中国胃癌患者癌组织中IGF-1表达与临床病理参数关联性的Meta分析
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摘要
目的:采用Meta分析探讨中国胃癌患者胃癌组织中胰岛素样生长因子1 (IGF-1)表达与胃癌患者临床病理参数之间的关系,为胃癌的诊断及治疗提供循证医学证据。方法:在PubMed、中国知网、维普中文科技期刊数据库、万方数据库和中国生物医学文献数据库对胃癌患者IGF-1阳性表达率与胃癌患者临床病理参数关系的文献进行全面检索。采用Review Manager 5.2软件对符合纳入标准的文献资料进行Meta分析。结果:最终进入本研究的文献11篇,其中胃癌组993例,非肿瘤胃黏膜组织对照组601例。Meta分析,IGF-1阳性表达率在胃癌组与对照组(OR=9.05,95%CI:6.82～12.01)、胃癌低分化组与中和高分化组(OR=1.53,95%CI:1.14～2.06)、累及全层组与未累及全层组(OR=0.16,95%CI:0.09～0.28)、淋巴结转移组与非淋巴结转移组(OR=0.12,95%CI:0.08～0.17)以及TNM分期Ⅲ-Ⅳ期组与TNM分期Ⅰ-Ⅱ期组(OR=0.21,95%CI:0.13～0.33)之间比较差异均有统计学意义(P<0.01)。结论:在中国胃癌患者胃癌组织中IGF-1高表达与肿瘤的发生、发展、浸润和转移有密切关联,其异常表达可作为胃黏膜细胞癌变的危险因素,是胃癌早期诊断和治疗有价值的分子生物学检测指标。
Objective:To investigate the relationships between the expression of insulin-like growth factor-1(IGF-1)in the gastric cancer tissue and the clinicopathological parameters in the gastric cancer patients in China with Meta-analysis,and to provide the evidence-based medical evidence for the diagnosis and treatment of gastric cancer.Methods:The literatures about the relationships between the positive expression rate of IGF-1 and the clinicopathological paramters in the gastric cancer patients were searched comprehensively in PubMed,China National Knowledge Infrastructure,Weipu Chinese Science and Technology Journal Database,Wanfang Database and China Biomedical Literature Database.Review Manager 5.2 software was used to conduct Meta analysis on the literatures that met the inclusion criteria.Results:There were 11 articles in the literatures were selected,including993 cases in gastric cancer group and 601 cases in non-tumor gastric mucosal tissue control group.Meta-analysis showed the significant differences in the positive expression rates of IGF-1 between gastric cancer group and control group(OR=9.05,95% CI:6.82-12.01),poorly differentiated gastric cancer group and moderately-highly differentiated group(OR=1.53,95% CI:1.14-2.06),involving full-thickness group and unaffected fullthickness group(OR=0.16,95% CI:0.09-0.28),lymph node metastasis group and non-lymph node metastasis group(OR=0.12,95% CI:0.08-0.17),TNM stageⅢ-Ⅳ group and TNM stageⅠ-Ⅱ group(OR=0.21,95% CI:0.13-0.33).Conclusion:The high expression of IGF-1 in gastric cancer tissue is closely related to the occurrence,development,invasion and metastasis of tumor in the gastric cancer patients in China.The abnormal expression of IGF-1 could be used as a risk factor for carcinogenesis of gastric mucosal cells and a valuable molecular biological marker for early diagnosis and treatment of gastric cancer.
Objective:To investigate the relationships between the expression of insulin-like growth factor-1(IGF-1)in the gastric cancer tissue and the clinicopathological parameters in the gastric cancer patients in China with Meta-analysis,and to provide the evidence-based medical evidence for the diagnosis and treatment of gastric cancer.Methods:The literatures about the relationships between the positive expression rate of IGF-1 and the clinicopathological paramters in the gastric cancer patients were searched comprehensively in PubMed,China National Knowledge Infrastructure,Weipu Chinese Science and Technology Journal Database,Wanfang Database and China Biomedical Literature Database.Review Manager 5.2 software was used to conduct Meta analysis on the literatures that met the inclusion criteria.Results:There were 11 articles in the literatures were selected,including993 cases in gastric cancer group and 601 cases in non-tumor gastric mucosal tissue control group.Meta-analysis showed the significant differences in the positive expression rates of IGF-1 between gastric cancer group and control group(OR=9.05,95% CI:6.82-12.01),poorly differentiated gastric cancer group and moderately-highly differentiated group(OR=1.53,95% CI:1.14-2.06),involving full-thickness group and unaffected fullthickness group(OR=0.16,95% CI:0.09-0.28),lymph node metastasis group and non-lymph node metastasis group(OR=0.12,95% CI:0.08-0.17),TNM stageⅢ-Ⅳ group and TNM stageⅠ-Ⅱ group(OR=0.21,95% CI:0.13-0.33).Conclusion:The high expression of IGF-1 in gastric cancer tissue is closely related to the occurrence,development,invasion and metastasis of tumor in the gastric cancer patients in China.The abnormal expression of IGF-1 could be used as a risk factor for carcinogenesis of gastric mucosal cells and a valuable molecular biological marker for early diagnosis and treatment of gastric cancer.
引文
[1]KARIMI P,ISLAMI F,ANANDASABAPATHY S,et al.Gastric cancer:descriptive epidemiology,risk factors,screening,and prevention[J].Cancer Epidemiol Biomarkers Prev,2014,23(5):700-713.
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[3]SCARTOZZI M,MANDOLESI A,GIAMPIERI R,et al.Insulin-like growth factor 1expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan[J].Int J Cancer,2010,127(8):1941-1947.
[4]SU C,WANG W,WANG C.IGF-1-induced MMP-11expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway[J].Oncol Lett,2018,15(5):7000-7006.
[5]GANGULY S,BASU B,SHOME S,et al.Dopamine,by acting through its D2receptor,inhibits insulin-like growth factor-I(IGF-I)-induced gastric cancer cell proliferation via up-regulation of Kruppel-like factor 4through down-regulation of IGF-IR and AKT phosphorylation[J].Am J Pathol,2010,177(6):2701-2707.
[6]ZHAO Q,TRAN H,DIMITROV D S,et al.A dual-specific anti-IGF-1/IGF-2human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma[J].Int J Cancer,2015,137(9):2243-2252.
[7]LICHTENSTEIN M J,MULROW C D,ELWOOD P C.Guidelines for reading case-control studies[J].J Chronic Dis,1987,40(9):893-903.
[8]李冬斌,韩锦胜,王英霞,等.胃癌中IGF-Ⅰ、Ⅱ及IGF-ⅠR的表达与临床病理关系的研究[J].河北医药,2013,35(8):1125-1128.
[9]胡东昊.胰岛素样生长因子-1及其结合蛋白-3在胃癌诊断中的应用[J].中国慢性病预防与控制,2015,23(3):211-213.
[10]张海峰,申兴斌,刘莎莎,等.IGF-1及IGF-1R在胃癌中的表达及意义[J].中国微生态学杂志,2016,28(12):1440-1442.
[11]徐航.Klotho和IGF-1在胃癌中的表达及意义[D].长沙:中南大学,2013.
[12]夏惠丽.IGF-1与bcl-2在胃癌组织中的表达及其相关性[D].郑州:郑州大学,2005.
[13]丁娟娟,王邦茂,方维丽,等.胰岛素样生长因子-Ⅰ及其受体在胃癌的表达和意义[J].胃肠病学和肝病学杂志,2009,18(2):103-105.
[14]宋晓华.IGF-Ⅰ、IGF-Ⅱ在胃癌中的表达及临床意义[J].河北医学,2010,16(6):654-657.
[15]张雪英,吉兆宁.胃癌中IGFBP-2、IGFI、IGFIR的表达及意义[J].皖南医学院学报,2008,27(2):98-101.
[16]曹友红,许春芳,马平,等.胰岛素样生长因子-1及其受体在胃癌中的表达及临床意义[J].世界华人消化杂志,2014,22(22):3307-3315.
[17]吴跃文,何杨,吉兆宁,等.胃癌中胰岛素样生长因子结合蛋白-2,胰岛素样生长因子-1和增殖细胞核抗原的表达和临床意义[J].中国临床医学,2008,15(1):70-72.
[18]罗祖炎,李博,徐文娟,等.IGF-1在胃癌组织中的表达及其与浸润转移的关系[J].肿瘤学杂志,2012,18(4):254-258.
[19]DANG X,LI X,WANG L,et al.MicroRNA-3941targets IGF-1to regulate cell proliferation and migration of breast cancer cells[J].Int J Clin Exp Pathol,2017,10(7):7650-7660.
[20]HADDADI N,LIN Y,TRAVIS G,et al.PTEN/PTENP1:‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’,new targets for cancer therapy[J].Mol Cancer,2018,17(1):37.
[21]张海峰,赵杨,刘莎莎,等.IGF-1、IGF-1R及VEGF在胃癌中的表达及其与浸润转移的关系[J].标记免疫分析与临床,2018,25(3):360-364.
[22]刘勇进,俞列群,叶帆.非小细胞肺癌组织中HIF-1α、EGFR、IGF-1的表达及临床意义[J].医学研究杂志,2018,47(5):78-82.
[23]JU J,HAN C,ZAN L,et al.Expression of insulin-like growth factor 1and its receptors in colorectal cancer and their significances[J].Int J Clin Exp Pathol,2017,29(9):593-597.
[24]徐红,郭明华,吕旻彦,等.IGF-1及IGFBP-3在子宫内膜癌组织中的表达及意义[J].实用妇产科杂志,2011,27(12):901-904.
[25]TANG J,JUN-JUN L I,ZHANG Y,et al.Expression and clinical significance of IGF-1and IGF-1Rin epithelial ovarian cancer patients[J].China J Modern Med,2014,24(27):54-58.
[26]WANG H,WANG C,TIAN W,et al.The crucial role of SRPK1in IGF-1-induced EMT of human gastric cancer[J].Oncotarget,2017,8(42):72157-72166.
[27]XU L,ZHOU R,YUAN L,et al.IGF1/IGF1R/STAT3signaling-inducible IFITM2 promotes gastric cancer growth and metastasis[J].Cancer Lett,2017,393:76-85.
[28]ZHANG H F,SHEN X B,LIU S S,et al.Effects of IGF-1down-regulation on proliferation,migration and invasion of human gastric cancer cells[J].Chin J Cancer Prevent Treatment,2017,24(1):16-22.
[2]ALBEROBELLO A T,D’ESPOSITO V,MARASCO D,et al.Selective disruption of insulin-like growth factor-1(IGF-1)signaling via phosphoinositide-dependent kinase-1prevents the protective effect of IGF-1on human cancer cell death[J].J Biol Chem,2010,285(9):6563-6572.
[3]SCARTOZZI M,MANDOLESI A,GIAMPIERI R,et al.Insulin-like growth factor 1expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan[J].Int J Cancer,2010,127(8):1941-1947.
[4]SU C,WANG W,WANG C.IGF-1-induced MMP-11expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway[J].Oncol Lett,2018,15(5):7000-7006.
[5]GANGULY S,BASU B,SHOME S,et al.Dopamine,by acting through its D2receptor,inhibits insulin-like growth factor-I(IGF-I)-induced gastric cancer cell proliferation via up-regulation of Kruppel-like factor 4through down-regulation of IGF-IR and AKT phosphorylation[J].Am J Pathol,2010,177(6):2701-2707.
[6]ZHAO Q,TRAN H,DIMITROV D S,et al.A dual-specific anti-IGF-1/IGF-2human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma[J].Int J Cancer,2015,137(9):2243-2252.
[7]LICHTENSTEIN M J,MULROW C D,ELWOOD P C.Guidelines for reading case-control studies[J].J Chronic Dis,1987,40(9):893-903.
[8]李冬斌,韩锦胜,王英霞,等.胃癌中IGF-Ⅰ、Ⅱ及IGF-ⅠR的表达与临床病理关系的研究[J].河北医药,2013,35(8):1125-1128.
[9]胡东昊.胰岛素样生长因子-1及其结合蛋白-3在胃癌诊断中的应用[J].中国慢性病预防与控制,2015,23(3):211-213.
[10]张海峰,申兴斌,刘莎莎,等.IGF-1及IGF-1R在胃癌中的表达及意义[J].中国微生态学杂志,2016,28(12):1440-1442.
[11]徐航.Klotho和IGF-1在胃癌中的表达及意义[D].长沙:中南大学,2013.
[12]夏惠丽.IGF-1与bcl-2在胃癌组织中的表达及其相关性[D].郑州:郑州大学,2005.
[13]丁娟娟,王邦茂,方维丽,等.胰岛素样生长因子-Ⅰ及其受体在胃癌的表达和意义[J].胃肠病学和肝病学杂志,2009,18(2):103-105.
[14]宋晓华.IGF-Ⅰ、IGF-Ⅱ在胃癌中的表达及临床意义[J].河北医学,2010,16(6):654-657.
[15]张雪英,吉兆宁.胃癌中IGFBP-2、IGFI、IGFIR的表达及意义[J].皖南医学院学报,2008,27(2):98-101.
[16]曹友红,许春芳,马平,等.胰岛素样生长因子-1及其受体在胃癌中的表达及临床意义[J].世界华人消化杂志,2014,22(22):3307-3315.
[17]吴跃文,何杨,吉兆宁,等.胃癌中胰岛素样生长因子结合蛋白-2,胰岛素样生长因子-1和增殖细胞核抗原的表达和临床意义[J].中国临床医学,2008,15(1):70-72.
[18]罗祖炎,李博,徐文娟,等.IGF-1在胃癌组织中的表达及其与浸润转移的关系[J].肿瘤学杂志,2012,18(4):254-258.
[19]DANG X,LI X,WANG L,et al.MicroRNA-3941targets IGF-1to regulate cell proliferation and migration of breast cancer cells[J].Int J Clin Exp Pathol,2017,10(7):7650-7660.
[20]HADDADI N,LIN Y,TRAVIS G,et al.PTEN/PTENP1:‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’,new targets for cancer therapy[J].Mol Cancer,2018,17(1):37.
[21]张海峰,赵杨,刘莎莎,等.IGF-1、IGF-1R及VEGF在胃癌中的表达及其与浸润转移的关系[J].标记免疫分析与临床,2018,25(3):360-364.
[22]刘勇进,俞列群,叶帆.非小细胞肺癌组织中HIF-1α、EGFR、IGF-1的表达及临床意义[J].医学研究杂志,2018,47(5):78-82.
[23]JU J,HAN C,ZAN L,et al.Expression of insulin-like growth factor 1and its receptors in colorectal cancer and their significances[J].Int J Clin Exp Pathol,2017,29(9):593-597.
[24]徐红,郭明华,吕旻彦,等.IGF-1及IGFBP-3在子宫内膜癌组织中的表达及意义[J].实用妇产科杂志,2011,27(12):901-904.
[25]TANG J,JUN-JUN L I,ZHANG Y,et al.Expression and clinical significance of IGF-1and IGF-1Rin epithelial ovarian cancer patients[J].China J Modern Med,2014,24(27):54-58.
[26]WANG H,WANG C,TIAN W,et al.The crucial role of SRPK1in IGF-1-induced EMT of human gastric cancer[J].Oncotarget,2017,8(42):72157-72166.
[27]XU L,ZHOU R,YUAN L,et al.IGF1/IGF1R/STAT3signaling-inducible IFITM2 promotes gastric cancer growth and metastasis[J].Cancer Lett,2017,393:76-85.
[28]ZHANG H F,SHEN X B,LIU S S,et al.Effects of IGF-1down-regulation on proliferation,migration and invasion of human gastric cancer cells[J].Chin J Cancer Prevent Treatment,2017,24(1):16-22.