基于秀丽隐杆线虫的中药抗衰老成分研究进展（英文）
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摘要
衰老是指随着年龄的增加,机体的生理功能和组织结构发生的退行性变化。衰老可诱导一系列老年病,严重影响老年人生活质量,进行抗衰老研究对于改善这种状态十分必要。秀丽隐杆线虫(线虫)是目前国际上公认的抗衰老研究首选模式生物,广泛用于抗衰老药物的筛选和药物抗衰老机制研究。某些中药成分很久以来就用于抗衰老,近几年文献报道亦见增多,本文综述了基于秀丽隐杆线虫的中药抗衰老成分研究进展,以助于研究者寻找更多中药抗衰老活性成分。
Aging is defined as the degenerative changes in the physiological function and organizational structure of the body with the increasing age.Aging can induce a series of geriatric diseases,which will lead to depressed quality of life in the elderly.The research of anti-aging is particularly necessary to improve this situation.Caenorhabditis elegans(C.elegans) is a model organism for anti-aging research,which has been internationally recognized.It is widely used in the screening of anti-aging drugs and the study of anti-senescence mechanism.Some Chinese herbal ingredients have anti-aging effects,which had been documented since ancient times.This article reviewed the latest research progress of the anti-aging ingredients of traditional Chinese medicine based on C.elegans,which will help researchers discover more anti-aging active ingredients of Chinese medicine.
Aging is defined as the degenerative changes in the physiological function and organizational structure of the body with the increasing age.Aging can induce a series of geriatric diseases,which will lead to depressed quality of life in the elderly.The research of anti-aging is particularly necessary to improve this situation.Caenorhabditis elegans(C.elegans) is a model organism for anti-aging research,which has been internationally recognized.It is widely used in the screening of anti-aging drugs and the study of anti-senescence mechanism.Some Chinese herbal ingredients have anti-aging effects,which had been documented since ancient times.This article reviewed the latest research progress of the anti-aging ingredients of traditional Chinese medicine based on C.elegans,which will help researchers discover more anti-aging active ingredients of Chinese medicine.
引文
[1] Zinger A,Cho W C,Ben-Yehuda A.Cancer and aging - the inflammatory connection[J].Aging & Disease,2017,8(5):611-627.
[2] He C,Zhou C,Kennedy B K.The yeast replicative aging model[J].Biochimica et biophysica acta (BBA)-molecular basis of disease,2018,1864(9):2690-2696.
[3] Qian H,Xu X,Niklason L E.Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16[J].Oncotarget,2015,6(22):18790-18799.
[4] Zou Y X,Ruan M H,Luan J,et al.Anti-aging effect of riboflavin via endogenous antioxidant in fruit fly drosophila melanogaster[J].The Journal of Nutrition,Health & Aging,2017,21(3):314-319.
[5] Houcke J V ,Bollaerts I ,Geeraerts E ,et al.Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes[J].Neurobiology of Aging,2017,60:1-10.
[6] Rancán L,Paredes S D,García I,et al.Protective effect of xanthohumol against age-related brain damage[J].The Journal of Nutritional Biochemistry,2017,49:133-140.
[7] Shobin E,Bowley M P,Estrada L I,et al.Microglia activation and phagocytosis:relationship with aging and cognitive impairment in the rhesus monkey[J].Geroscience,2017,39(2):199-220.
[8] Kumar S,Dietrich N,Kornfeld K.Angiotensin converting enzyme (ACE) inhibitor extends Caenorhabditis elegans Life Span[J].Plos Genetics,2016,12(2):1-28.
[9] Bravo F V ,Da Silva J ,Chan R B ,et al.Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model[J].Scientific Reports,2018,8(1):3540-3552.
[10]Kim H,Perentis R J,Caldwell G A,et al.Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C.elegans Parkinson's models[J].Cell Death & Disease,2018,9(5):555 .
[11]Govindan S.Organoruthenium(II) complexes ameliorates oxidative stress and impedes the age associated deterioration in Caenorhabditis elegans through JNK-1/DAF-16 signalling[J].Scientific Reports,2018,8(1):7688-7702.
[12]赵晴,蒋湉湉.秀丽隐杆线虫研究综述[J].安徽农业科学,2010,38(19):10092-10093.
[13]张佳婵,王昌涛,刘瑶,等.沙棘粕醇提取物对秀丽隐杆线虫的抗衰老功效及其机制[J].食品科学,2017,38(23):141-148.
[14]Lee J H,Nam S H,Hwang S B,et al.Functional genomic approaches using the nematode Caenorhabditis elegans as a model system[J].J Biochem Mol Biol,2004,37(1):107-113.
[15]Brenner S.The genetics of Caenorhabditis elegans[J].Genetics,1974,77(1):71-94.
[16]Guarente L,Kenyon C.Genetic pathways that regulate ageing in model organisms[J].Nature,2000,408(6809):255-262.
[17]Hulme S E,Whitesides G M.Chemistry and the worm:Caenorhabditis elegans as a platform for integrating chemical and biological research[J].Cheminform,2011,50(21):4774-4807.
[18]Gruber J,Tang S Y,Halliwell B.Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans[J].Annals of the New York Academy of Sciences,2007,1100(1):530-542.
[19]Silverman G A,Luke C J,Bhatia S R,et al.Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans[J].Pediatric Research,2009,65(1):10-18.
[20]Consortium C E S.Genome sequence of the nematode C.elegans:a platform for investigating biology[J].Science,1998,282(5396):2012-2018.
[21]Honda Y,Tanaka M,Honda S.Trehalose extends longevity in the nematode Caenorhabditis elegans[J].Aging Cell,2010,9(4):558-569.
[22]Chen P,He D,Zhang Y,et al.Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate stress insult during aging[J].Food & Function,2016,7(11):4576-4588.
[23]Liu Y,Sun Y,Huang G.Preparation and antioxidant activities of important traditional plant polysaccharides[J].International Journal of Biological Macromolecules,2018,111:780-786.
[24]李海春.八种石斛多糖抗氧化、抗衰老活性的比较研究[D].华南农业大学,2016.
[25]Zhang Y,Lyu T,Li M,et al.Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans[J].Pharmacognosy Magazine,2015,11(43):449-454.
[26]Zhang Y,Mi D Y,Wang J,et al.Constituent and effects of polysaccharides isolated from Sophoramoorcroftiana seeds on lifespan,reproduction,stress resistance,and antimicrobial capacity in Caenorhabditis elegans[J].Chinese Journal of Natural Medicines,2018,16(4):252-260.
[27]Li Y,Guan S,Liu C,et al.Neuroprotective effects of Coptis chinensis Franch polysaccharide on amyloid-beta (Aβ)-induced toxicity in a transgenic Caenorhabditis elegans,model of Alzheimer's disease (AD)[J].International Journal of Biological Macromolecules,2018,113:991-995.
[28]Chuang M H,Chiou S H,Huang C H,et al.The lifespan-promoting effect of acetic acid and Reishi polysaccharide[J].Bioorganic & Medicinal Chemistry,2009,17(22):7831-7840.
[29]Zhang H,Pan N,Xiong S,et al.Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans[J].Biochemical Journal,2012,441(1):417-424.
[30]赵薪苑,陈婧,方建国,等.中药和天然药物中黄酮抗病毒活性及其机制研究进展[J].医药导报,2018,37(4):410-415.
[31]陈全利,胡莉,魏玮,等.杜仲总黄酮对大鼠神经源性肌萎缩的影响[J].遵义医学院学报,2016,39(6):563-567.
[32]汪巍,李明,艾纯芝,等.天然黄酮类化合物抑制CYP3A4的构效关系研究(英文)[J].遵义医学院学报,2017,40(1):6-16.
[33]凌伟,张伟,许凤清,等.利用秀丽隐杆线虫研究亳菊不同处理方法的生物活性[J].广州化工,2017,45(11):121-122.
[34]Grünz G,Haas K,Soukup S,et al.Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C.elegans[J].Mechanisms of Ageing & Development,2012,133(1):1-10.
[35]蔡外娇,张新民,黄建华,等.淫羊藿总黄酮延缓秀丽隐杆线虫衰老的实验研究[J].中国中西医结合杂志,2008,28(6):522-525.
[36]蔡外娇.淫羊藿总黄酮、淫羊藿苷、淫羊藿次苷Ⅱ延长健康寿限及其作用机制的研究[D].上海:复旦大学,2012.
[37]Dueňas M,Surcolaos F,Gonzálezmanzano S,et al.Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans[J].Pharmacological Research,2013,76(10):41-48.
[38]Pietsch K,Saul N,Menzel R,et al.Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1,daf-2,sek-1 and unc-43[J].Biogerontology,2009,10(5):565-578.
[39]周溦,林敬明,王素丽,等.半枝莲总黄酮对延缓秀丽隐杆线虫和人脐静脉内皮细胞衰老的影响[J].南方医科大学学报,2017,37(6):821-826.
[40]游庭活.桑椹多酚类化合物抗氧化及延缓衰老作用研究[D].广州:广东药学院,2015.
[41]邓冠军.黄连木叶酚类物质的提取鉴定、生物活性及与精油联产的研究[D].合肥:安徽大学,2014.
[42]Zhu G,Yin F,Wang L,et al.Microdevice for the investigation of high-glucose induced lifespan and the protective effect of polydatin in C.elegans[J].Chinese Journal of Chromatography,2016,34(2):140-145.
[43]Wen H,Gao X,Qin J.Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip[J].Science Foundation in China,2015,6(1):35-43.
[44]王婷婷,张玉瑶,王吉锡,等.白藜芦醇对秀丽隐杆线虫寿命的影响及其初步机制研究[J].神经药理学报,2015,5(5):1-6.
[45]Desjardins D,Cacho-Valadez B,Liu J,et al.Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans[J].Aging Cell,2017,16(1):104-112.
[46]Zheng S,Liao S,Zou Y,et al.Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans[J].AGE,2014,36(6):9719.
[47]唐进法,张帆,李宇辉,等.何首乌乙酸乙酯提取物对秀丽线虫的抗衰老作用研究[J].中国药房,2017,28(4):493-496.
[48]薛晓利,张建琴,马雯,等.基于～1H-NMR代谢组学的黄芪甲苷对秀丽隐杆线虫寿命的延长作用研究[J].中草药,2018,49(10):2274-2281.
[49]王丽萍,崔雅欣,徐佳,等.余甘子对秀丽隐杆线虫的抗衰老作用[J].吉林大学学报:理学版,2018,56(3):738-742.
[50]Feng S,Cheng H,Zhou X,et al.Thermal stress resistance and aging effects of Panax notoginseng,polysaccharides on Caenorhabditis elegans[J].International Journal of Biological Macromolecules,2015,81:188-194.
[51]Su S,Wink M.Natural lignans from Arctium lappa,as antiaging agents in Caenorhabditis elegans[J].Phytochemistry,2015,117:340-350.
[52]Lashmanova E,Zemskaya N,Proshkina E,et al.The evaluation of geroprotective effects of selected flavonoids in drosophila melanogaster and Caenorhabditis elegans[J].Frontiers in Pharmacology,2017,8:884.
[53]Wang X,Zhang J,Lu L,et al.The longevity effect of echinacoside in Caenorhabditis elegans mediated through daf-16[J].Bioscience Biotechnology & Biochemistry,2015,79(10):1676-1683.
[54]Pietsch K,Saul N,Chakrabarti S,et al.Hormetins,antioxidants and prooxidants:defining quercetin-,caffeic acid- and rosmarinic acid-mediated life extension in C.elegans[J].Biogerontology,2011,12(4):329-347.
[2] He C,Zhou C,Kennedy B K.The yeast replicative aging model[J].Biochimica et biophysica acta (BBA)-molecular basis of disease,2018,1864(9):2690-2696.
[3] Qian H,Xu X,Niklason L E.Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16[J].Oncotarget,2015,6(22):18790-18799.
[4] Zou Y X,Ruan M H,Luan J,et al.Anti-aging effect of riboflavin via endogenous antioxidant in fruit fly drosophila melanogaster[J].The Journal of Nutrition,Health & Aging,2017,21(3):314-319.
[5] Houcke J V ,Bollaerts I ,Geeraerts E ,et al.Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes[J].Neurobiology of Aging,2017,60:1-10.
[6] Rancán L,Paredes S D,García I,et al.Protective effect of xanthohumol against age-related brain damage[J].The Journal of Nutritional Biochemistry,2017,49:133-140.
[7] Shobin E,Bowley M P,Estrada L I,et al.Microglia activation and phagocytosis:relationship with aging and cognitive impairment in the rhesus monkey[J].Geroscience,2017,39(2):199-220.
[8] Kumar S,Dietrich N,Kornfeld K.Angiotensin converting enzyme (ACE) inhibitor extends Caenorhabditis elegans Life Span[J].Plos Genetics,2016,12(2):1-28.
[9] Bravo F V ,Da Silva J ,Chan R B ,et al.Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model[J].Scientific Reports,2018,8(1):3540-3552.
[10]Kim H,Perentis R J,Caldwell G A,et al.Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C.elegans Parkinson's models[J].Cell Death & Disease,2018,9(5):555 .
[11]Govindan S.Organoruthenium(II) complexes ameliorates oxidative stress and impedes the age associated deterioration in Caenorhabditis elegans through JNK-1/DAF-16 signalling[J].Scientific Reports,2018,8(1):7688-7702.
[12]赵晴,蒋湉湉.秀丽隐杆线虫研究综述[J].安徽农业科学,2010,38(19):10092-10093.
[13]张佳婵,王昌涛,刘瑶,等.沙棘粕醇提取物对秀丽隐杆线虫的抗衰老功效及其机制[J].食品科学,2017,38(23):141-148.
[14]Lee J H,Nam S H,Hwang S B,et al.Functional genomic approaches using the nematode Caenorhabditis elegans as a model system[J].J Biochem Mol Biol,2004,37(1):107-113.
[15]Brenner S.The genetics of Caenorhabditis elegans[J].Genetics,1974,77(1):71-94.
[16]Guarente L,Kenyon C.Genetic pathways that regulate ageing in model organisms[J].Nature,2000,408(6809):255-262.
[17]Hulme S E,Whitesides G M.Chemistry and the worm:Caenorhabditis elegans as a platform for integrating chemical and biological research[J].Cheminform,2011,50(21):4774-4807.
[18]Gruber J,Tang S Y,Halliwell B.Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans[J].Annals of the New York Academy of Sciences,2007,1100(1):530-542.
[19]Silverman G A,Luke C J,Bhatia S R,et al.Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans[J].Pediatric Research,2009,65(1):10-18.
[20]Consortium C E S.Genome sequence of the nematode C.elegans:a platform for investigating biology[J].Science,1998,282(5396):2012-2018.
[21]Honda Y,Tanaka M,Honda S.Trehalose extends longevity in the nematode Caenorhabditis elegans[J].Aging Cell,2010,9(4):558-569.
[22]Chen P,He D,Zhang Y,et al.Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate stress insult during aging[J].Food & Function,2016,7(11):4576-4588.
[23]Liu Y,Sun Y,Huang G.Preparation and antioxidant activities of important traditional plant polysaccharides[J].International Journal of Biological Macromolecules,2018,111:780-786.
[24]李海春.八种石斛多糖抗氧化、抗衰老活性的比较研究[D].华南农业大学,2016.
[25]Zhang Y,Lyu T,Li M,et al.Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans[J].Pharmacognosy Magazine,2015,11(43):449-454.
[26]Zhang Y,Mi D Y,Wang J,et al.Constituent and effects of polysaccharides isolated from Sophoramoorcroftiana seeds on lifespan,reproduction,stress resistance,and antimicrobial capacity in Caenorhabditis elegans[J].Chinese Journal of Natural Medicines,2018,16(4):252-260.
[27]Li Y,Guan S,Liu C,et al.Neuroprotective effects of Coptis chinensis Franch polysaccharide on amyloid-beta (Aβ)-induced toxicity in a transgenic Caenorhabditis elegans,model of Alzheimer's disease (AD)[J].International Journal of Biological Macromolecules,2018,113:991-995.
[28]Chuang M H,Chiou S H,Huang C H,et al.The lifespan-promoting effect of acetic acid and Reishi polysaccharide[J].Bioorganic & Medicinal Chemistry,2009,17(22):7831-7840.
[29]Zhang H,Pan N,Xiong S,et al.Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans[J].Biochemical Journal,2012,441(1):417-424.
[30]赵薪苑,陈婧,方建国,等.中药和天然药物中黄酮抗病毒活性及其机制研究进展[J].医药导报,2018,37(4):410-415.
[31]陈全利,胡莉,魏玮,等.杜仲总黄酮对大鼠神经源性肌萎缩的影响[J].遵义医学院学报,2016,39(6):563-567.
[32]汪巍,李明,艾纯芝,等.天然黄酮类化合物抑制CYP3A4的构效关系研究(英文)[J].遵义医学院学报,2017,40(1):6-16.
[33]凌伟,张伟,许凤清,等.利用秀丽隐杆线虫研究亳菊不同处理方法的生物活性[J].广州化工,2017,45(11):121-122.
[34]Grünz G,Haas K,Soukup S,et al.Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C.elegans[J].Mechanisms of Ageing & Development,2012,133(1):1-10.
[35]蔡外娇,张新民,黄建华,等.淫羊藿总黄酮延缓秀丽隐杆线虫衰老的实验研究[J].中国中西医结合杂志,2008,28(6):522-525.
[36]蔡外娇.淫羊藿总黄酮、淫羊藿苷、淫羊藿次苷Ⅱ延长健康寿限及其作用机制的研究[D].上海:复旦大学,2012.
[37]Dueňas M,Surcolaos F,Gonzálezmanzano S,et al.Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans[J].Pharmacological Research,2013,76(10):41-48.
[38]Pietsch K,Saul N,Menzel R,et al.Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1,daf-2,sek-1 and unc-43[J].Biogerontology,2009,10(5):565-578.
[39]周溦,林敬明,王素丽,等.半枝莲总黄酮对延缓秀丽隐杆线虫和人脐静脉内皮细胞衰老的影响[J].南方医科大学学报,2017,37(6):821-826.
[40]游庭活.桑椹多酚类化合物抗氧化及延缓衰老作用研究[D].广州:广东药学院,2015.
[41]邓冠军.黄连木叶酚类物质的提取鉴定、生物活性及与精油联产的研究[D].合肥:安徽大学,2014.
[42]Zhu G,Yin F,Wang L,et al.Microdevice for the investigation of high-glucose induced lifespan and the protective effect of polydatin in C.elegans[J].Chinese Journal of Chromatography,2016,34(2):140-145.
[43]Wen H,Gao X,Qin J.Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip[J].Science Foundation in China,2015,6(1):35-43.
[44]王婷婷,张玉瑶,王吉锡,等.白藜芦醇对秀丽隐杆线虫寿命的影响及其初步机制研究[J].神经药理学报,2015,5(5):1-6.
[45]Desjardins D,Cacho-Valadez B,Liu J,et al.Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans[J].Aging Cell,2017,16(1):104-112.
[46]Zheng S,Liao S,Zou Y,et al.Mulberry leaf polyphenols delay aging and regulate fat metabolism via the germline signaling pathway in Caenorhabditis elegans[J].AGE,2014,36(6):9719.
[47]唐进法,张帆,李宇辉,等.何首乌乙酸乙酯提取物对秀丽线虫的抗衰老作用研究[J].中国药房,2017,28(4):493-496.
[48]薛晓利,张建琴,马雯,等.基于～1H-NMR代谢组学的黄芪甲苷对秀丽隐杆线虫寿命的延长作用研究[J].中草药,2018,49(10):2274-2281.
[49]王丽萍,崔雅欣,徐佳,等.余甘子对秀丽隐杆线虫的抗衰老作用[J].吉林大学学报:理学版,2018,56(3):738-742.
[50]Feng S,Cheng H,Zhou X,et al.Thermal stress resistance and aging effects of Panax notoginseng,polysaccharides on Caenorhabditis elegans[J].International Journal of Biological Macromolecules,2015,81:188-194.
[51]Su S,Wink M.Natural lignans from Arctium lappa,as antiaging agents in Caenorhabditis elegans[J].Phytochemistry,2015,117:340-350.
[52]Lashmanova E,Zemskaya N,Proshkina E,et al.The evaluation of geroprotective effects of selected flavonoids in drosophila melanogaster and Caenorhabditis elegans[J].Frontiers in Pharmacology,2017,8:884.
[53]Wang X,Zhang J,Lu L,et al.The longevity effect of echinacoside in Caenorhabditis elegans mediated through daf-16[J].Bioscience Biotechnology & Biochemistry,2015,79(10):1676-1683.
[54]Pietsch K,Saul N,Chakrabarti S,et al.Hormetins,antioxidants and prooxidants:defining quercetin-,caffeic acid- and rosmarinic acid-mediated life extension in C.elegans[J].Biogerontology,2011,12(4):329-347.