究并合理利用这些中药,将有助于提高大肠癌临床疗效。
Colorectal carcinoma is a common malignancy disease in worldwide. Traditional Chinese medicine( TCM) has played an important role in the treatment of colorectal cancer. Modern TCM scientists have developed the TCM pathogenesis of cancerous toxicity,and detoxifying has become an important therapeutic principle for colorectal carcinoma treatment. At the same time,modern TCM physicians have developed detoxifying anticancer herbs resources,including Pseudobulbus Cremastrae seu Pleiones,Actinidia chinensis Planch,Actinidia valvata Dunn,Herba Solani Nigri,Herba Solani,Rabdosiarubescens( Hemsl.)Hara,Radix Cyathulae,Patrinia heterophylla Bunge,Duchesnea indica( Andr.) Focke,Bidens pilosa L.,Codonopsis lanceolata( Sieb. et Zucc.) Trautv.,Rumex japonicus Meisn,Polygonum perfoliatumL.,Sarcandra glabra( Thunb.) Nakai and Wikstroemia indica. These herbs have demonstrated extensive anti-cancer effects against colorectal cancer,which can inhibit cell proliferation,arrest cell cycle,induce apoptosis,anoikis,cell senescence and autophagy,inhibit angiogenesis and metastatic potential,and improve immune function. In addition,some of those herbs,such as Pseudobulbus Cremastrae seu Pleiones and Herba Solani have cytotoxic effects against colorectal cancer cells. Further explorations and rational application of these herbs will improve the clinical efficacy of colorectal cancer.
Colorectal carcinoma is a common malignancy disease in worldwide. Traditional Chinese medicine( TCM) has played an important role in the treatment of colorectal cancer. Modern TCM scientists have developed the TCM pathogenesis of cancerous toxicity,and detoxifying has become an important therapeutic principle for colorectal carcinoma treatment. At the same time,modern TCM physicians have developed detoxifying anticancer herbs resources,including Pseudobulbus Cremastrae seu Pleiones,Actinidia chinensis Planch,Actinidia valvata Dunn,Herba Solani Nigri,Herba Solani,Rabdosiarubescens( Hemsl.)Hara,Radix Cyathulae,Patrinia heterophylla Bunge,Duchesnea indica( Andr.) Focke,Bidens pilosa L.,Codonopsis lanceolata( Sieb. et Zucc.) Trautv.,Rumex japonicus Meisn,Polygonum perfoliatumL.,Sarcandra glabra( Thunb.) Nakai and Wikstroemia indica. These herbs have demonstrated extensive anti-cancer effects against colorectal cancer,which can inhibit cell proliferation,arrest cell cycle,induce apoptosis,anoikis,cell senescence and autophagy,inhibit angiogenesis and metastatic potential,and improve immune function. In addition,some of those herbs,such as Pseudobulbus Cremastrae seu Pleiones and Herba Solani have cytotoxic effects against colorectal cancer cells. Further explorations and rational application of these herbs will improve the clinical efficacy of colorectal cancer.
引文
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[2]Siegel R L,Miller K D,Jemal A.Cancer statistics,2017[J].CACancer J Clin,2017,67(1):7-30.
[3]魏蒙蒙,胡兵,沈克平.中医药防治大肠癌作用研究[J].中华中医药杂志,2014,29(8):2556-2559.
[4]Deng S,Hu B,An H M.Traditional Chinese medicinal syndromes and treatment in colorectal cancer[J].J Cancer Ther,2012,3(6):888-897.
[5]邓珊,胡兵,沈克平.大肠癌中医病机与治疗研究[J].世界科学技术-中医药现代化,2012,14(4):1858-1862.
[6]魏蒙蒙,胡兵,沈克平.不同治法中药防治大肠癌实验研究进展[J].中药材,2013,36(8):1371-1375.
[7]陶锋,张如松.杠板归的体内外抗肿瘤作用实验研究[J].中华中医药学刊,2013,31(9):2019-2021.
[8]邵萌,黄晓君,孙学刚,等.了哥王根茎中的酚性成分及其抗肿瘤活性研究[J].天然产物研究与开发,2014,26(6):851-855.
[9]Jin H,Tan X,Liu X,et al.Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer:studies in vitro and in vivo[J].J Gastroenterol Hepatol,2011,26(4):706-715.
[10]Ren C M,Li Y,Chen Q Z,et al.Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK[J].Oncol Rep,2016,35(5):2691-2698
[11]金星镜,丁文评,张莲,等.冬凌草甲素对人结肠癌细胞株HCT116生长的影响及其机制研究[J].现代生物医学进展,2014,14(23):4444-4446.
[12]Hsu S C,Lu J H,Kuo C L,et al.Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line(colo 205)[J].Anticancer Res,2008,28(2A):1045-1054.
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[14]Wang L,Xu M L,Hu J H,et al.Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29cells-Involvement of ROS generation and polyamine depletion[J].Food Chem Toxicol,2011,49(1):149-154.
[15]Zhu Y,Xie L,Chen G,et al.Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice[J].Pharmazie,2007,62(6):439-444.
[16]Ji Z,Tang Q,Zhang J,et al.Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells[J].Oncol Lett,2011,2(6):1303-1307.
[17]王永强,金黑鹰,李丽梅,等.冬凌草甲素纳米结晶的制备及其体外对结肠癌细胞增殖与凋亡的影响[J].山东医药,2015,55(15):4-7.
[18]Jie D U,Chen C,Sun Y,et al.Ponicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis[J].Mol Med Rep,2015,12(4):5816-5820.
[19]Liu L,Li J,Zeng K W,et al.Five new Biphenanthrenes from Cremastra appendiculata[J].Molecules,2016,21(8):1089.
[20]Ren Y,Shen L,Zhang D W,et al.Two new sesquiterpenoids from Solanum lyratum with cytotoxic activities[J].Chem Pharm Bull(Tokyo),2009,57(4):408-410.
[21]Mitaine-Offer A C,Marouf A,Hanquet B,et al.Two triterpene saponins from Achyranthes bidentata[J].Chem Pharm Bull(Tokyo),2001,49(11):1492-1494.
[22]Wang K W,Zhu J R,Shen L Q.A new lignan with anti-tumour activity from Polygonum perfoliatum L.[J].Nat Prod Res,2013,27(6):568-573.
[23]赵益,孙有智,陈奇.肿节风注射液体外抗肿瘤作用的实验研究[J].中国民族民间医药,2008,17(2):8-9.
[24]徐一新,项昭保,陈晓晶,等.中药猫人参中的抗肿瘤活性成分[J].第二军医大学学报,2011,32(7):749-753.
[25]于林楠,翟宏颖.山慈菇提取物对结肠癌HT29细胞凋亡的影响[J].中国民族民间医药,2016,25(16):17-19.
[26]陈永杰,史仁杰.藤梨根提取物对大肠癌Lo Vo细胞增殖的抑制作用及诱导凋亡的影响[J].世界华人消化杂志,2012,20(18):1657-1661.
[27]陈永杰,史仁杰.藤梨根提取物对HT-29荷瘤裸鼠的抑制及诱导凋亡作用的影响[J].世界华人消化杂志,2012(17):1547-1552.
[28]万春霞,赵凤达,万福生,等.白英诱导大肠癌HT29细胞凋亡作用及其机制研究[J].江苏中医药,2011,43(10):83-85.
[29]Baskar A A,Al Numair K S,Alsaif M A,et al.In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer[J].Redox Rep,2012,17(4):145-156.
[30]Wu J,Wan Z,Yi J,et al.Investigation of the extracts from Bidens pilosa Linn.var.radiata Sch.Bip.for antioxidant activities and cytotoxicity against human tumor cells[J].J Nat Med,2013,67(1):17-26.
[31]吴建国,吴岩斌,万仲贤,等.白花鬼针草乙酸乙酯部位对RKO细胞线粒体膜电位的影响[J].福建中医药,2015,46(3):50-51.
[32]赵逸斌,邓科,杨少辉,等.龙葵碱体外诱导人结肠癌SW480细胞凋亡及其对相关因子的影响[J].上海中医药杂志,2015,49(12):73-77.
[33]Jie Y,Hai J,Wang C,et al.Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects[J].Biomed Pharmacother,2015,72:125-134.
[34]Kwan H Y,Yang Z,Fong W F,et al.The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells[J].J Gastroenterol,2013,48(2):182-192.
[35]杨鹏高,方勇,郭竹英,等.冬凌草甲素诱导结肠癌细胞凋亡的机制研究[J].肿瘤,2009,29(9):842-846.
[36]胡兵,沈克平,史秀峰,等.藤梨根对RKO结肠癌细胞失巢凋亡的作用[J].中国实验方剂学杂志,2013,19(16):242-245.
[37]胡兵,沈克平,史秀峰,等.蛇莓对人结肠癌RKO细胞失巢凋亡作用的实验研究[J].世界中西医结合杂志,2013,8(1):69-72.
[38]Dong A,Fang Y,Zhang L,et al.Caffeic acid 3,4-dihydroxyphenethyl ester induces cancer cell senescence by suppressing twist expression[J].J Pharmacol Exp Ther,2011,339(1):238-247.
[39]高丰厚,郭竹英,徐芒华,等.冬凌草甲素诱导结直肠癌细胞SW-1116凋亡与衰老的体内外实验研究[J].上海交通大学学报(医学版),2010,30(6):683-688.
[40]胡兵,安红梅,沈克平,等.藤龙补中汤促结肠癌LS-174-T细胞衰老及其机制[J].中西医结合学报,2010,8(11):1048-1052.
[41]胡兵,安红梅,郑佳露,等.藤龙补中汤促人结肠癌RKO细胞衰老及其可能的作用机制[J].肿瘤,2016,36(12):1307-1311.
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