解毒化痞膏治疗慢性肝病伴胁痛148例临床研究
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摘要
目的:观察解毒化痞膏治疗慢性肝病胁痛的临床疗效。方法:选取200例慢性肝病伴胁痛患者进行临床研究,采用随机数字表法分为治疗组150例和对照组50例。对照组给予肝病内科常规基础治疗,治疗组在对照组基础上加用解毒化痞膏外敷胁肋部疼痛部位,2组均连续治疗1周。采用简化McGill疼痛问卷评估患者胁肋疼痛程度,评估2组治疗效果。结果:共198例患者完成临床观察(治疗组剔除2例)。治疗组临床控制率52.0%,总有效率91.9%;对照组临床控制率12.0%,总有效率48.0%。治疗组临床控制率及总有效率均高于对照组,差异均有统计学意义(P <0.01)。治疗后,2组疼痛积分均较治疗前降低,差异均有统计学意义(P <0.01);治疗组疼痛积分低于对照组,差异有统计学意义(P <0.01)。治疗后,不同性质的胁痛均可得到缓解(P <0.01),以胀痛型胁痛缓解最明显(P <0.01)。结论:解毒化痞膏可明显缓解慢性肝病患者的胁痛症状,尤其对胀痛患者疗效显著,值得临床推广应用。
Objective:To observe the clinical effect of Jiedu Huapi ointment for hypochondriac pain with chronic liver disease. Methods:Selected 200 cases of patients with chronic liver disease accompanied with hypochondriac pain for clinical study,and divided them into the treatment group(150 cases) and the control group(50 cases) randomly according to random number table. The control group was given routine basic treatment in internal medicine for liver disease,and the treatment group was additionally treated with the external application of Jiedu Huapi ointment for pain area in lateral thorax. The treatment for both groups lasted for one week. Evaluated the degree of pain in lateral thorax of patients by applying simplified McGill pain questionnaire,and assessed the treatment outcome in the two groups. Results:The clinical observation was completed in a total of 198 patients(2 cases were excluded from the treatment group). The clinical control rate in the treatment group was 52.0%,and the total effective rate was 91.9%;the clinical control rate in the control group was 12.0%,and the total effective rate was 48.0%. The clinical control rate and total effective rate in the treatment group were higher than those in the control group,differences being significant(P < 0.01). After treatment,the pain scores in the two groups were lower than those before treatment,differences being significant(P < 0.01);the pain score in the treatment group was lower than that in the control group,difference being significant(P < 0.01). After treatment,hypochondriac pain of different types can be relieved in terms of various degrees(P < 0.01). The most obvious hypochondriac pain relief was found in distending pain type(P< 0.01). Conclusion:Jiedu Huapi ointment can significantly alleviate the symptoms of hypochondriac pain in patients with chronic liver disease,especially in patients of distending pain. It is worthy of clinical promotion and application.
Objective:To observe the clinical effect of Jiedu Huapi ointment for hypochondriac pain with chronic liver disease. Methods:Selected 200 cases of patients with chronic liver disease accompanied with hypochondriac pain for clinical study,and divided them into the treatment group(150 cases) and the control group(50 cases) randomly according to random number table. The control group was given routine basic treatment in internal medicine for liver disease,and the treatment group was additionally treated with the external application of Jiedu Huapi ointment for pain area in lateral thorax. The treatment for both groups lasted for one week. Evaluated the degree of pain in lateral thorax of patients by applying simplified McGill pain questionnaire,and assessed the treatment outcome in the two groups. Results:The clinical observation was completed in a total of 198 patients(2 cases were excluded from the treatment group). The clinical control rate in the treatment group was 52.0%,and the total effective rate was 91.9%;the clinical control rate in the control group was 12.0%,and the total effective rate was 48.0%. The clinical control rate and total effective rate in the treatment group were higher than those in the control group,differences being significant(P < 0.01). After treatment,the pain scores in the two groups were lower than those before treatment,differences being significant(P < 0.01);the pain score in the treatment group was lower than that in the control group,difference being significant(P < 0.01). After treatment,hypochondriac pain of different types can be relieved in terms of various degrees(P < 0.01). The most obvious hypochondriac pain relief was found in distending pain type(P< 0.01). Conclusion:Jiedu Huapi ointment can significantly alleviate the symptoms of hypochondriac pain in patients with chronic liver disease,especially in patients of distending pain. It is worthy of clinical promotion and application.
引文
[1]中华医学会传染病与寄生虫病学分会、肝病学分会联合修订.病毒性肝炎防治方案[J].中华传染病杂志,2000,19(1):56-62.
[2]中华中医药学会.ZYYXH/T4~49-2008中医内科常见病诊疗指南中医病证部分[S].北京:中国中医药出版社,2008:89-90.
[3]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:143-151.
[4]邱志济,邱江东,邱江峰.朱良春治疗肝病顽固胁痛的廉验特色发挥-著名老中医学家朱良春教授临床经验(57)[J].辽宁中医杂志,2004,31(11):892-893.
[5]余洁英,刘小斌,刘成丽,等.广州地区名中医慢性肝炎验方统计分析[J].现代医院,2009,9(8):64-65.
[6]陈静,王灵台,赵钢.肝舒贴治疗慢性肝病胁痛的临床研究[J].上海中医药杂志,2004,38(10):6-8.
[7]龚文亮,吴荔,郑其进,等.消痛散穴位敷贴治疗慢性乙型肝炎胁痛的临床研究[J].现代医院,2016,16(1):51-54.
[2]中华中医药学会.ZYYXH/T4~49-2008中医内科常见病诊疗指南中医病证部分[S].北京:中国中医药出版社,2008:89-90.
[3]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:143-151.
[4]邱志济,邱江东,邱江峰.朱良春治疗肝病顽固胁痛的廉验特色发挥-著名老中医学家朱良春教授临床经验(57)[J].辽宁中医杂志,2004,31(11):892-893.
[5]余洁英,刘小斌,刘成丽,等.广州地区名中医慢性肝炎验方统计分析[J].现代医院,2009,9(8):64-65.
[6]陈静,王灵台,赵钢.肝舒贴治疗慢性肝病胁痛的临床研究[J].上海中医药杂志,2004,38(10):6-8.
[7]龚文亮,吴荔,郑其进,等.消痛散穴位敷贴治疗慢性乙型肝炎胁痛的临床研究[J].现代医院,2016,16(1):51-54.