视网膜中央静脉阻塞与阻塞性睡眠呼吸暂停综合征的相关性
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  • 英文篇名:Relationship between central retinal vein occlusion and obstructive sleep apnea syndrome
  • 作者:陈莲 ; 王延辉 ; 杨帆 ; 何珂 ; 李晓清 ; 姜钊 ; ; 张鹏
  • 英文作者:CHEN Lian;WANG Yan-Hui;YANG Fan;HE Ke;LI Xiao-Qing;JIANG Zhao;LI Lu-Xi;ZHANG Peng;Department of Ophthalmology,Xi'an No.3 Hospital,the Affiliated Hospital of Northwest University;Department of Otorhino-laryngology,Xi'an No.3 Hospital,the Affiliated Hospital of Northwest University;
  • 关键词:视网膜中央静脉阻塞 ; 检查 ; 睡眠呼吸暂停综合征
  • 英文关键词:central retinal vein occlusion;;examination;;obstructive sleep apnea
  • 中文刊名:XKJZ
  • 英文刊名:Recent Advances in Ophthalmology
  • 机构:西安市第三医院眼科,西北大学附属医院眼科;西安市第三医院耳鼻喉科,西北大学附属医院耳鼻喉科;
  • 出版日期:2019-02-18 14:17
  • 出版单位:眼科新进展
  • 年:2019
  • 期:v.39;No.272
  • 语种:中文;
  • 页:XKJZ201902022
  • 页数:4
  • CN:02
  • ISSN:41-1105/R
  • 分类号:89-92
摘要
目的探讨视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)与阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)的相关性。方法选择CRVO组患者及非CRVO患者(对照组)各24例进行研究。采用多导睡眠呼吸记录仪在夜间对CRVO患者及对照组的呼吸暂停低通气指数(apnea-hypopnea index,AHI)、夜间平均最小氧饱和度等指标进行监测。根据AHI对OSAS进行诊断。对两组的OSAS发生率、AHI、夜间平均最小氧饱和度、年龄、体质量指数(body mass index,BMI)等进行比较。结果氉CRVO组BMI(25. 49±4. 17) kg·m~(-2)和AHI(18. 89±14. 54)与对照组[BMI:(22. 57±5. 25) kg·m~(-2)、AHI:8. 25±6. 98]相比均明显升高,而CRVO组夜间平均最小氧饱和度(80. 04±11. 63)%与对照组(89. 14±7. 22)%相比明显降低,差异均有统计学意义(均为P <0. 05)。其中,CRVO组OSAS患病率为75. 00%,显著高于对照组(37. 50%),差异有统计学意义(P <0. 05)。OSAS组[年龄(59. 67±9. 32)岁、BMI(27. 59±5. 19) kg·m~(-2)和AHI (21. 16±12. 08)]与非OSAS组[年龄(53. 31±7. 04)岁、BMI(22. 15±4. 94) kg·m~(-2)、AHI(3. 76±1. 13)]相比均明显升高,而患者夜间平均最小氧饱和度(81. 42±6. 61)%与非OSAS组(87. 08±5. 77)%相比明显降低,差异均有统计学意义(均为P <0. 05)。13例非缺血型CRVO患者中有OSAS 11例(84. 62%),11例缺血型CRVO患者中有OSAS 7例(63. 64%),OSAS在非缺血型及缺血型CRVO患者中的患病率差异无统计学意义(P> 0. 05)。结论 CRVO患者中OSAS的患病率较高,提示OSAS在CRVO的发病进程中起重要作用或者是CRVO发病的使动因素。
        Objective To determine the relationship between central retinal vein occlusion(CRVO) and obstructive sleep apnea syndrome (OSAS). Methods The participants of this retrospective study included 24 consecutive patients with CRVO and 24 ageand sex-matched controls. All participants underwent full-night respiratory polysomnography for monitoring apnea-bypopnea index (AHI),minimal oxygen saturation and body mass index(BMI). Statistical comparisons were performed between the incidence of OSAS, mean AHI, minimum oxygen saturation,age,BMI in both groups. Results When compared with that in control group (BMI: 22. 57 ± 5. 25,AHI: 8. 25 ± 6. 98),both the BMI(25.49 ±4. 17) kg·m~(-2) and AHI(18. 89 ± 14. 54) were significantly increased in the CRVO group, while the average minimum oxygen saturation in CRVO group decreased significantly than that in control group(89. 14 ± 7. 22%) (all P <0. 05). The incidence of OSAS in CRVO group was 75.00% which was significantly higher than that in the control group(37. 50%) (P < 0. 05). The age [(59. 67 ±9.32) years old ],BMI(27.59 ±5. 19) kg · m~(-2) and AHI(21. 16 ± 12.08) of OSAS group were significantly higher than those of non-OSAS group [age :(53. 31 ± 7. 04) years,BMI: (22. 15± 4. 94) kg · m~(-2),AHI :3.76±1.13],while the average minimum oxygen saturation(81.42 ±6. 61)% was significantly lower than that of non-OSAS group (87. 08 ±5.11) %. The differences were statistically significant(all P < 0. 05). There were 11 patients of OSAS(84.62%) in 13 patients with non-ischemic CRVO and 7 patients of OSAS(63.64%) in 11 patients with ischemic CRVO and there was no significant difference in the incidence of OSAS between non-ischemic and ischemic CRVO(P > 0. 05). Conlusion The CRVO patients have a high prevalence of OSAS, indicating that OSAS might be an important role or a triggering factor in the pathogenesis of CRVO.
引文
[1]ISHIDA M,ABE S,NAKAGAWA T,HAYASHI A.Short-term results of endovascular surgery with tissue plasminogen activator injection for central retinal vein occlusion[J].Graefes Arch Clin Exp Ophthalmol,2017,255(11):2135-2140.
    [2]MARTIN S A,APPLETON S L,ADAMS R J,TAYLOR A W,VIN-CENT A,BROOK N R,et al.Erectile dysfunction is independently associated with apnea-hypopnea index and oxygen desaturation index in elderly,but not younger,community-dwelling men[J].Sleep Health,2017,3(4):250-256.
    [3]GABRIC K,MATETIC A,VILOVIC M,TICINOVIC KURIR T,RU-SIC D,GALIC T,et al.Health-related quality of life in type 2 diabetes mellitus patients with different risk for obstructive sleep apnea[J].Pat Pref Adher,2018,12:765-773.
    [4]CABRERA M,BENAVIDES A M,HALLAJI N A E,CHUNG S A,SHAPIRO C M,TROPE G E,et al.Risk of obstructive sleep apnea in open-angle glaucoma versus controls using the STOP-Bang questionnaire[J].Can J Ophthalmol,2018,53(1):76-80.
    [5]DURDIK P,SUJANSKA A,SUROVIAKOVA S,EVANGELISTI M,BANOVCIN P,VILLA M P.Sleep Architecture in children with common phenotype of obstructive sleep apnea[J].J Clin Sleep Med,2018,14(1):9-14.
    [6]ZHAO K X,YANG P Z.Ophthalmology[M].8th ed.Beijing:People’s Medical Publishing House,2013:213-215.赵堪兴,杨培增.眼科学[M].第8版.北京:人民卫生出版社,2013:213-215.
    [7]Writing Group of 2010 Chinese Guidelines for the Management of Hypertension.2010 Chinese guidelines for the management of hypertension[J].Chin J Cardiol,2011,39(7):579-616.中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志,2011,39(7):579-616.
    [8]PETERSMANN A,NAUCK M,MLLER-WIELAND D,KERNERW,MLLER UA,LANDGRAF R,et al.Definition,classification and diagnosis of diabetes mellitus[J].Exp Clin Endocrinol Diabetes,2018,126(7):406-410.
    [9]HUANG H M,WANG R W,LI S,MIAO A Q,XU H,TANG Q.Relationship between body mass index and percent body fat in the diagnosis of obesity:based on diagnostic tests[J].Chin J Sports Med,2017,36(3):218-225.黄晖明,王人卫,李森,缪爱琴,许浩,汤强.体重指数与体脂率指标评价肥胖:基于诊断试验的比较研究[J].中国运动医学杂志,2017,36(3):218-225.
    [10]HAYREH S S,KLUGMAN M R,BERI M,KIMURA A E,PODHA-JSKY P.Differentiation of ischemic from non-ischemic central retinal vein occlusion during the early acute phase[J].Graefes Arch Clin Exp Ophthalmol,1990,228(3):201-217.
    [11]HOU X L,WU S G,GUO Y P.Clinical observation of exenatide for treatment of obesity type 2 diabetes mellitus complicated with obstructive sleep apnea hypopnea syndrome[J].J Xinxiang Med Univ,2018,35(1):50-53.侯小丽,吴述光,郭悦鹏.艾塞那肽治疗肥胖2型糖尿病并发阻塞性睡眠呼吸暂停综合征疗效观察[J].新乡医学院学报,2018,35(1):50-53.
    [12]XU J,DING N,ZHANG X,WANG N,SUN B,ZHANG R,et al.Nocturnal blood pressure fluctuation and associated influential factors in severe obstructive sleep apnea patients with hypertension[J].Sleep Breath,2018,22(4):1045-1052.
    [13]FLORAS J S.Sleep apnea and cardiovascular disease:an enigmatic risk factor[J].Circ Res,2018,122(12):1741-1764.
    [14]CHA J,ZEA-HERNANDEZ J A,SIN S,GRAW-PANZER K,SHIFTEH K,ISASI C R,et al.The effects of obstructive sleep apnea syndrome on the dentate gyrus and learning and memory in children[J].J Neurosci,2017,37(16):4280-4288.
    [15]GLUECK C J,PING W,HUTCHINS R,PETERSEN M R,GOLNIKK.Ocular vascular thrombotic events:central retinal vein and central retinal artery occlusions[J].Clin Appl Thromb Hemost,2008,14(3):286-294.
    [16]FRANKLIN K A,LINDBERG E.Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea[J].J Thorac Dis,2015,7(8):1311-1122.
    [17]GLICKSMAN A,HADJIYANNAKIS S,BARROWMAN N,WALKERS,HOEY L,KATZ S L.Body fat distribution ratios and obstructive sleep apnea severity in youth with obesity[J].J Clin Sleep Med,2017,13(4):545-550.
    [18]CROSTA F,DESIDERI G,MARINI C.Obstructive sleep apnea syndrome in Parkinson’s disease and other parkinsonisms[J].Funct Neurol,2017,32(3):137-141.
    [19]O’HALLORAN K D,LEWIS P,MCDONALD F.Sex,stress and sleep apnoea:Decreased susceptibility to upper airway muscle dysfunction following intermittent hypoxia in females[J].Respir Physiol Neurobiol,2017,245(1):76-82.
    [20]THAPA R,BAJIMAYA S,PAUDYAL G,KHANAL S,TAN S,THAPA S S,et al.Prevalence,pattern and risk factors of retinal vein occlusion in an elderly population in Nepal:the Bhaktapur retina study[J].BMC Ophthalmol,2017,17(1):162.
    [21]TINGTING X,DANMING Y,XIN C.Non-surgical treatment of obstructive sleep apnea syndrome[J].Eur Arch Otorhinolaryngol,2018,275(2):335-346.