老年急性缺血性卒中患者焦虑抑郁症状与认知功能障碍的相关性
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摘要
目的:研究老年急性缺血性卒中患者焦虑抑郁症状与认知功能障碍的相关性。方法:选取2016年12月-2017年12月本院收治的老年急性缺血性卒中患者200例作为研究对象,根据焦虑抑郁症状分为研究组(焦虑抑郁患者)和对照组(非焦虑抑郁患者)各100例。采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、简易精神状态评价量表(MMSE)及神经功能缺损程度评分量表(NIHSS)进行评分,并进行相关性分析。结果:①研究组患者HAMA评分、HAMD评分均显著高于对照组(t=36.90,47.205;P<0.001);②研究组患者MMSE评分显著低于对照组(t=19.957,P<0.001),NIHSS评分显著高于对照组(t=11.426,P<0.001);③老年急性缺血性卒中患者MMSE评分与HAMA评分、HAMD评分呈负相关(r=-0.533,-0.568;P<0.05),NIHSS评分与HAMA评分、HAMD评分呈正相关(r=0.761,0.724;P<0.05)。结论:老年急性缺血性卒中患者焦虑抑郁症状与认知功能障碍呈显著的相关性,医护人员应对患者给予适当有效的心理干预,降低焦虑、抑郁等不良情绪的发生。
Objective:To investigate the correlation between anxiety and depression and cognitive dysfunction in elderly patients with acute ischemic stroke.Methods:A total of 200 elderly patients with acute ischemic stroke treated in our hospital from December 2016 to December 2017 were selected and divided into two groups according to the presence or absence of anxiety and depressive symptoms,namely,study group(anxious and depressed patients)and control group(non-anxiety and depressed patients).The Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),Mini-mental State Examination(MMSE)and national institutes of Health Stroke Scale(NIHSS)were used to assess the patients,then the correlation of the detected indicators was analyzed.Results:① The HAMA and HAMD scores in the study group were significantly higher than those in the control group(t=36.90,47.205;P<0.001);② The study group had higher NIHSS score and lower MMSE score than that in the control group(t=19.957,11.426;P<0.001);③ The MMSE score was negatively correlated with HAMA score and HAMD score(r=-0.533,-0.568;P<0.05),while NIHSS score was positively correlated with HAMA score and HAMD score(r=0.761,0.724;P<0.05).Conclusion:The cognitive dysfunction in elderly patients with acute ischemic stroke is significantly related with anxiety and depressive symptoms,so the appropriate and effective psychological interventions are necessary for the patients.
Objective:To investigate the correlation between anxiety and depression and cognitive dysfunction in elderly patients with acute ischemic stroke.Methods:A total of 200 elderly patients with acute ischemic stroke treated in our hospital from December 2016 to December 2017 were selected and divided into two groups according to the presence or absence of anxiety and depressive symptoms,namely,study group(anxious and depressed patients)and control group(non-anxiety and depressed patients).The Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),Mini-mental State Examination(MMSE)and national institutes of Health Stroke Scale(NIHSS)were used to assess the patients,then the correlation of the detected indicators was analyzed.Results:① The HAMA and HAMD scores in the study group were significantly higher than those in the control group(t=36.90,47.205;P<0.001);② The study group had higher NIHSS score and lower MMSE score than that in the control group(t=19.957,11.426;P<0.001);③ The MMSE score was negatively correlated with HAMA score and HAMD score(r=-0.533,-0.568;P<0.05),while NIHSS score was positively correlated with HAMA score and HAMD score(r=0.761,0.724;P<0.05).Conclusion:The cognitive dysfunction in elderly patients with acute ischemic stroke is significantly related with anxiety and depressive symptoms,so the appropriate and effective psychological interventions are necessary for the patients.
引文
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[10]汤永健,林燕,区开云,等.血清同型半胱氨酸水平与急性缺血性脑卒中患者颈动脉粥样硬化斑块稳定性及神经功能缺损程度的相关性研究[J].实用心脑肺血管病杂志,2016,24(12):56-57
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[12]刘妍,黄小波,陈文强,等.老年遗忘型轻度认知障碍患者认知功能与抑郁障碍的相关性分析[J].中国医药导报,2018,26(5):843-846
[13]曾令烽,梁伟雄,曹烨,等.不同程度认知障碍与老年患者抑郁症相关性研究[J].中华中医药杂志,2016,31(5):1906-1913
[14]Lapmanee S,Charoenphandhu J,Teerapornpuntakit J,et al.Agomelatine,venlafaxine,and running exercise effectively prevent anxiety-and depression-like behaviors and memory impairment in restraint stressed rats[J].Plos One,2017,12(11):187671
[15]高智玉,杨团峰,朱莎,等.慢性焦虑、抑郁对老年轻型急性缺血性卒中患者伴发认知功能障碍的影响研究[J].中国全科医学,2018,21(7):874-878
[16]曾群娣,江朝能,陈勇瑞.老年急性脑梗死后患者焦虑抑郁与认知功能障碍的关系[J].实用中西医结合临床,2016,16(10):9-11
[2]董芳,杜怡峰.代谢综合征与老年缺血性脑卒中继发血管性认知功能障碍的相关性分析[J].中国现代医学杂志,2017,27(27):71-76
[3]李梦阳,宋颖,赵岳,等.老年慢性病患者抑郁、焦虑障碍认知情况及与身心疾病识别的相关性研究[J].中华现代护理杂志,2016,22(15):2139-2143
[4]罗怡欣,黄燕林,李浩宇,等.老年糖尿病肾病患者营养状况与焦虑、抑郁水平及认知功能的相关性研究[J].中华现代护理杂志,2017,23(10):751-752
[5]宋鸿,王新燕.重复经颅磁刺激配合个性化护理对抑郁症患者负性情绪及生活质量的影响[J].中国健康心理学杂志,2017,25(9):1309-1314
[6]刘永珍,尹静,赵翠竹,等.急性期首发脑卒中后抑郁状态与认知功能障碍的相关危险因素研究[J].中华老年心脑血管病杂志,2018,20(4):628-629
[7]朱英标,官常荣,汤亚男,等.肢体缺血预处理在非心源性缺血性脑卒中患者二级预防中临床应用研究[J].中华全科医学,2016,14(12):2045-2048
[8]陆小青,张仟,孙熠.通络扶正汤治疗缺血性脑卒中临床疗效及对患者血清炎性因子和神经功能缺损程度的影响[J].四川中医,2018,37(1):127-129
[9]杨永翠.综合护理干预对静脉溶栓桥接动脉取栓急性脑梗死患者心理状况及预后的影响[J].中国健康心理学杂志,2018,26(3):752-754
[10]汤永健,林燕,区开云,等.血清同型半胱氨酸水平与急性缺血性脑卒中患者颈动脉粥样硬化斑块稳定性及神经功能缺损程度的相关性研究[J].实用心脑肺血管病杂志,2016,24(12):56-57
[11]Aydin E,Hritcu L,Dogan G,et al.The effects of inhaled pimpinella peregrina,essential oil on scopolamine-induced memory impairment,anxiety,and depression in laboratory rats[J].Molecular Neurobiology,2016,53(9):6557-6567
[12]刘妍,黄小波,陈文强,等.老年遗忘型轻度认知障碍患者认知功能与抑郁障碍的相关性分析[J].中国医药导报,2018,26(5):843-846
[13]曾令烽,梁伟雄,曹烨,等.不同程度认知障碍与老年患者抑郁症相关性研究[J].中华中医药杂志,2016,31(5):1906-1913
[14]Lapmanee S,Charoenphandhu J,Teerapornpuntakit J,et al.Agomelatine,venlafaxine,and running exercise effectively prevent anxiety-and depression-like behaviors and memory impairment in restraint stressed rats[J].Plos One,2017,12(11):187671
[15]高智玉,杨团峰,朱莎,等.慢性焦虑、抑郁对老年轻型急性缺血性卒中患者伴发认知功能障碍的影响研究[J].中国全科医学,2018,21(7):874-878
[16]曾群娣,江朝能,陈勇瑞.老年急性脑梗死后患者焦虑抑郁与认知功能障碍的关系[J].实用中西医结合临床,2016,16(10):9-11