摘要
树状大分子自组装为构建新型纳米递送系统提供了新的策略;近年来,我们通过肽类树状大分子自组装成功构建了一系列生物启发型纳米材料。本研究旨在利用肽类树状大分子具有聚电解质的特性,构建一类具有p H响应性的树状大分子组装体,以实现在肿瘤细胞微环境的弱酸条件下触发纳米系统崩解,进而实现负载药物分子的快速释放,达到定点靶向释放的目的。与此同时,树状大分子组装体在结构与功能上具有仿病毒的显著特征,本研究同时关注这种仿病毒的纳米结构能否提高肿瘤富集与渗透的效应,将药物携带至肿瘤组织深处,实现高效的传递效果,提高抗肿瘤药物治疗效率,同时减少毒副作用。
Supramolecular dendritic systems emerge as a promising new-generation bioinspired nanoplatform for nanomedicine. Herein, we report capsid-like mimics self-assembled from peptide dendrimers and functionalized peptides to enhance drug penetration and site-specific delivery for tumor therapy. These drug-loaded supramolecular dendritic systems are endowed with capsid-like component and nanostructure by a facile supramolecular approach. As expected, the drug-loaded capsid-like nanocarriers show some desirable advantages for antitumor drug delivery: a) well-defined nanostructure to improve drug location at tumor site, b) capsid-like architecture to enhance drug penetration, c) high internalization, p H-controlled release and nuclear delivery to jointly achieve site-specific delivery. Based on these merits, the drugloaded capsid nanocarriers provide efficient tumor suppression to 4T1 tumor bearing BALB/c mice and decrease the DOX-induced toxicity during treatment course.
引文
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