摩梭人身体铁状态与血糖升高的相关性
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摘要
目的探讨中国云南摩梭人群生理性铁储备,贫血与血糖升高的相关性。方法收集云南省宁蒗县187名摩梭人血样,检测其糖化血红蛋白(HbA1c)、转铁蛋白受体(TfR)与血红蛋白水平(Hb)。逻辑回归分析摩梭人数据和中国全国性数据(CHNS)中铁状态与血糖升高的关系。结果与控制组相比,摩梭人缺铁而不贫血,即缺铁性红细胞生成(IDE)对应着血糖升高风险的上升(OR=2.70),这一结果与针对全国性数据的分析结果一致。结论相比健康人群,缺铁性贫血与非缺铁性贫血的摩梭人,缺铁而不存在贫血症状的摩梭人面临着血糖升高的风险。摩梭人身体铁水平对其2型糖尿病的风险评估与预防具有参考意义。
Objective To study the relationship between physiological iron reserve, anemia and elevated blood glucose in Mosuo population in Yunnan, China. Methods Blood samples were collected from 187 Mosuo people in Ninglang County, Yunnan Province, and their glycated hemoglobin(HbA1 c), transferrin receptor(TfR) and hemoglobin levels(Hb) were measured. Logistic Regression analysed the relationship between iron status and elevated blood glucose in Mosuo data and Chinese national data(CHNS). Results Compared with the control group, Mosuo people were deficient in iron without anemia, ie iron deficiency erythropoiesis(IDE) corresponds to an increase in the risk of elevated blood glucose(OR=2.70), which is consistent with national data for China. The results of the analysis are consistent. Conclusion Compared with healthy people, Mosuo people with iron deficiency anemia and non-iron deficiency anemia, Mosuo people who are deficient in iron without anemia are at risk of rising blood sugar. The body iron level of Mosuo people has reference significance for the risk and control of type 2 diabetes.
Objective To study the relationship between physiological iron reserve, anemia and elevated blood glucose in Mosuo population in Yunnan, China. Methods Blood samples were collected from 187 Mosuo people in Ninglang County, Yunnan Province, and their glycated hemoglobin(HbA1 c), transferrin receptor(TfR) and hemoglobin levels(Hb) were measured. Logistic Regression analysed the relationship between iron status and elevated blood glucose in Mosuo data and Chinese national data(CHNS). Results Compared with the control group, Mosuo people were deficient in iron without anemia, ie iron deficiency erythropoiesis(IDE) corresponds to an increase in the risk of elevated blood glucose(OR=2.70), which is consistent with national data for China. The results of the analysis are consistent. Conclusion Compared with healthy people, Mosuo people with iron deficiency anemia and non-iron deficiency anemia, Mosuo people who are deficient in iron without anemia are at risk of rising blood sugar. The body iron level of Mosuo people has reference significance for the risk and control of type 2 diabetes.
引文
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[2] Dandona P,Hussain MA,Varghese Z,et al.Insulin resistance and iron overload[J].Ann Clin Biochem,1983,20 Pt 2(2):77.
[3] Fernándezreal JM,Lópezbermejo A,Ricart W.Cross-talk between iron metabolism and diabetes[J].Diabetes,2002,51(8):2348-2354.
[4] Jiang R,Manson JE,Meigs JB,et al.Body iron stores in relation to risk of type 2 diabetes in apparently healthy women[J].JAMA,2004,291(6):711-717.
[5] Salonen JT,Tuomainen TP,Nyyss?nen K,et al.Relation between iron stores and non-insulin dependent diabetes in men:case-control study[J].BMJ,1998,317(7160):727-727.
[6] Shi Z,Hu X,Yuan B,et al.Association between serum ferritin,hemoglobin,iron intake,and diabetes in adults in Jiangsu,China[J].Diabetes Care,2006,29(8):1878-1883.
[7] Lao TT,Tse KY,Chan LY,et al.HBsAg carrier status and the association between gestational diabetes with increased serum ferritin concentration in Chinese women[J].Diabetes Care,2003,26(11):3011-3016.
[8] Shellduncan B,Mcdade T.Use of combined measures from capillary blood to assess iron deficiency in rural Kenyan children[J].J Nutr,2004,134(2):384-387.
[9] Mattewal A,Aldasouqi S,Solomon D,et al.A1cNow InView:a new simple method for office-based glycohemoglobin measurement[J].J Diabetes Sci Technol,2007,1(6):879-884.
[10] Zitkus BS.American diabetes association standards of medical care in diabetes[J].Nurse Pract,2014,30(Suppl 1):S12-S54.
[11] Chinese Medical Association Diabetes Association.Guideline for prevention and treatment of type 2 diabetes in China (2010) [J].Chinese Journal of Diabetes,2012,20 (1):54-109.(in Chinese)中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[J].中国糖尿病杂志,2012,20(1):54-109.
[12] Chen J,Ji LN,Zhou XH,et al.Meta-analysis of glycosylated hemoglobin in Chinese population screening for diabetes mellitus [J].Chinese Diabetes Journal,2018,26(3):177-187.(in Chinese)陈静,纪立农,周翔海,等.糖化血红蛋白在中国人群筛查糖尿病患者的荟萃分析[J].中国糖尿病杂志,2018,26(3):177-187
[13] Wander K,Shell-Duncan BT.Evaluation of iron deficiency as a nutritional adaptation to infectious disease:an evolutionary medicine perspective.[J].Am J Hum Biol,2010,21(2):172-179.
[14] Fujita M,Wander K.A test of the optimal iron hypothesis among breastfeeding Ariaal mothers in northern Kenya[J].Am J Phys Anthropol,2017,164(3):1-12.
[15] Wang WJ,Zhang XH,Yu KL,et al.The relationship between the length,width and height of the wooden people [J].Acta Anatomica Sinica,2016,47 (6):829-832.(in Chinese)王文佳,张兴华,宇克莉,等.木雅人的手长宽、足长宽与身高的关系[J].解剖学报,2016,47(6):829-832.
[16] Wei Y,Zhang XH,Yu KL,et al.Chinese kino,wooden,ersu,eight,and space 5 ethnic groups of the body [J].Acta Anatomica Sinica,2017,48 (5):605-609.(in Chinese)魏榆,张兴华,宇克莉,等.中国基诺族、木雅人、尔苏人、八甲人与空格人5个族群的体型特征[J].解剖学报,2017,48(5):605-609.
[17] Wang Y.Prevalence of diabetes among men and women in China — NEJM[J].New Engl J Med,2010,362(25):1090-1101.
[18] Yan S,Li J,Li S,et al.The expanding burden of cardiometabolic risk in China:the China Health and Nutrition Survey[J].Obes Rev,2012,13(9):810-821.