儿科抗病毒药物应用现状研究
|
摘要
目的分析我院儿科抗病毒药物的临床使用情况,促进合理用药。方法调取我院儿科2018年4月1日-9月30日住院期间使用过抗病毒药物注射剂的患儿,共计12 937例,涉及5 127例患儿;随机抽取20例,共计260例病例进行抗病毒注射剂使用点评,进行合理性分析。结果在统计的人群中,幼儿期和婴儿期合计3 188人,占62.18%;抗病毒药使用西药以注射用单磷酸阿糖腺苷为主,占41.70%;中药以注射用炎琥宁为主,占24.51%,共计有74例病例存在使用2种及以上的抗病毒药物,占28.46%,且较多存在中西药联合抗病毒治疗情况。结论临床抗病毒药物注射剂的使用不合理情况较多,药师需加强处方点评,规范抗病毒药物的合理使用。
Objective To analyze the clinical use of antiviral drugs in children in our hospital and promote rational drug use. Methods From April 1, 2018 to September 30, 2018, a total of 12 937 cases involving 5 127 children who had used antiviral injections in the pediatric department of our hospital were enrolled. A total of 260 cases were randomly selected from 13 branches. The prescriptions were analyzed and the characteristics of the drug were summarized. Results Among the statistic population, there were 3 188 infants, accounting for 62.18%; western medicine was mainly used with adenosine monophosphate for injection, accounting for 41.70%; Chinese medicine was mainly used with Yanhuning for injection, accounting for 24.51%. A total of 74 cases used two or more antiviral drugs, accounting for 28.46%, and more cases were treated with combination of Chinese and Western medicine. Conclusion There are many unreasonable use of antiviral injections in clinic. Clinical pharmacists need to strengthen prescription reviews to standardize the rational use of antiviral drugs in clinic.
Objective To analyze the clinical use of antiviral drugs in children in our hospital and promote rational drug use. Methods From April 1, 2018 to September 30, 2018, a total of 12 937 cases involving 5 127 children who had used antiviral injections in the pediatric department of our hospital were enrolled. A total of 260 cases were randomly selected from 13 branches. The prescriptions were analyzed and the characteristics of the drug were summarized. Results Among the statistic population, there were 3 188 infants, accounting for 62.18%; western medicine was mainly used with adenosine monophosphate for injection, accounting for 41.70%; Chinese medicine was mainly used with Yanhuning for injection, accounting for 24.51%. A total of 74 cases used two or more antiviral drugs, accounting for 28.46%, and more cases were treated with combination of Chinese and Western medicine. Conclusion There are many unreasonable use of antiviral injections in clinic. Clinical pharmacists need to strengthen prescription reviews to standardize the rational use of antiviral drugs in clinic.
引文
[1]刘自贵.抗病毒感染药物治疗进展[J].现代临床医学,2015(6):468-475.
[2]年国侠,吴冰冰.负面清单法干预注射用单磷酸阿糖腺苷不合理用药的效果分析[J].中国医院药学杂志, 2017,37(19):1983-1985.
[3]国家药品不良反应监测年度报告(2017年)[J].中国药物评价, 2018, 35(2):79-85.
[4]李艳媚.抗病毒药物在儿科临床中的应用分析[J].临床医学研究与实践, 2017, 2(16):108-109.
[5]王二琼.我院儿科门诊抗病毒药物联合应用现状及分析[J].临床医药文献电子杂志, 2017, 4(52):10250-10251, 10253.
[6]张国成,尚云晓.《重组人干扰素-α1b在儿科的临床应用专家共识》解读[J].中华实用儿科临床杂志, 2015,30(16):1220-1222.
[7]中华医学会儿科学分会免疫学组,《中华儿科杂志》编辑委员会.原发性免疫缺陷病抗感染治疗与预防专家共识[J].中华儿科杂志, 2017, 55(4):248-255.
[8]中华医学会儿科学分会感染学组,全国儿童EB病毒感染协作组.儿童主要非肿瘤性EB病毒感染相关疾病的诊断和治疗原则建议[J].中华儿科杂志, 2016, 54(8):563-568.
[9]中华医学会儿科学分会感染学组.儿童巨细胞病毒性疾病诊断和防治的建议[J].中华儿科杂志, 2012, 50(4):290-292.
[10]叶丽珍,杨源,赵艳,等.重组人干扰素α1b治疗手足口病[J].长春中医药大学学报, 2017, 33(2):288-289.
[11]支文煜,张桂芬,唐慧.我院104份儿科住院病历超说明书用药调查分析[J].儿科药学杂志, 2017, 23(12):42-46.
[12]张帆.利巴韦林与热毒宁治疗小儿急性上呼吸道感染[J].吉林中医药, 2017, 37(7):670-673.
[13]常莉,刘芳,石华,等.儿童EB病毒感染的临床特征及实验室检查分析[J].中国妇幼保健, 2019, 34(3):553-555.
[14]康旭丽,崔菲菲.儿童EB病毒感染肝功能异常的细胞免疫因素研究[J].中国医药导刊, 2018, 20(12):722-725.
[15]冯文雅,陈天明,胡冰,等.儿童单纯疱疹病毒性脑炎的临床特征、预后及遗传易感性[J].中华儿科杂志, 2015,53(9):701-706.
[16]李梦莹,徐凤艳,黄继汉,等.病毒动力学模型及评价[J].中国临床药理学与治疗学, 2016, 21(6):653-660.
[17]谷九莲,刘守胜,李昌飞,等.高灵敏度血清病毒学指标检测在低病毒载量乙型肝炎人群中的应用价值[J].临床肝胆病杂志, 2018, 34(6):1302-1307.
[2]年国侠,吴冰冰.负面清单法干预注射用单磷酸阿糖腺苷不合理用药的效果分析[J].中国医院药学杂志, 2017,37(19):1983-1985.
[3]国家药品不良反应监测年度报告(2017年)[J].中国药物评价, 2018, 35(2):79-85.
[4]李艳媚.抗病毒药物在儿科临床中的应用分析[J].临床医学研究与实践, 2017, 2(16):108-109.
[5]王二琼.我院儿科门诊抗病毒药物联合应用现状及分析[J].临床医药文献电子杂志, 2017, 4(52):10250-10251, 10253.
[6]张国成,尚云晓.《重组人干扰素-α1b在儿科的临床应用专家共识》解读[J].中华实用儿科临床杂志, 2015,30(16):1220-1222.
[7]中华医学会儿科学分会免疫学组,《中华儿科杂志》编辑委员会.原发性免疫缺陷病抗感染治疗与预防专家共识[J].中华儿科杂志, 2017, 55(4):248-255.
[8]中华医学会儿科学分会感染学组,全国儿童EB病毒感染协作组.儿童主要非肿瘤性EB病毒感染相关疾病的诊断和治疗原则建议[J].中华儿科杂志, 2016, 54(8):563-568.
[9]中华医学会儿科学分会感染学组.儿童巨细胞病毒性疾病诊断和防治的建议[J].中华儿科杂志, 2012, 50(4):290-292.
[10]叶丽珍,杨源,赵艳,等.重组人干扰素α1b治疗手足口病[J].长春中医药大学学报, 2017, 33(2):288-289.
[11]支文煜,张桂芬,唐慧.我院104份儿科住院病历超说明书用药调查分析[J].儿科药学杂志, 2017, 23(12):42-46.
[12]张帆.利巴韦林与热毒宁治疗小儿急性上呼吸道感染[J].吉林中医药, 2017, 37(7):670-673.
[13]常莉,刘芳,石华,等.儿童EB病毒感染的临床特征及实验室检查分析[J].中国妇幼保健, 2019, 34(3):553-555.
[14]康旭丽,崔菲菲.儿童EB病毒感染肝功能异常的细胞免疫因素研究[J].中国医药导刊, 2018, 20(12):722-725.
[15]冯文雅,陈天明,胡冰,等.儿童单纯疱疹病毒性脑炎的临床特征、预后及遗传易感性[J].中华儿科杂志, 2015,53(9):701-706.
[16]李梦莹,徐凤艳,黄继汉,等.病毒动力学模型及评价[J].中国临床药理学与治疗学, 2016, 21(6):653-660.
[17]谷九莲,刘守胜,李昌飞,等.高灵敏度血清病毒学指标检测在低病毒载量乙型肝炎人群中的应用价值[J].临床肝胆病杂志, 2018, 34(6):1302-1307.