射干抗病毒口服液和射干抗病毒注射液抗炎作用的比较分析
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摘要
目的比较射干抗病毒口服液和射干抗病毒注射液的抗炎作用。方法通过二甲苯致小鼠耳廓肿胀实验观察射干抗病毒口服液及射干抗病毒注射液的抗炎作用。结果口服液的高剂量组与注射液的中、高剂量组都可明显抑制二甲苯所致小鼠耳肿胀度(与空白组比较,P<0.05,其中口服液高剂量组P=0.006、注射液中剂量组P=0.004、注射液高剂量组P=0.010)。但射干抗病毒口服液和射干抗病毒注射液的抗炎作用差异无统计学意义(P>0.05)。结论射干抗病毒口服液及射干抗病毒注射液均具有明显的抗炎作用,且口服液与注射液的抗炎作用差异不明显。
Objective To compare the anti-inflammatory effects between Shegan Antiviral Oral Liquid and Shegan Antiviral Injection.Methods The anti-inflammatory effects of Shegan Antiviral Oral Liquid and Shegan Antiviral Injection were studied in swelling ears of mice induced by xylene.Results High dose of Oral liquid,medium and high doses of Injection could restrain mice swelling ears caused by xylene(compared with the blank group,P<0.05.High dose of Oral liquid:P=0.006,medium doses of Injection:P=0.004,high doses of Injection:P=0.010).However,there was no significant difference between Shegan Antiviral Oral Liquid and Shegan Antiviral Injection in anti-inflammatory test(P>0.05).Conclusion Shegan Antiviral Oral Liquid and Shegan Antiviral Injection have significant anti-inflammatory effects,while with no significant difference between them.
Objective To compare the anti-inflammatory effects between Shegan Antiviral Oral Liquid and Shegan Antiviral Injection.Methods The anti-inflammatory effects of Shegan Antiviral Oral Liquid and Shegan Antiviral Injection were studied in swelling ears of mice induced by xylene.Results High dose of Oral liquid,medium and high doses of Injection could restrain mice swelling ears caused by xylene(compared with the blank group,P<0.05.High dose of Oral liquid:P=0.006,medium doses of Injection:P=0.004,high doses of Injection:P=0.010).However,there was no significant difference between Shegan Antiviral Oral Liquid and Shegan Antiviral Injection in anti-inflammatory test(P>0.05).Conclusion Shegan Antiviral Oral Liquid and Shegan Antiviral Injection have significant anti-inflammatory effects,while with no significant difference between them.
引文
[1] 王喜平,曹俊丽.射干抗病毒注射液致过敏性皮疹1例[J].新医学,2010,41(4):277.
[2] 高继兰,陈述.射干抗病毒注射液引起皮肤过敏1例[J].齐鲁药事,2006,25(8):508-509.
[3] 张瑞瑞,刘艳萍,聂西周,等.射干抗病毒注射液致类过敏反应初步研究[J].世界中医药,2016,11(4):682-685.
[4] 贾佳,廖欣,王兴东,等.射干抗病毒口服液制备工艺的研究[J].中国医药导报,2013,10(7):131-133.
[5] 张文娟,李茂星,张泉龙,等.栀子苷的快速提取分离及其镇痛抗炎作用研究[J].中国实验剂学杂志,2012,18 (21):170-174.
[6] 徐书云.药理实验方法学[M].北京:人民卫生出版社,2008:58.
[7] 邓鸣,张炜宁.异型南五味子总三萜对类风湿关节炎小鼠抗炎镇痛药效学研究[J].安徽医药,2016,20(8):1469-1472.
[8] 尤献民,邹桂欣,王光函,等.均匀设计法研究射干中异黄酮成分联用抗炎效果[J].辽宁中医杂志,2016,43(10):2158-2159.
[9] 白丽红,邹宇.金银花的药理分析与应用[J].中国现代药物应用,2011,5(4):159-160.
[10] 赵丽.板蓝根药理作用、临床应用及不良反应[J].河北中医,2010,32(7):1059-1060.
[11] 杜士明,杜婷,王刚,等.竹叶柴胡与北柴胡解热镇痛作用的比较[J].中国医院药学杂志,2013,33(7):526-529.
[12] 夏正学,夏恒夫,段大航,等.口服射干抗病毒注射液治疗急性上呼吸道感染172例临床观察[J].中国民康医学杂志,2005,17(7):367-368.
[2] 高继兰,陈述.射干抗病毒注射液引起皮肤过敏1例[J].齐鲁药事,2006,25(8):508-509.
[3] 张瑞瑞,刘艳萍,聂西周,等.射干抗病毒注射液致类过敏反应初步研究[J].世界中医药,2016,11(4):682-685.
[4] 贾佳,廖欣,王兴东,等.射干抗病毒口服液制备工艺的研究[J].中国医药导报,2013,10(7):131-133.
[5] 张文娟,李茂星,张泉龙,等.栀子苷的快速提取分离及其镇痛抗炎作用研究[J].中国实验剂学杂志,2012,18 (21):170-174.
[6] 徐书云.药理实验方法学[M].北京:人民卫生出版社,2008:58.
[7] 邓鸣,张炜宁.异型南五味子总三萜对类风湿关节炎小鼠抗炎镇痛药效学研究[J].安徽医药,2016,20(8):1469-1472.
[8] 尤献民,邹桂欣,王光函,等.均匀设计法研究射干中异黄酮成分联用抗炎效果[J].辽宁中医杂志,2016,43(10):2158-2159.
[9] 白丽红,邹宇.金银花的药理分析与应用[J].中国现代药物应用,2011,5(4):159-160.
[10] 赵丽.板蓝根药理作用、临床应用及不良反应[J].河北中医,2010,32(7):1059-1060.
[11] 杜士明,杜婷,王刚,等.竹叶柴胡与北柴胡解热镇痛作用的比较[J].中国医院药学杂志,2013,33(7):526-529.
[12] 夏正学,夏恒夫,段大航,等.口服射干抗病毒注射液治疗急性上呼吸道感染172例临床观察[J].中国民康医学杂志,2005,17(7):367-368.