基于数据挖掘探讨黄春林教授治疗痛风的用药规律
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摘要
目的应用中医传承辅助系统软件分析黄春林教授治疗痛风用药规律。方法收集2015年11月~2016年12月广东省中医院黄春林教授门诊就诊的72例痛风患者及中药处方256首,录入"中医传承辅助平台"系统,采用系统中的关联规则、改进互信息法、复杂系统熵聚类等无监督数据挖掘方法,总结黄教授治疗痛风的常用药物,分析方剂中的组方规律。结果对纳入的72例痛风患者,256张处方进行分析,确定处方中药物的使用频次,药物间的关联,挖掘黄春林教授治疗痛风的基本方及"车前草、土茯苓、苍术、黄柏"等8首新处方。结论黄春林教授以清热利湿、化痰通络、补益肝肾为基本治法,选用薏苡仁、黄柏、牛膝、土茯苓、山药、苍术、黄芪、生地黄等辨病辨证相结合,治疗痛风经验丰富,中医传承辅助系统对名老中医经验的传承、临床医师经验的总结和中药新药的发现将起到非常重要的辅助作用。
Objective To analyze medication rule of Professor Huang Chunlin in the treatment of hyperuricemia with traditional Chinese medicine inheritance assistant system software. Methods 72 cases of gout and prescription 256 treated by Professor Huang Chunlin in Guangdong Province Traditional Chinese Medical Hospital during the period from November 2015 to December 2016 were input onto "TCM Inheritance Assistance Platform". The drug used characteristics and prescription-formulating principle of Professor Huang Chunlin in the treatment of gout were summarized by the unsupervised data mining method of association rules, improved mutual information method, complex system entropy clustering. Results A total of 256 prescriptions were analyzed for 72 patients with gout enrolled in the study. The frequency of drug use and the association between drugs were determined. The basic prescriptions and 8 new prescriptions including plantago asiatica, smilax glabra, rhizoma atractylodis, cortex phellodendri and etc. for the treatment of gout of Professor Huang Chunlin were excavate d. Conclusion Clearing away heat and promoting diuresis, eliminating phlegm and freeing channels, tonifying the liver and kidney as the basic treatment, Professor Huang Chunlin selected coix seed, cortex phellodendri, achyranthes bidentata, smilax glabra, rhizoma atractylodis, radix astragali, radix rehmanniae and other Chinese herbs to treat patients with the integration of syndrome identifying and disease diagnosing. The traditional Chinese medicine inheritance assistance system will play a very important auxiliary role in inheriting the experience of famous TCM doctor, summarizing the experience of clinicians and finding new drugs of traditional Chinese medicine.
Objective To analyze medication rule of Professor Huang Chunlin in the treatment of hyperuricemia with traditional Chinese medicine inheritance assistant system software. Methods 72 cases of gout and prescription 256 treated by Professor Huang Chunlin in Guangdong Province Traditional Chinese Medical Hospital during the period from November 2015 to December 2016 were input onto "TCM Inheritance Assistance Platform". The drug used characteristics and prescription-formulating principle of Professor Huang Chunlin in the treatment of gout were summarized by the unsupervised data mining method of association rules, improved mutual information method, complex system entropy clustering. Results A total of 256 prescriptions were analyzed for 72 patients with gout enrolled in the study. The frequency of drug use and the association between drugs were determined. The basic prescriptions and 8 new prescriptions including plantago asiatica, smilax glabra, rhizoma atractylodis, cortex phellodendri and etc. for the treatment of gout of Professor Huang Chunlin were excavate d. Conclusion Clearing away heat and promoting diuresis, eliminating phlegm and freeing channels, tonifying the liver and kidney as the basic treatment, Professor Huang Chunlin selected coix seed, cortex phellodendri, achyranthes bidentata, smilax glabra, rhizoma atractylodis, radix astragali, radix rehmanniae and other Chinese herbs to treat patients with the integration of syndrome identifying and disease diagnosing. The traditional Chinese medicine inheritance assistance system will play a very important auxiliary role in inheriting the experience of famous TCM doctor, summarizing the experience of clinicians and finding new drugs of traditional Chinese medicine.
引文
[1]杨洪军,赵亚丽,唐仕欢,等.基于熵方法分析中风病方剂中药物之间的关联度[J].中国中医基础医学杂志,2005,11(9):706-708.
[2]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术—中医药现代化,2009,11(2):225-228.
[3]黎创,吴一帆.黄春林治疗痛风及痛风经验分析[J].河北中医,2012,34(9):1287-1288.
[4]贾建云,黄传兵,李明,等.中医药治疗痛风用药规律分析[J].四川中医,2016,35(2):216-218.
[5]刘维,刘晴,吴沅皞.中药内服治疗痛风性关节炎规律分析[J].中华中医药杂志,2016,31(12):5178-5181.
[6]吴霜霜,戚益铭,沈敏鹤,等.痛风性关节炎中医证候规律及临床证治用药研究[J].长春中医药大学学报,2015,29(2):307-310.
[7]潘碧琦,潘建科,刘军,等.基于关联规则和复杂系统熵聚类的痛风用药规律研究[J].中华中医药杂志,2014,29(6):2040-2043.
[8]姜超,唐先平.基于中医传承辅助系统分析唐先平主任医师治疗痛风急性关节炎期用药经验[J].中医临床研究,2016,6(35):4-8.
[9]闫海峰,杨凯伦,樊克涛,等.中药治疗痛风相关专利用药规律分析[J].天津中医药,2016,33(10):629-633.
[10]向黎黎,熊辉,陆小龙,等.中药治疗痛风用药规律的文献研究[J].中医正骨,2015,31(2):46-49.
[11]姜兆荣,于静,金明秀.金明秀教授治疗风湿病的用药规律[J].风湿病与关节炎,2015,4(3):34-39.
[12]刘湘玲,韩德军,杨锡燕.当代名老中医治疗急性痛风性关节炎经验用药规律[J].中国实验方剂学杂志,2017,23(2):187-192.
[13]吴彬才,杨柳,王莘智,等.基于数据挖掘的旷惠桃教授治疗痛风用药规律研究[J].湖南中医药大学学报,2017,39(5):556-561.
[14]江勋,胡爱民.痛风病中医证型分布及用药规律分析[J].湖南中医杂志,2017,33(5):141-143.
[15]饶春梅,任婷,成细华,等.中医药治疗急性痛风性关节炎用药规律分析[J].湖南中医药大学学报,2017,39(5):552-555.
[16]黄艳霞.中医治疗痛风性关节炎用药规律分析[J].湖南中医杂志,2014,30(2):111-112.
[17]孙益,贾万贵,李象钧,等.基于数据挖掘技术的中医药治疗痛风临床用药分析研究[J].中国中医急症,2014,23(1):58-64.
[18]周慧敏,向楠,胡旭.运用伏邪学说从肾论治痛风病[J].陕西中医,2016,37(3):332-333.
[19]袁晓静,沈丕安,戴琪萍,等.痛风性关节炎的中医治疗进展[J].现代生物医学进展,2014,14(28):5582-5585.
[20]张志文,蔡雪,李宇丹.中药内外兼治急性痛风性关节炎并痛风临床观察[J].湖南中医药大学学报,2017,37(1):58-61.
[2]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术—中医药现代化,2009,11(2):225-228.
[3]黎创,吴一帆.黄春林治疗痛风及痛风经验分析[J].河北中医,2012,34(9):1287-1288.
[4]贾建云,黄传兵,李明,等.中医药治疗痛风用药规律分析[J].四川中医,2016,35(2):216-218.
[5]刘维,刘晴,吴沅皞.中药内服治疗痛风性关节炎规律分析[J].中华中医药杂志,2016,31(12):5178-5181.
[6]吴霜霜,戚益铭,沈敏鹤,等.痛风性关节炎中医证候规律及临床证治用药研究[J].长春中医药大学学报,2015,29(2):307-310.
[7]潘碧琦,潘建科,刘军,等.基于关联规则和复杂系统熵聚类的痛风用药规律研究[J].中华中医药杂志,2014,29(6):2040-2043.
[8]姜超,唐先平.基于中医传承辅助系统分析唐先平主任医师治疗痛风急性关节炎期用药经验[J].中医临床研究,2016,6(35):4-8.
[9]闫海峰,杨凯伦,樊克涛,等.中药治疗痛风相关专利用药规律分析[J].天津中医药,2016,33(10):629-633.
[10]向黎黎,熊辉,陆小龙,等.中药治疗痛风用药规律的文献研究[J].中医正骨,2015,31(2):46-49.
[11]姜兆荣,于静,金明秀.金明秀教授治疗风湿病的用药规律[J].风湿病与关节炎,2015,4(3):34-39.
[12]刘湘玲,韩德军,杨锡燕.当代名老中医治疗急性痛风性关节炎经验用药规律[J].中国实验方剂学杂志,2017,23(2):187-192.
[13]吴彬才,杨柳,王莘智,等.基于数据挖掘的旷惠桃教授治疗痛风用药规律研究[J].湖南中医药大学学报,2017,39(5):556-561.
[14]江勋,胡爱民.痛风病中医证型分布及用药规律分析[J].湖南中医杂志,2017,33(5):141-143.
[15]饶春梅,任婷,成细华,等.中医药治疗急性痛风性关节炎用药规律分析[J].湖南中医药大学学报,2017,39(5):552-555.
[16]黄艳霞.中医治疗痛风性关节炎用药规律分析[J].湖南中医杂志,2014,30(2):111-112.
[17]孙益,贾万贵,李象钧,等.基于数据挖掘技术的中医药治疗痛风临床用药分析研究[J].中国中医急症,2014,23(1):58-64.
[18]周慧敏,向楠,胡旭.运用伏邪学说从肾论治痛风病[J].陕西中医,2016,37(3):332-333.
[19]袁晓静,沈丕安,戴琪萍,等.痛风性关节炎的中医治疗进展[J].现代生物医学进展,2014,14(28):5582-5585.
[20]张志文,蔡雪,李宇丹.中药内外兼治急性痛风性关节炎并痛风临床观察[J].湖南中医药大学学报,2017,37(1):58-61.