参附注射液治疗心脑血管疾病相关物质基础及作用机制研究进展
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摘要
参附注射液(Shenfu injection,SFI)的主要有效成分为人参皂苷和乌头类生物碱,具有回阳救逆、益气固脱之功效,广泛用于心脑血管疾病的治疗。慢性炎症是心脑血管疾病发生的关键因素。SFI作为治疗心脑血管疾病的常用中药制剂,具有改善脏器灌注、保护心肌和脑缺血时组织损伤、改善血流动力学、舒张血管等作用,而且具有确切的抗炎效应。该文基于抗炎角度,对SFI治疗心脑血管疾病相关物质基础及作用机制进行综述,可为SFI的临床应用提供参考。
The main effective components of Shenfu Injection(SFI) are ginsenosides and aconitum alkaloids,which can be used to restore yang to save from collapse and tonify qi in clinic. In recent years,SFI has been widely used in the treatment of cardiovascular and cerebrovascular diseases. Studies have shown that chronic inflammation is a key factor in the occurrence of cardiovascular and cerebrovascular diseases. As a commonly used preparation for clinical cardiovascular and cerebrovascular diseases,SFI not only has the effect of improving organ perfusion,tissue injury, hemodynamics and vasodilation during myocardial and cerebral ischemia, but also has the proved antiinflammatory effect. In this paper,the material foundation and mechanism of SFI in the treatment of cardiovascular and cerebrovascular diseases based on anti-inflammation effect were summarized,providing theoretical reference for the clinical application of SFI in the treatment of cardiovascular and cerebrovascular diseases.
The main effective components of Shenfu Injection(SFI) are ginsenosides and aconitum alkaloids,which can be used to restore yang to save from collapse and tonify qi in clinic. In recent years,SFI has been widely used in the treatment of cardiovascular and cerebrovascular diseases. Studies have shown that chronic inflammation is a key factor in the occurrence of cardiovascular and cerebrovascular diseases. As a commonly used preparation for clinical cardiovascular and cerebrovascular diseases,SFI not only has the effect of improving organ perfusion,tissue injury, hemodynamics and vasodilation during myocardial and cerebral ischemia, but also has the proved antiinflammatory effect. In this paper,the material foundation and mechanism of SFI in the treatment of cardiovascular and cerebrovascular diseases based on anti-inflammation effect were summarized,providing theoretical reference for the clinical application of SFI in the treatment of cardiovascular and cerebrovascular diseases.
引文
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[2]DANESH J,WHINCUP P,WALKER M,et al.Low grade inflammation and coronary heart disease:prospective study and updated meta-analyses[J].BMJ,2000,321:199-204.
[3]ROST N S,WOLF P A,KASE C S,et al.Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack[J].Stroke,2001,32(11):2575-2579.
[4]DEBOER M D.Obesity,systemic inflammation,and increased risk for cardiovascular disease and diabetes among adolescents:a need for screening tools to target interventions[J].Nutrition,2013,29(2):379-386.
[5]蔡红,张慧明.参附注射液临床应用与不良反应研究[J].医学信息,2015,28(13):288.
[6]朱金墙,梁钰彬,华声瑜,等.参附注射液的成分及其对心血管系统的药理作用研究进展[J].中成药,2014,36(4):819-823.
[7]WANG Y Y,LI Y Y,LI L,et al.Protective effects of Shenfu Injection against myocardial ischemia-reperfusion injury via activation of eNOS in rats[J].Biol Pharm Bull,2018,41(9):1406-1413.
[8]GU W,LI C,YIN W,et al.Shen-fu injection reduces postresuscitation myocardial dysfunction in a porcine model of cardiac arrest by modulating apoptosis[J].Shock,2012,38(3):301.
[9]李均梅,于文涛,张文天,等.参附注射液治疗心脑血管疾病的临床应用进展[J].医学综述,2013,19(15):2808-2810.
[10]JIN Y Y,GAO H,ZHANG X Y.Shenfu Injection inhibits inflammation in patients with acute myocardial infarction complicated by cardiac shock[J].Chinese Journal of Integrative Medicine,2017,23(3):170-175.
[11]胡于健.参附注射液对大鼠心肺复苏后早期全身炎症反应的影响[J].心脑血管病防治,2007,7(4):234-235.
[12]吴红金,段姝伟.参附注射液治疗冠心病心力衰竭的临床研究[J].中西医结合心脑血管病杂志,2009,7(5):505-507.
[13]熊艳玲,陈雨,徐国良,等.参附注射液抗休克的物质基础及作用机制研究进展[J].世界科学技术中医药现代化,2018,20(2):294-297.
[14]张娜.参附注射液的化学物质基础和芪参颗粒体内成分研究[D].北京:北京中医药大学,2016.
[15]孙德旭,萧洪文.人参皂苷对脑缺血保护作用的研究进展[J].四川解剖学杂志,2005,12(1):26-28.
[16]FENG R Q,LIU J,WANG Z H,et al.The structure-activity relationship of ginsenosides on hypoxia-reoxygenation induced apoptosis of cardiomyocytes[J].Biochemical and biophysical research communications,2017,494(3-4):556-568.
[17]杨逸,杨丽瑛,戴景峰,等.人参皂苷Rg1药理活性的研究进展[J].时珍国医国药,2012,23(12):3121-3123.
[18]李成鹏,张梦思,刘俊,等.人参皂苷Rg_1延缓脑衰老机制研究[J].中国中药杂志,2014,39(22):4442-4447.
[19]孙宪昌,陈文芳.人参皂苷RG1对IGF-IR和GR诱导的炎症性多巴胺能神经元变性的影响[C]//中国生理学会第24届全国会员代表大会暨生理学学术大会论文集,2014.
[20]贺欣,张英杰.人参皂苷Rg1通过NF-κB通路减轻大鼠心肌缺血再灌注损伤[J].中药药理与临床,2015,31(4):16-19.
[21]胡婷婷.人参皂苷Re对心肌缺血再灌注损伤中炎症反应及PGI_2/TXA_2系统的影响[D].长春:吉林大学,2010.
[22]陈荻,李阳,田梦,等.人参皂苷Re对慢性酒精中毒大鼠学习、记忆能力的影响及机制[J].中华中医药学刊,2016,34(12):2974-2977.
[23]唐敏敏.人参皂苷Rb1的抗抑郁作用及其神经免疫机制的研究[D].成都:电子科技大学,2017.
[24]宋志明,余舒杰,巩贵宏,等.人参皂苷Rb1通过抑制炎症反应及氧化应激改善老年小鼠内皮功能[J].中国实验诊断学,2018,22(6):1066-1070.
[25]WANG L,ZHANG Y,WANG Z,et al.Inhibitory effect of ginsenoside-Rd on carrageenan-induced inflammation in rats[J].Canadian Journal of Physiology and Pharmacology,2012,90(2):229-236.
[26]SHI M,LIU X.Ginsenoside-RD is efficacious against acute ischemic stroke by suppressing microglial proteasome-mediated inflammation[J].Journal of cerebral blood flow and metabolism,2016,36(1):804.
[27]ZHANG G,XIA F,ZHANG Y,et al.Ginsenoside Rd is efficacious against acute ischemic stroke by suppressing microglial proteasome-mediated inflammation[J].Molecular Neurobiology,2016,53(4):2529-2540.
[28]NESTEROVA I V,POVETEVA T N,AKSINENKO S G,et al.Evaluation of anti-inflammatory activity of extracts from Siberian plants[J].Vestn Ross Akad Med Nauk,2009,11:30-34.
[29]SON K H,KANG S S,SHIM S H,et al.A new diterpenoid alkaloid from aconitum jaluense[J].Journal of Asian Natural Products Research,2006,8(5):451-455.
[30]KANG S S,SHIM S H,SON K H,et al.Alkaloids from the roots of aconitum pseudo-laeve var.erectum[J].Journal of Natural Products,2006,69(3):400-402.
[31]张盼盼,张俊贞,王朝虹,等.参附注射液中3种痕量成分乌头碱、次乌头碱、新乌头碱的测定[J].中国中药杂志,2013,38(10):1521-1525.
[32]YANG H,LIU L,GAO H,et al.Direct and comprehensive analysis of ginsenosides and diterpene alkaloids in Shenfu injection by combinatory liquid chromatography-mass spectrometric techniques[J].Journal of Pharmaceutical and Biomedical Analysis,2014,92:13-21.
[33]艾嫦,朱妍妍,赵长琦.乌头属植物化学成分、药理作用及其内生菌的研究进展[J].天然产物研究与开发,2012,24(2):248-259.
[34]王筠默.中国红参与高丽红参的比较研究[J].中医药学刊,2003,21(2):178-180.
[35]崔云秀.红参中L-丙氨酸单糖苷(ADF)的合成及抗糖尿病药理活性研究[D].长春:吉林农业大学,2012.
[36]刘瑶,张娜,史社坡,等.亲水作用色谱-质谱联用法同时测定参附注射液中的14种有机酸[J].中国中药杂志,2016,41(18):3342-3348.
[37]ZHANG B J,WANG Y L,WANG C Y,et al.Effect of Shenfu injection on nuclear factor-kappaB during myocardial ischemia/reperfusion injury in rats[J].Chinese Journal of Traumatology,2005,8(4):200-204.
[38]史觐诚.人参皂苷Rd抑制大鼠溃疡性结肠炎急性阶段结肠组织内NF-κB信号转导系统激活[D].兰州:兰州大学,2011.
[39]姜文大,粱灵君,顾洁莹,等.人参皂苷Rg1对腹主动脉缩窄致大鼠心肌肥厚和TLR4的影响[J].中药药理与临床,2013,29(1):35-38.
[40]LI X,JIANG J,SHI S,et al.A RG-II type polysaccharide purified from aconitum coreanum alleviates lipopolysaccharideinduced inflammation by inhibiting the NF-κB signal pathway[J].Plos One,2014,9(6):e99697.
[41]WANG M,CHEN Y,XIONG Z,et al.Ginsenoside Rb1 inhibits free fatty acids-induced oxidative stress and inflammation in 3T3-L1 adipocytes[J].Molecular Medicine Reports,2017,16(6):9165-9172.
[42]高先琦.人参皂苷Rg1通过G蛋白耦联雌激素受体抑制BV2小胶质细胞炎症反应的实验研究[D].青岛:青岛大学,2015.
[43]孙宪昌.人参皂苷Rg1通过抑制炎症反应保护黑质多巴胺能神经元的实验研究[D].青岛:青岛大学,2016.
[44]曹姗姗.人参皂苷Re对心肌缺血大鼠的保护作用及其机制的研究[D].长春:吉林大学,2010.
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