牛磺酸对胎儿宫内生长受限的预防作用
|
摘要
动物胎儿宫内生长受限(IUGR)发病率约为10%～20%,已发现IUGR严重影响子代个体生长发育,出生后会引起多种疾病,是国内外家畜繁殖中的主要研究热点之一。但对于IUGR,临床并没有高效满意的治疗方法,主要以产前预防为主。牛磺酸是一种非蛋白质的游离氨基酸,越来越多的研究表明牛磺酸对胎儿及新生儿发育以及中枢神经系统具有重要作用,孕期补充牛磺酸在预防IUGR患儿脑神经发育方面具有一定成效。论文对IUGR的发生和牛磺酸在各个系统预防IUGR作用与应用进行综述,为进一步探讨牛磺酸预防IUGR的发生提供参考。
The limited incidence of intrauterine growth(IUGR) in animals is 10%-20%,which seriously affects the growth and development of the individual.It has been found that it can cause many kinds of diseases.It is one of the main research hotspots in domestic and foreign animal breeding.For IUGR,there is no efficient and satisfactory treatment method,mainly prenatal prevention.Taurine is a non-protein free amino acid. More and more literatures indicate that taurine plays an important role in the growth and development of fetus and neonates as well as the central nervous system.It has been confirmed that supplementation of taurine during pregnancy can prevent the development of fetal brain with IUGR,but there is little research on other systems.This paper reviewed the occurrence of IUGR and the role and application of taurine in the prevention of IUGR in various systems,providing a reference for further exploring the prevention of IUGR by taurine.
The limited incidence of intrauterine growth(IUGR) in animals is 10%-20%,which seriously affects the growth and development of the individual.It has been found that it can cause many kinds of diseases.It is one of the main research hotspots in domestic and foreign animal breeding.For IUGR,there is no efficient and satisfactory treatment method,mainly prenatal prevention.Taurine is a non-protein free amino acid. More and more literatures indicate that taurine plays an important role in the growth and development of fetus and neonates as well as the central nervous system.It has been confirmed that supplementation of taurine during pregnancy can prevent the development of fetal brain with IUGR,but there is little research on other systems.This paper reviewed the occurrence of IUGR and the role and application of taurine in the prevention of IUGR in various systems,providing a reference for further exploring the prevention of IUGR by taurine.
引文
[1] 刘薇,刘敬.宫内生长受限新生儿多器官损坏与临床管理[J].中国小儿急救医学,2016,23(5):289-294.
[2] Dessi A,Marincola F C,FanosV.Best pract res clin obstet gynaecol,metabolomics and the great obsterical syndromes[J].Gdm Pet and Iugr,2015,29(2):156-164.
[3] Sharma D,Shastri S,Farahbakhsh N,et al.Intrauterine growth restriction[J].J Matern Fetal Neonatal Med,2016,29(24):3977-3987.
[4] Wu G,Bazer F W,Cudd T A,el al.Maternal nutrition and fetal development[J].J Nutr,2004,134(9):2169-2172.
[5] Ruiz-González M D,Caňete M D,Gómez-Chaparro J L,et al.Morbility,clinical data and proteomic analysis of IUGR and AGA newborns at different gestational ages[J].Data Brief,2016,9:438-447.
[6] 陈远华.母体孕期维生素D状况与胎儿宫内生长受限的关联研究[D].安徽合肥:安徽医科大学,2014.
[7] 辜楠,陈小慧,郭锡熔,等.线粒体在宫内生长受限胎盘中的变化[J].临床儿科杂志,2013(12):1169-1172.
[8] Reindl K M,Kittilson J D,Bergan H E,et al.Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK,PI3K-AKT,and JAK-STAT [J].Am J Physiol Regul Integr Comp Physiol,2011,301(1):236-243.
[9] Martín-Estal I,de la Garza R G,Castilla-Cortázar I.Intrauterine growth retardation (IUGR) as a novel condition of insulin-like growth factor-1 (IGF-1) deficiency [J].Rev Physiol Biochem Pharmacol,2016,170:1-35.
[10] Huant T J,Khan A A,Pati S,et al.IGF-1 enhances cell proliferation and survival duringearly differentiation of mesenchymal stem cells to neural progenitor-like cells[J].BMC Neurosci,2014,15:91.
[11] Schaffer S,Kim H W.Effects and mechanisms of taurine as a therapeutic agent[J].Biomol Ther(Seoul),2018,26(3):225-241.
[12] Guellec I,Lapillonne A,Renolleau S,et al.Neurologic outcomes at School age in very preterm infants bom with severe or mild growth restriction[J].Pediatrics,2011,127(4):883-891.
[13] 刘颖.宫内生长受限抑制胎儿脑功能发育及孕鼠补充牛磺酸促进生长受限胎鼠神经元增殖研究[D].安徽合肥:安徽医科大学,2014.
[14] 王晓凤,滕惠云,刘敬,等.孕鼠补充牛磺酸减少胎儿生长受限鼠脑细胞凋亡[J].中国围产医学杂志,2013,16(3):165-169.
[15] Liu F,Liu Y,Liu J,et al.Antenatal taurine improves intrauterine growth-restricted fetal rat brain development which is associated with increasing the activity of PKA-CaMKII/c-fos signal pathway[J].Neuropediatrics,2015,46(5):299-306.
[16] 刘晓梅,顾卉,苗佳宁,等.宫内生长受限子鼠肝脏脂肪代谢关键酶表达的研究[J].中国现代医学杂志,2013,23(20):7-11.
[17] Liu Y,Ma C,Li H.Effects of intrauterine growth restriction during late pregnancy on the cell apoptosis and related gene expression in ovine fetal liver[J] .Theriogenology,2017,90:204-209.
[18] 刘晓梅,卢岩,潘莉莉,等.宫内生长受限大鼠肝脏异生酶的表达增加与胰岛素抵抗[J].中国当代儿科杂志,2008,10(2):216-220.
[19] Dong L,Zhong X,Ahmad H,et al.Intrauterine growth restriction impairs small intestinal mucosal immunity in neonatal piglets [J].J Histochem Cytochem,2014,62(7):510-518.
[20] 肖敏.牛磺酸对雏鸡小肠炎症的预防作用[D].浙江杭州:浙江大学,2016.
[21] 聂娅,老兆航,许裕珠,等.时间-空间相关成像技术评估宫内生长受限胎儿心功能的研究[J].中国中西医结合影像学杂志,2018,16(4):371-373.
[22] Schaffer S W,Shimada-Takaura K,Jong C J,et al.Impaired energy metabolism of the taurine deficient heart [J].Amino Acids,2016,48(2):549-558.
[23] 王晓凤,曾安军,刘敬,等.胎儿宫内生长受限发生率调查及其对胎儿新生儿健康危害研究[J].中国儿童保健杂志,2013,10(1):1020-1023.
[24] 马超,彭乐,王元祥,等.牛磺酸对婴幼儿体外循环肺损伤的保护作用[J].临床和实验医学杂志,2010(16):1213-1215.
[25] 王妍平,王冠,崔洪艳,等.胎儿生长受限对其肾脏发育的影响[J].国际妇产科学杂志,2016(1):29-31.
[26] 王妍平.宫内生长受限胎儿的肾脏发育及其相关机制探讨[D].天津:天津大学,2011.
[27] 邹成丽.宫内生长受限胎儿糖和脂质代谢紊乱机制的临床及动物实验研究[D].四川泸州:西南医科大学2017.
[28] Tang C,Marchand K,Lam L,et al.Maternal taurine supplementation in rats partially prevents the adverse effects of early-life protein deprivation on β-cell function and insulin sensitivity[J].Reproduction,2013,145(6):609-620.
[2] Dessi A,Marincola F C,FanosV.Best pract res clin obstet gynaecol,metabolomics and the great obsterical syndromes[J].Gdm Pet and Iugr,2015,29(2):156-164.
[3] Sharma D,Shastri S,Farahbakhsh N,et al.Intrauterine growth restriction[J].J Matern Fetal Neonatal Med,2016,29(24):3977-3987.
[4] Wu G,Bazer F W,Cudd T A,el al.Maternal nutrition and fetal development[J].J Nutr,2004,134(9):2169-2172.
[5] Ruiz-González M D,Caňete M D,Gómez-Chaparro J L,et al.Morbility,clinical data and proteomic analysis of IUGR and AGA newborns at different gestational ages[J].Data Brief,2016,9:438-447.
[6] 陈远华.母体孕期维生素D状况与胎儿宫内生长受限的关联研究[D].安徽合肥:安徽医科大学,2014.
[7] 辜楠,陈小慧,郭锡熔,等.线粒体在宫内生长受限胎盘中的变化[J].临床儿科杂志,2013(12):1169-1172.
[8] Reindl K M,Kittilson J D,Bergan H E,et al.Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK,PI3K-AKT,and JAK-STAT [J].Am J Physiol Regul Integr Comp Physiol,2011,301(1):236-243.
[9] Martín-Estal I,de la Garza R G,Castilla-Cortázar I.Intrauterine growth retardation (IUGR) as a novel condition of insulin-like growth factor-1 (IGF-1) deficiency [J].Rev Physiol Biochem Pharmacol,2016,170:1-35.
[10] Huant T J,Khan A A,Pati S,et al.IGF-1 enhances cell proliferation and survival duringearly differentiation of mesenchymal stem cells to neural progenitor-like cells[J].BMC Neurosci,2014,15:91.
[11] Schaffer S,Kim H W.Effects and mechanisms of taurine as a therapeutic agent[J].Biomol Ther(Seoul),2018,26(3):225-241.
[12] Guellec I,Lapillonne A,Renolleau S,et al.Neurologic outcomes at School age in very preterm infants bom with severe or mild growth restriction[J].Pediatrics,2011,127(4):883-891.
[13] 刘颖.宫内生长受限抑制胎儿脑功能发育及孕鼠补充牛磺酸促进生长受限胎鼠神经元增殖研究[D].安徽合肥:安徽医科大学,2014.
[14] 王晓凤,滕惠云,刘敬,等.孕鼠补充牛磺酸减少胎儿生长受限鼠脑细胞凋亡[J].中国围产医学杂志,2013,16(3):165-169.
[15] Liu F,Liu Y,Liu J,et al.Antenatal taurine improves intrauterine growth-restricted fetal rat brain development which is associated with increasing the activity of PKA-CaMKII/c-fos signal pathway[J].Neuropediatrics,2015,46(5):299-306.
[16] 刘晓梅,顾卉,苗佳宁,等.宫内生长受限子鼠肝脏脂肪代谢关键酶表达的研究[J].中国现代医学杂志,2013,23(20):7-11.
[17] Liu Y,Ma C,Li H.Effects of intrauterine growth restriction during late pregnancy on the cell apoptosis and related gene expression in ovine fetal liver[J] .Theriogenology,2017,90:204-209.
[18] 刘晓梅,卢岩,潘莉莉,等.宫内生长受限大鼠肝脏异生酶的表达增加与胰岛素抵抗[J].中国当代儿科杂志,2008,10(2):216-220.
[19] Dong L,Zhong X,Ahmad H,et al.Intrauterine growth restriction impairs small intestinal mucosal immunity in neonatal piglets [J].J Histochem Cytochem,2014,62(7):510-518.
[20] 肖敏.牛磺酸对雏鸡小肠炎症的预防作用[D].浙江杭州:浙江大学,2016.
[21] 聂娅,老兆航,许裕珠,等.时间-空间相关成像技术评估宫内生长受限胎儿心功能的研究[J].中国中西医结合影像学杂志,2018,16(4):371-373.
[22] Schaffer S W,Shimada-Takaura K,Jong C J,et al.Impaired energy metabolism of the taurine deficient heart [J].Amino Acids,2016,48(2):549-558.
[23] 王晓凤,曾安军,刘敬,等.胎儿宫内生长受限发生率调查及其对胎儿新生儿健康危害研究[J].中国儿童保健杂志,2013,10(1):1020-1023.
[24] 马超,彭乐,王元祥,等.牛磺酸对婴幼儿体外循环肺损伤的保护作用[J].临床和实验医学杂志,2010(16):1213-1215.
[25] 王妍平,王冠,崔洪艳,等.胎儿生长受限对其肾脏发育的影响[J].国际妇产科学杂志,2016(1):29-31.
[26] 王妍平.宫内生长受限胎儿的肾脏发育及其相关机制探讨[D].天津:天津大学,2011.
[27] 邹成丽.宫内生长受限胎儿糖和脂质代谢紊乱机制的临床及动物实验研究[D].四川泸州:西南医科大学2017.
[28] Tang C,Marchand K,Lam L,et al.Maternal taurine supplementation in rats partially prevents the adverse effects of early-life protein deprivation on β-cell function and insulin sensitivity[J].Reproduction,2013,145(6):609-620.