基于关联规律探析中医药治疗儿童反复呼吸道感染的用药规律与特点
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摘要
目的:应用中医传承辅助平台(TCMISS)软件分析儿童反复呼吸道感染的中药处方用药规律。方法:通过中国知网、重庆维普以及万方数据库收集近5年治疗儿童反复呼吸道感染文献中的中药处方,分析处方中各种中药的使用频次、药物之间的关联规则及核心药物组合。结果:对筛选出的110个中药处方和197味中药进行分析,确定处方中药物的使用频次,四气五味,归经,药物之间的关联规则,挖掘出10个核心组合。结论:治疗儿童反复呼吸道感染常用的中药以补气药和祛风解表药为主,其药物归经主要集中在脾、肺、胃经,而四气五味以性温、平、热,味辛、苦、甘为主,这些药物多具有健脾益气、祛风解表、补气固表、健脾益肺的功效。防风,黄芪,白术,太子参,党参,甘草,陈皮,茯苓是临床治疗儿童反复呼吸道感染常用的核心药物。
Objective: To analyze medication rules of herbal prescriptions for children suffering recurrent respiratory tract infection(RRTI) using Traditional Chinese Medicine Inheritance Support System(TCMISS).Methods: Herbal prescriptions for children with RRTI in the recent five years were collected from CNKI, VIP and WanFang, to analyze the frequency of different herbs, association rules between herbs and core herb combinations in modern prescriptions. Results: All 110 herbal prescriptions and 197 herbs which were screened were analyzed to ensure the frequency, four natures and five flavors of the herbs in the prescriptions and association rules between herbs, ten core combinations were mined. Conclusion: The herbs which were commonly used to treat RRTI are the ones of tonifying Qi, dispelling wind and relieving exterior mainly, the channel tropism of the herbs mainly focus on spleen, lung and stomach, while four natures and five flavors are the natures of warm, mild and hot, the flavors of pungent, bitter and sweet mainly, and these herbs could invigorate spleen and tonify Qi, dispel wind and relieve the exterior, tonify Qi and strengthen the exterior, invigorate spleen and nourish the lung. Fangfeng [Saposhnikovia divaricata(Trucz.) Schischk.], Huangqi[Astragalus membranaceus(Fisch.) Bunge.], Baizhu(Atractylodes macrocephala Koidz.), Taizishen(radix pseudostel ariae), Dangshen [Codonopsis pilosula(Franch.) Nannf.], Gancao(Glycyrrhiza uralensis Fisch.), Chenpi(Orange peel), Fuling(Wolfiporia cocos) are the core herbs which are commonly used in clinic to treat RRTI.
Objective: To analyze medication rules of herbal prescriptions for children suffering recurrent respiratory tract infection(RRTI) using Traditional Chinese Medicine Inheritance Support System(TCMISS).Methods: Herbal prescriptions for children with RRTI in the recent five years were collected from CNKI, VIP and WanFang, to analyze the frequency of different herbs, association rules between herbs and core herb combinations in modern prescriptions. Results: All 110 herbal prescriptions and 197 herbs which were screened were analyzed to ensure the frequency, four natures and five flavors of the herbs in the prescriptions and association rules between herbs, ten core combinations were mined. Conclusion: The herbs which were commonly used to treat RRTI are the ones of tonifying Qi, dispelling wind and relieving exterior mainly, the channel tropism of the herbs mainly focus on spleen, lung and stomach, while four natures and five flavors are the natures of warm, mild and hot, the flavors of pungent, bitter and sweet mainly, and these herbs could invigorate spleen and tonify Qi, dispel wind and relieve the exterior, tonify Qi and strengthen the exterior, invigorate spleen and nourish the lung. Fangfeng [Saposhnikovia divaricata(Trucz.) Schischk.], Huangqi[Astragalus membranaceus(Fisch.) Bunge.], Baizhu(Atractylodes macrocephala Koidz.), Taizishen(radix pseudostel ariae), Dangshen [Codonopsis pilosula(Franch.) Nannf.], Gancao(Glycyrrhiza uralensis Fisch.), Chenpi(Orange peel), Fuling(Wolfiporia cocos) are the core herbs which are commonly used in clinic to treat RRTI.
引文
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[16]杨岩,王力宁,陈炜.王力宁教授从脾胃论治小儿反复呼吸道感染的用药经验[J].中国中西医结合儿科学,2010,2(6):486-488.
[17]丁惠玲,车大钿.“宝根1号”方治疗肺脾两虚型小儿反复呼吸道感染60例临床观察[J].上海中医药杂志,2015,17(9):43-45.
[18]陈元野,韩春明.补脾益肺法提高小儿免疫力改善反复呼吸道感染临床研究[J].辽宁中医药大学学报,2015,17(12):162-164.
[19]孔凡玉.补脾益肺法治疗小儿反复呼吸道感染80例[J].陕西中医,2013,34(10):1348-1349.
[20]邱志文.益气健脾法治疗小儿反复呼吸道感染65例临床观察[J].湖南中医杂志,2014,30(9):69-71.
[2]阙平,牛阳.小儿反复呼吸道感染中医临床研究进展[J].宁夏医科大学学报,2016,38(3):351-355.
[3]李静,魏兴家.羧甲淀粉钠治疗儿童反复呼吸道感染的临床分析[J].中国医院药学杂志,2012,32(3):213-215.
[4]胡晓丽,曹利.当归六黄汤治疗小儿反复呼吸道感染瘀热内结证的临床疗效分析[J].医药前沿,2016,6(9):355-356.
[5]中华中医药学会儿科分会临床评价学组.小儿反复呼吸道感染中药新药临床试验设计与评价技术指南[J].药物评价研究,2015,38(3):238-243.
[6]顾晓东.小儿反复呼吸道感染的病因病机认识及治疗研究[J].北方药学,2014,11(9):95.
[7]李海娇.浅谈用中医辨证治疗小儿反复呼吸道感染的疗效[J].健康导报:医学版,2015,20(10):229.
[8]潘建科,陈海云,刘军,等.中药防治髋部骨折深静脉血栓形成的用药规律研究[J].中医药导报,2017,23(8):58-61.
[9]潘碧琦,潘建科,刘军,等.基于关联规则和复杂系统熵聚类的痛风用药规律研究[J].中华中医药杂志,2014,29(6):2040-2043.
[10]李雪梅,任继欣,王旭东.中西医结合治疗小儿反复呼吸道感染疗效观察[J].陕西中医,2013,34(4):393-394.
[11]邓滪.中西医结合治疗小儿反复呼吸道感染60例临床观察[J].中国民族民间医药,2015,24(9):91-92.
[12]朱光荣.中药联合治疗小儿反复发作型急性上呼吸道感染的临床研究[J].临床医药文献电子杂志,2015,2(22):4579-4580.
[13]马春霞.中医治疗小儿反复呼吸道感染的效果观察[J].中国处方药,2016,14(7):80-81.
[14]黄先柳.中医中药佐治小儿反复呼吸道感染46例临床观察[J].中国保健营养:上旬刊,2013,23(5):2711.
[15]王有成,张立娟,胡国华,等.双补九味汤对小儿反复呼吸道感染的临床疗效及免疫调节的研究[J].中国中药杂志,2012,37(7):1039-1042.
[16]杨岩,王力宁,陈炜.王力宁教授从脾胃论治小儿反复呼吸道感染的用药经验[J].中国中西医结合儿科学,2010,2(6):486-488.
[17]丁惠玲,车大钿.“宝根1号”方治疗肺脾两虚型小儿反复呼吸道感染60例临床观察[J].上海中医药杂志,2015,17(9):43-45.
[18]陈元野,韩春明.补脾益肺法提高小儿免疫力改善反复呼吸道感染临床研究[J].辽宁中医药大学学报,2015,17(12):162-164.
[19]孔凡玉.补脾益肺法治疗小儿反复呼吸道感染80例[J].陕西中医,2013,34(10):1348-1349.
[20]邱志文.益气健脾法治疗小儿反复呼吸道感染65例临床观察[J].湖南中医杂志,2014,30(9):69-71.