解淀粉芽胞杆菌胞外抑菌活性物质研究现状
|
摘要
解淀粉芽胞杆菌是芽胞杆菌属的一个种,在生长过程中可以向胞外分泌多种抑菌活性物质。按照胞外抑菌活性物质合成方式的不同分为两大类,一类是通过核糖体途径合成的核糖体类细菌素、几丁质酶和β-1,3-葡聚糖酶等抑菌物质;另一类是通过非核糖体途径合成的细菌素、表面活性素、芬荠素、伊枯草菌素等脂肽类物质。这些代谢产物种类丰富、广谱抑菌、抗逆性强,可应用于农业、食品工业和环境保护等。本文对解淀粉芽胞杆菌抑菌活性物质的研究及应用现状进行综述,为深入研究和全面开发解淀粉芽胞杆菌抑菌活性物质提供充足的理论依据。
Bacillus amyloliquefaciens belongs to Bacillus species,which can produce a variety of antibacterial active compounds.There are two categories of compounds based on the way of synthesis,one including ribosomal bacteriocins,chitinases,β-1,3-glucanases and other antibacterial substances synthesized through ribosome pathway,while the other including lipopeptides synthesized through non-ribosome pathway,such as bacteriocins,surfactin,fengycins and iturins.These metabolites are of broad antibacterial spectrum with high stress resistance,which can be widely used in agricultural production,food industry and environmental protection.Here,the antibacterial activity of B.amyloliquefaciens and its application were reviewed to provide theoretical basis for deeply research and advanced development of new antibacterial substances from the bacteria.
Bacillus amyloliquefaciens belongs to Bacillus species,which can produce a variety of antibacterial active compounds.There are two categories of compounds based on the way of synthesis,one including ribosomal bacteriocins,chitinases,β-1,3-glucanases and other antibacterial substances synthesized through ribosome pathway,while the other including lipopeptides synthesized through non-ribosome pathway,such as bacteriocins,surfactin,fengycins and iturins.These metabolites are of broad antibacterial spectrum with high stress resistance,which can be widely used in agricultural production,food industry and environmental protection.Here,the antibacterial activity of B.amyloliquefaciens and its application were reviewed to provide theoretical basis for deeply research and advanced development of new antibacterial substances from the bacteria.
引文
[1]Schofield BJ,Skarshewski A,Lachner N,et al.Near complete genome sequence of the animal feed probiotic,Bacillus amyloliquefaciens H57[J].Stand Genomic Sci,2016,11(1):60.
[2]Liu W,Wang X,Wu L,et al.Isolation,identification and characterization of Bacillus amyloliquefaciens BZ-6,a bacterial isolate for enhancing oil recovery from oily sludge[J].Chemosphere,2012,87(10):1105-1110.
[3]Sutyak KE,Wirawan RE,Aroutcheva AA,et al.Isolation of the Bacillus subtilis antimicrobial peptide subtilosin from the dairy product-derived Bacillus amyloliquefaciens[J].J Appl Microbiol,2008,104(4):1067-1074.
[4]Odak A,Zielińska D.Bacteriocins from lactic acid bacteria as an alternative to antibiotics[J].Postepy Hig Med Dosw,2017,71(0):328-338.
[5]WANG Shiqiong.Study on feeding effects of Bacillus amyloliquefaciens on broilers[D].Zhengzhou:He′nan Agricultural University,2015.(in Chinese)王世琼.解淀粉芽孢杆菌对肉仔鸡饲喂效果的研究[D].郑州:河南农业大学,2015.
[6]St9ver AG,Driks A.Regulation of synthesis of the Bacillus subtilis transition-phase,spore-associated antibacterial protein TasA[J].J Bacteriol,1999,181(17):5476-5481.
[7]YAO Wulan,WANG Yunshan,HAN Jigang,et al.Purification and cloning of an antifungal protein from the rice diseases controlling bacterial strain Paenibacillus polymyxa WY110[J].Acta Genet Sinic,2004,31(9):878-887.(in Chinese)姚乌兰,王云山,韩继刚,等.水稻生防菌株多粘类芽孢杆菌WY110抗菌蛋白的纯化及其基因克隆[J].遗传学报,2004,31(9):878-887.
[8]LIU Qiao,QUAN Chunshan,FAN Shengdi.Extraction of antimicrobial substances from fermentation of Bacillus amyloliquefaciens Q-12by ultra filtration[J].Food Sci Technol,2006(7):70-72.(in Chinese)刘俏,权春善,范圣第.超滤解淀粉芽孢杆菌发酵液提取抗菌物质的研究[J].食品科技,2006(7):70-72.
[9]Martin DF,Priest FG,Todd C,et al.Distribution of beta-glconases within the genus Bacillus[J].Appl Envion Microbiol,1980,40(6):1136-1138.
[10]WANG Yimin.Cloning of chitinase gene andβ-1,3-glucanase gene and expression in Bacillus subtilis B-908[D].Beijing:China Agricultural University,1997.(in Chinese)王益民.几丁质酶基因和β-1,3-葡聚糖酶基因的克隆及双价基因在枯草芽胞杆菌B-908中的表达[D].北京:中国农业大学,1997.
[11]Walsh CT.Polyketide and nonribosomal peptide antibiotics:Modularity and versatility[J].Science,2004,303(5665):1805-1810.
[12]Koglin A,L9hr F,Bernhard F,et al.Structural basis for the selectivity of the external thioesterase of the surfactin synthetase[J].Nature,2008,454(7206):907-911.
[13]Angelini TE,Roper M,Kolter R,et al.Bacillus subtilis spreads by surfing on waves of surfactant[J].Proc Natl Acad Sci U S A,2009,106(43):18109-18113.
[14]Wiehitra L,Punpen H,Samerchai C.Growth inhibitory properties of Bacillus subtilis strains and their metabolites against the green mold pathogen(Penicillium digitatum Sacc.)of citrus fruit[J].Postharvest Biol Technol,2008,48(1):113-121.
[15]Gao Z,Zhao X,Yang T,et al.Immunomodulation therapy of diabetes by oral administration of a surfactin lipopeptide in NOD mice[J].Vaccine,2014,32(50):6812-6819.
[16]ZHANG Rongsheng,WANG Xiaoyu,LUO Chuping,et al.Identification of the lipopeptides from Bacillus amyloliquefaciens Lx-11and biocontrol efficacy of surfactin against bacterial leaf streak[J].Sci Agri Sinic,2013,46(10):2014-2021.(in Chinese)张荣胜,王晓宇,罗楚平,等.解淀粉芽孢杆菌Lx-11产脂肽类物质鉴定及表面活性素对水稻细菌性条斑病的防治作用[J].中国农业科学,2013,46(10):2014-2021.
[17]GONG Gudi,ZHOU Guangtian,GUO Yang,et al.Study and prospects for properties and identification of lipopeptide surfactin,iturin and fengycin[J].China Food Addit,2013(3):211-215.(in Chinese)龚谷迪,周广田,郭阳,等.脂肽surfactin、iturin、fengycin性质鉴定的研究与展望[J].中国食品添加剂,2013(3):211-215.
[18]Thimon L,Peypoux F,Wallach J,et al.Effect of the lipopeptide antibiotic,iturin A,on morphology and membrane ultrastructure of yeast cells[J].FEMS Microbiol Lett,1995,128(2):101-106.
[19]Moyne AL,Cleveland TE,Tuzun S.Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D[J].FEMS Microbiol Lett,2004,234(1):43-49.
[20]Arrebola E,Jacobs R,Korsten L.Iturin A is the principal inhibitor in the biocontrol activity of Bacillus amyloliquefaciens PPCB004against postharvest fungal pathogens[J].J Appl Microbiol,2010,108(2):386-395.
[21]Vanittanakom N,Loeffler W,Koch U,et al.Fengycin-a novel antifungal lipopeptide antibiotic produced by Baeillus subrilis F-29-3[J].J Antibiot,1986(Tokyo),39(7):888-901.
[22]DONG Weixin,LI Baoqing,LI Shezeng,et al.The fengycin lipopeptides are major components in the Bacillus subtilis strain NCD-2against the growth of Botrytis cinerea[J].Acta Phytopathol Sinic,2013,43(4):401-410.(in Chinese)董伟欣,李宝庆,李社增,等.脂肽类抗生素fengycin在枯草芽胞杆菌NCD-2菌株抑制番茄灰霉病菌中的功能分析[J].植物病理学报,2013,43(4):401-410.
[23]Arguelles-Arias A,Ongena M,Halimi B,et al.Bacillus amyloliquefaciens GA1as a source of potent antibiotics and other secondary metabolites for biocontrol of plant pathogens[J].Microb Cell Fact,2009,8:63.
[24]Li W,Tang XX,Yan X,et al.A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5[J].Nat Prod Res,2016:1-6.
[25]Chen XH,Scholz R,Borriss M,et al.Difficidin and bacilysin produced by plant-associated Bacillus amyloliquefaciens are efficient in controlling fire blight disease[J].J Biotechnol,2009,140(1/2):38-44.
[26]Fiddaman PJ,Rossall S.Effect of substrate on the production of antifungal volatiles fromBacillus subtilis[J].J Appl Bacteriol,1994,76(4):395-405.
[27]CAO Jingjing.Control effect and mechanism of Bacillus amyloliquefaciens on wheat yellow mosaic disease[D].Yangling:Northwest A&F University,2015.(in Chinese)曹晶晶.解淀粉芽孢杆菌对小麦黄花叶病的生物防治研究[D].杨凌:西北农林科技大学,2015.
[28]YANG Hongfeng,YU Xiangyang,XUE Yarong,et al.Colonization of endophytic Bacillus amyloliquefaciens CC09in wheat roots observed under transmission electron microscopy and its biocontrol efficiency against diseases[J].Chin J Biol Control,2014,30(6):839-844.(in Chinese)杨洪凤,余向阳,薛雅蓉,等.内生解淀粉芽孢杆菌CC09在小麦根部定殖的电镜观察及防病效果[J].中国生物防治学报,2014,30(6):839-844.
[29]SHEN Lili,WANG Fenglong,QIAN Yumei,et al.Tobacco growth-promotion effect and TMV resistance of Bacillus amyloliquefaciens Ba33[J].J Jilin Agr Univ,2010,32(4):383-386.(in Chinese)申莉莉,王凤龙,钱玉梅,等.解淀粉芽孢杆菌Ba33对烟草的促生及抗TMV作用[J].吉林农业大学学报,2010,32(4):383-386.
[30]ZHAO Jiangtao,ZHAO Yancun,HUANG Kaihong,et al.Screening of antagonistic strain and its biocontrol ability against postharvest soft rot of taro caused by Erwinia carotovora subsp.carotovora[J].Food Sci,2014,35(7):155-159.(in Chinese)赵江涛,赵延存,黄开红,等.芋头软腐病拮抗菌的筛选及生防效果研究[J].食品科学,2014,35(7):155-159.
[31]唐小波,杨晓尧,潘康成.产植酸酶芽孢杆菌的筛选及对肉鸡生长性能的影响[J].中国畜牧杂志,2013,49(1):60-64.
[32]SHEN Yongtao.The effect of Bacillus on Microflora of sows and piglets and optimization of its growth conditions[D].Wuhan:Huazhong Agricultural University,2011.(in Chinese)沈勇涛.芽孢杆菌对母猪仔猪微生态的影响及其生长条件优化[D].武汉:华中农业大学,2011.
[33]JI Jian.Study on the mechanism of Bacillus amyloliquefaciens SC06mediating gut immunity in pigs[D].Hangzhou:Zhejiang University,2013.(in Chinese)计坚.解淀粉芽孢杆菌SC06介导猪肠道免疫机理的研究[D].杭州:浙江大学,2013.
[34]SHI Wei,XIE Weitian,ZHANG Yan,et al.Preliminary research on effect of fermentation broth of Bacillus amyloliquifaciens on fresh-keeping of chilled meat[J].China Brew,2011(10):51-54.(in Chinese)时威,谢为天,张岩,等.解淀粉芽孢杆菌发酵液保鲜冷却猪肉的效果研究[J].中国酿造,2011(10):51-54.
[35]Kaewklom S,Lumlert S,Kraikul W,et al.Control of Listeria monocytogenes on sliced bologna sausage using a novel bacteriocin,amysin,produced by Bacillus amyloliquefaciens isolated from Thai shrimp paste(Kapi)[J].Food Control,2013,32(2):552-557.
[36]LI Chao,WU Weizhong,WU Weilong,et al.Ability of Bacillus amyloliquefaciens to inhibit growth of Anabaena flosaquae and the inhibition mechanism[J].Acta Sci Circumstantiae,2011,31(8):1602-1608.(in Chinese)李超,吴为中,吴伟龙,等.解淀粉芽孢杆菌对鱼腥藻的抑藻效果分析与机理初探[J].环境科学学报,2011,31(8):1602-1608.
[37]Maget-Dana R,Ptak M,Peypoux F,et al.Pore-forming properties of iturin A,a lipopeptide antibiotic[J].Biochim Biophys Acta,1985,815(3):405-409.
[38]Bonmatin JM,Laprévote O,Peypoux F.Diversity among microbial cyclic lipopeptides:Iturins and surfactins.Activitystructure relationships to design new bioactive agents[J].Comb Chem High Throughput Screen,2003,6(6):541-556.
[39]Yin H,Guo C,Wang Y,et al.Fengycin inhibits the growth of the human lung cancer cell line 95Dthrough reactive oxygen species production and mitochondria-dependent apoptosis[J].Anticancer Drugs,2013,24(6):587-598.
[40]Cheng W,Feng YQ,Ren J,et al.Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29cell line[J].Neoplasma,2016,63(2):215-222.
[41]Zhao P,Quan C,Wang Y,et al.Bacillus amyloliquefaciens Q-426as a potential biocontrol agent against Fusarium oxysporumf.sp.spinaciae[J].J Basic Microbiol,2014,54(5):448-456.
[42]Goussous SA,Casford MTL,Murphy AC,et al.Structure of the fundamental lipopeptide surfactin at the air/water interface investigated by sum frequency generation spectroscopy[J].JPhys Chem B,2017,121(19),5072-5077.
[43]Kwon GH,Park JY,Kim JS,et al.Cloning and expression of abpr gene encoding bacillopeptidase F fromBacillus amyloliquefaciens CH86-1[J].J Microbiol Biotechnol,2011,21(5):515-518.
[2]Liu W,Wang X,Wu L,et al.Isolation,identification and characterization of Bacillus amyloliquefaciens BZ-6,a bacterial isolate for enhancing oil recovery from oily sludge[J].Chemosphere,2012,87(10):1105-1110.
[3]Sutyak KE,Wirawan RE,Aroutcheva AA,et al.Isolation of the Bacillus subtilis antimicrobial peptide subtilosin from the dairy product-derived Bacillus amyloliquefaciens[J].J Appl Microbiol,2008,104(4):1067-1074.
[4]Odak A,Zielińska D.Bacteriocins from lactic acid bacteria as an alternative to antibiotics[J].Postepy Hig Med Dosw,2017,71(0):328-338.
[5]WANG Shiqiong.Study on feeding effects of Bacillus amyloliquefaciens on broilers[D].Zhengzhou:He′nan Agricultural University,2015.(in Chinese)王世琼.解淀粉芽孢杆菌对肉仔鸡饲喂效果的研究[D].郑州:河南农业大学,2015.
[6]St9ver AG,Driks A.Regulation of synthesis of the Bacillus subtilis transition-phase,spore-associated antibacterial protein TasA[J].J Bacteriol,1999,181(17):5476-5481.
[7]YAO Wulan,WANG Yunshan,HAN Jigang,et al.Purification and cloning of an antifungal protein from the rice diseases controlling bacterial strain Paenibacillus polymyxa WY110[J].Acta Genet Sinic,2004,31(9):878-887.(in Chinese)姚乌兰,王云山,韩继刚,等.水稻生防菌株多粘类芽孢杆菌WY110抗菌蛋白的纯化及其基因克隆[J].遗传学报,2004,31(9):878-887.
[8]LIU Qiao,QUAN Chunshan,FAN Shengdi.Extraction of antimicrobial substances from fermentation of Bacillus amyloliquefaciens Q-12by ultra filtration[J].Food Sci Technol,2006(7):70-72.(in Chinese)刘俏,权春善,范圣第.超滤解淀粉芽孢杆菌发酵液提取抗菌物质的研究[J].食品科技,2006(7):70-72.
[9]Martin DF,Priest FG,Todd C,et al.Distribution of beta-glconases within the genus Bacillus[J].Appl Envion Microbiol,1980,40(6):1136-1138.
[10]WANG Yimin.Cloning of chitinase gene andβ-1,3-glucanase gene and expression in Bacillus subtilis B-908[D].Beijing:China Agricultural University,1997.(in Chinese)王益民.几丁质酶基因和β-1,3-葡聚糖酶基因的克隆及双价基因在枯草芽胞杆菌B-908中的表达[D].北京:中国农业大学,1997.
[11]Walsh CT.Polyketide and nonribosomal peptide antibiotics:Modularity and versatility[J].Science,2004,303(5665):1805-1810.
[12]Koglin A,L9hr F,Bernhard F,et al.Structural basis for the selectivity of the external thioesterase of the surfactin synthetase[J].Nature,2008,454(7206):907-911.
[13]Angelini TE,Roper M,Kolter R,et al.Bacillus subtilis spreads by surfing on waves of surfactant[J].Proc Natl Acad Sci U S A,2009,106(43):18109-18113.
[14]Wiehitra L,Punpen H,Samerchai C.Growth inhibitory properties of Bacillus subtilis strains and their metabolites against the green mold pathogen(Penicillium digitatum Sacc.)of citrus fruit[J].Postharvest Biol Technol,2008,48(1):113-121.
[15]Gao Z,Zhao X,Yang T,et al.Immunomodulation therapy of diabetes by oral administration of a surfactin lipopeptide in NOD mice[J].Vaccine,2014,32(50):6812-6819.
[16]ZHANG Rongsheng,WANG Xiaoyu,LUO Chuping,et al.Identification of the lipopeptides from Bacillus amyloliquefaciens Lx-11and biocontrol efficacy of surfactin against bacterial leaf streak[J].Sci Agri Sinic,2013,46(10):2014-2021.(in Chinese)张荣胜,王晓宇,罗楚平,等.解淀粉芽孢杆菌Lx-11产脂肽类物质鉴定及表面活性素对水稻细菌性条斑病的防治作用[J].中国农业科学,2013,46(10):2014-2021.
[17]GONG Gudi,ZHOU Guangtian,GUO Yang,et al.Study and prospects for properties and identification of lipopeptide surfactin,iturin and fengycin[J].China Food Addit,2013(3):211-215.(in Chinese)龚谷迪,周广田,郭阳,等.脂肽surfactin、iturin、fengycin性质鉴定的研究与展望[J].中国食品添加剂,2013(3):211-215.
[18]Thimon L,Peypoux F,Wallach J,et al.Effect of the lipopeptide antibiotic,iturin A,on morphology and membrane ultrastructure of yeast cells[J].FEMS Microbiol Lett,1995,128(2):101-106.
[19]Moyne AL,Cleveland TE,Tuzun S.Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D[J].FEMS Microbiol Lett,2004,234(1):43-49.
[20]Arrebola E,Jacobs R,Korsten L.Iturin A is the principal inhibitor in the biocontrol activity of Bacillus amyloliquefaciens PPCB004against postharvest fungal pathogens[J].J Appl Microbiol,2010,108(2):386-395.
[21]Vanittanakom N,Loeffler W,Koch U,et al.Fengycin-a novel antifungal lipopeptide antibiotic produced by Baeillus subrilis F-29-3[J].J Antibiot,1986(Tokyo),39(7):888-901.
[22]DONG Weixin,LI Baoqing,LI Shezeng,et al.The fengycin lipopeptides are major components in the Bacillus subtilis strain NCD-2against the growth of Botrytis cinerea[J].Acta Phytopathol Sinic,2013,43(4):401-410.(in Chinese)董伟欣,李宝庆,李社增,等.脂肽类抗生素fengycin在枯草芽胞杆菌NCD-2菌株抑制番茄灰霉病菌中的功能分析[J].植物病理学报,2013,43(4):401-410.
[23]Arguelles-Arias A,Ongena M,Halimi B,et al.Bacillus amyloliquefaciens GA1as a source of potent antibiotics and other secondary metabolites for biocontrol of plant pathogens[J].Microb Cell Fact,2009,8:63.
[24]Li W,Tang XX,Yan X,et al.A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5[J].Nat Prod Res,2016:1-6.
[25]Chen XH,Scholz R,Borriss M,et al.Difficidin and bacilysin produced by plant-associated Bacillus amyloliquefaciens are efficient in controlling fire blight disease[J].J Biotechnol,2009,140(1/2):38-44.
[26]Fiddaman PJ,Rossall S.Effect of substrate on the production of antifungal volatiles fromBacillus subtilis[J].J Appl Bacteriol,1994,76(4):395-405.
[27]CAO Jingjing.Control effect and mechanism of Bacillus amyloliquefaciens on wheat yellow mosaic disease[D].Yangling:Northwest A&F University,2015.(in Chinese)曹晶晶.解淀粉芽孢杆菌对小麦黄花叶病的生物防治研究[D].杨凌:西北农林科技大学,2015.
[28]YANG Hongfeng,YU Xiangyang,XUE Yarong,et al.Colonization of endophytic Bacillus amyloliquefaciens CC09in wheat roots observed under transmission electron microscopy and its biocontrol efficiency against diseases[J].Chin J Biol Control,2014,30(6):839-844.(in Chinese)杨洪凤,余向阳,薛雅蓉,等.内生解淀粉芽孢杆菌CC09在小麦根部定殖的电镜观察及防病效果[J].中国生物防治学报,2014,30(6):839-844.
[29]SHEN Lili,WANG Fenglong,QIAN Yumei,et al.Tobacco growth-promotion effect and TMV resistance of Bacillus amyloliquefaciens Ba33[J].J Jilin Agr Univ,2010,32(4):383-386.(in Chinese)申莉莉,王凤龙,钱玉梅,等.解淀粉芽孢杆菌Ba33对烟草的促生及抗TMV作用[J].吉林农业大学学报,2010,32(4):383-386.
[30]ZHAO Jiangtao,ZHAO Yancun,HUANG Kaihong,et al.Screening of antagonistic strain and its biocontrol ability against postharvest soft rot of taro caused by Erwinia carotovora subsp.carotovora[J].Food Sci,2014,35(7):155-159.(in Chinese)赵江涛,赵延存,黄开红,等.芋头软腐病拮抗菌的筛选及生防效果研究[J].食品科学,2014,35(7):155-159.
[31]唐小波,杨晓尧,潘康成.产植酸酶芽孢杆菌的筛选及对肉鸡生长性能的影响[J].中国畜牧杂志,2013,49(1):60-64.
[32]SHEN Yongtao.The effect of Bacillus on Microflora of sows and piglets and optimization of its growth conditions[D].Wuhan:Huazhong Agricultural University,2011.(in Chinese)沈勇涛.芽孢杆菌对母猪仔猪微生态的影响及其生长条件优化[D].武汉:华中农业大学,2011.
[33]JI Jian.Study on the mechanism of Bacillus amyloliquefaciens SC06mediating gut immunity in pigs[D].Hangzhou:Zhejiang University,2013.(in Chinese)计坚.解淀粉芽孢杆菌SC06介导猪肠道免疫机理的研究[D].杭州:浙江大学,2013.
[34]SHI Wei,XIE Weitian,ZHANG Yan,et al.Preliminary research on effect of fermentation broth of Bacillus amyloliquifaciens on fresh-keeping of chilled meat[J].China Brew,2011(10):51-54.(in Chinese)时威,谢为天,张岩,等.解淀粉芽孢杆菌发酵液保鲜冷却猪肉的效果研究[J].中国酿造,2011(10):51-54.
[35]Kaewklom S,Lumlert S,Kraikul W,et al.Control of Listeria monocytogenes on sliced bologna sausage using a novel bacteriocin,amysin,produced by Bacillus amyloliquefaciens isolated from Thai shrimp paste(Kapi)[J].Food Control,2013,32(2):552-557.
[36]LI Chao,WU Weizhong,WU Weilong,et al.Ability of Bacillus amyloliquefaciens to inhibit growth of Anabaena flosaquae and the inhibition mechanism[J].Acta Sci Circumstantiae,2011,31(8):1602-1608.(in Chinese)李超,吴为中,吴伟龙,等.解淀粉芽孢杆菌对鱼腥藻的抑藻效果分析与机理初探[J].环境科学学报,2011,31(8):1602-1608.
[37]Maget-Dana R,Ptak M,Peypoux F,et al.Pore-forming properties of iturin A,a lipopeptide antibiotic[J].Biochim Biophys Acta,1985,815(3):405-409.
[38]Bonmatin JM,Laprévote O,Peypoux F.Diversity among microbial cyclic lipopeptides:Iturins and surfactins.Activitystructure relationships to design new bioactive agents[J].Comb Chem High Throughput Screen,2003,6(6):541-556.
[39]Yin H,Guo C,Wang Y,et al.Fengycin inhibits the growth of the human lung cancer cell line 95Dthrough reactive oxygen species production and mitochondria-dependent apoptosis[J].Anticancer Drugs,2013,24(6):587-598.
[40]Cheng W,Feng YQ,Ren J,et al.Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29cell line[J].Neoplasma,2016,63(2):215-222.
[41]Zhao P,Quan C,Wang Y,et al.Bacillus amyloliquefaciens Q-426as a potential biocontrol agent against Fusarium oxysporumf.sp.spinaciae[J].J Basic Microbiol,2014,54(5):448-456.
[42]Goussous SA,Casford MTL,Murphy AC,et al.Structure of the fundamental lipopeptide surfactin at the air/water interface investigated by sum frequency generation spectroscopy[J].JPhys Chem B,2017,121(19),5072-5077.
[43]Kwon GH,Park JY,Kim JS,et al.Cloning and expression of abpr gene encoding bacillopeptidase F fromBacillus amyloliquefaciens CH86-1[J].J Microbiol Biotechnol,2011,21(5):515-518.